<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2021 Workiva-->
<!--r:6823d77b-6ed5-424a-96ca-e143e76107fa,g:321be9fe-0c5f-47c2-824e-70d746643530-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.xerispharma.com/role/DEIDocument" xlink:type="simple" xlink:href="xers-20201231.xsd#DEIDocument"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/DEIDocument" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:href="xers-20201231.xsd#xers_DocumentandEntityInformationAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_16cfbdd4-6106-4663-8d78-9be7c245ab87" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_CurrentFiscalYearEndDate_16cfbdd4-6106-4663-8d78-9be7c245ab87" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_0c893c7b-c93b-45ef-99a1-6e6e274b3b58" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityCurrentReportingStatus"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_EntityCurrentReportingStatus_0c893c7b-c93b-45ef-99a1-6e6e274b3b58" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityWellKnownSeasonedIssuer_196481ba-4013-4ca5-ac9f-432da7601068" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityWellKnownSeasonedIssuer"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_EntityWellKnownSeasonedIssuer_196481ba-4013-4ca5-ac9f-432da7601068" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_d448e3f4-4415-4f2e-9b85-eef888c6e662" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityFilerCategory"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_EntityFilerCategory_d448e3f4-4415-4f2e-9b85-eef888c6e662" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityVoluntaryFilers_088e1dd0-c90e-42ec-88bb-ebb3f1402eb9" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityVoluntaryFilers"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_EntityVoluntaryFilers_088e1dd0-c90e-42ec-88bb-ebb3f1402eb9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityExTransitionPeriod_59ae272d-6bc9-43f4-9771-8b32163fe75a" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityExTransitionPeriod"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_EntityExTransitionPeriod_59ae272d-6bc9-43f4-9771-8b32163fe75a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_2c06452b-c2c6-4a69-962b-d97f122c7355" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_DocumentPeriodEndDate_2c06452b-c2c6-4a69-962b-d97f122c7355" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_44bf4e15-301b-492d-9816-73ad388d6491" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_EntityFileNumber_44bf4e15-301b-492d-9816-73ad388d6491" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_32f981d5-10a4-457e-ab25-e7cb1f7a8ed1" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_EntityAddressAddressLine1_32f981d5-10a4-457e-ab25-e7cb1f7a8ed1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_2656774e-bc3f-4db1-838b-ef43547d9d4e" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_EntityAddressAddressLine2_2656774e-bc3f-4db1-838b-ef43547d9d4e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_30d7b15d-8c7f-4b94-a6f9-1cc9fd702eb6" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_EntityAddressCityOrTown_30d7b15d-8c7f-4b94-a6f9-1cc9fd702eb6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_529a1252-8ca5-4ca6-92e8-c0cb201d9eb3" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_EntityAddressStateOrProvince_529a1252-8ca5-4ca6-92e8-c0cb201d9eb3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_dcd9ff0d-26d6-4d5b-8fa4-2631484a9850" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_CityAreaCode_dcd9ff0d-26d6-4d5b-8fa4-2631484a9850" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_182a7fc2-dd8a-448d-bdb7-d1228403fe53" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_LocalPhoneNumber_182a7fc2-dd8a-448d-bdb7-d1228403fe53" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_dfc46c23-4c5e-4368-be5e-9cc0ab56bb0c" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentFiscalYearFocus"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_DocumentFiscalYearFocus_dfc46c23-4c5e-4368-be5e-9cc0ab56bb0c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_f98a1429-b4b8-40b2-97af-f4b2b73f5179" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_DocumentFiscalPeriodFocus_f98a1429-b4b8-40b2-97af-f4b2b73f5179" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_20e16779-68ea-4ba8-b49b-90fb16eed07e" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_AmendmentFlag_20e16779-68ea-4ba8-b49b-90fb16eed07e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_f977a01f-24e6-419c-93e5-2fe14c7b72d0" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_TradingSymbol_f977a01f-24e6-419c-93e5-2fe14c7b72d0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_338f4cc2-e27f-4e7b-9f18-caef42ba3d7d" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_Security12bTitle_338f4cc2-e27f-4e7b-9f18-caef42ba3d7d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_b35ab417-9ba5-4b5b-bb86-64e7ab9adcfd" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityInteractiveDataCurrent"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_EntityInteractiveDataCurrent_b35ab417-9ba5-4b5b-bb86-64e7ab9adcfd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_ab3f9ce1-9f5e-45ba-b182-e4b26749a6d6" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_ab3f9ce1-9f5e-45ba-b182-e4b26749a6d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityListingParValuePerShare_50f028b0-ddec-4fb0-acb4-0c51934fcc52" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityListingParValuePerShare"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_EntityListingParValuePerShare_50f028b0-ddec-4fb0-acb4-0c51934fcc52" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityPublicFloat_1241992d-9a54-4735-9b47-83f610030190" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityPublicFloat"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_EntityPublicFloat_1241992d-9a54-4735-9b47-83f610030190" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentAnnualReport_7d5aa1d2-af05-43e9-ab38-cf2e46381eaf" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentAnnualReport"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_DocumentAnnualReport_7d5aa1d2-af05-43e9-ab38-cf2e46381eaf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_0482e8e0-899f-481e-96dd-9291ce295570" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="25" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_EntityIncorporationStateCountryCode_0482e8e0-899f-481e-96dd-9291ce295570" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_cc8ed577-7c65-4013-95ef-94cf86b0932b" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="26" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_EntityTaxIdentificationNumber_cc8ed577-7c65-4013-95ef-94cf86b0932b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_bf319d97-a505-4c1d-b28a-6f04933a445a" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="27" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_EntityAddressPostalZipCode_bf319d97-a505-4c1d-b28a-6f04933a445a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_28288bd7-54e2-47ad-8705-07f565fca501" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="28" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_SecurityExchangeName_28288bd7-54e2-47ad-8705-07f565fca501" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_76ccba2a-8b0f-4711-920d-817cb1ad7db0" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_TradingSymbol"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_c7c0b74e-26f3-4ea9-a1ff-081fc5ccdc04" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_Security12bTitle"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityExTransitionPeriod_f902ccea-832c-424d-9922-a35f5748e45d" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityExTransitionPeriod"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_IcfrAuditorAttestationFlag_dce8f869-afaf-43a1-a211-902854062cdf" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_IcfrAuditorAttestationFlag"/>
    <link:presentationArc order="32" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_IcfrAuditorAttestationFlag_dce8f869-afaf-43a1-a211-902854062cdf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport_9a3935a5-bb82-49bc-89aa-802006c191b6" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentTransitionReport"/>
    <link:presentationArc order="33" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_DocumentTransitionReport_9a3935a5-bb82-49bc-89aa-802006c191b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_c61cf408-163b-4c6f-aa35-0add1cf9adc0" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_830e113a-f7f4-429e-a575-73a1db7809a9" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityCurrentReportingStatus"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityWellKnownSeasonedIssuer_083bce81-f5d7-4c11-94f2-113cc18524a8" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityWellKnownSeasonedIssuer"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_fe86da15-36d5-4430-96fb-0abcf9194259" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityFilerCategory"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityVoluntaryFilers_ee0efbc3-a2dc-49d8-8539-39895c8af4c3" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityVoluntaryFilers"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_1e6fe264-728f-46af-b125-71e07bc53bc7" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentPeriodEndDate"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_13776cfd-2988-466c-b76b-ba897227599c" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityFileNumber"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_55545ee2-df58-4d3a-aadc-bd149247bc35" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressAddressLine1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_920a823b-2acf-4eec-9e72-5a47373f2d07" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressAddressLine2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_ebb8244b-7d06-48ae-8e0d-9c28a974be90" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressCityOrTown"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_446d0381-0336-4398-99ec-4bfa16e28d32" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressStateOrProvince"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_d0760c87-7f37-49dd-a297-0e0c36365473" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_CityAreaCode"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_6971a58d-f7db-40a1-84e0-f6193e198cf9" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_LocalPhoneNumber"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_7a3de980-4676-421c-a425-fb484e7b8eaa" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentFiscalYearFocus"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_57ff6023-1492-4986-b73e-f6d2c91cefbb" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_2e9e04bc-5f68-4d65-8e77-00438fcb481d" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_AmendmentFlag"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_f23ec459-840f-42ff-a8e1-5cbd83809ff7" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityInteractiveDataCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_fe7dfbd4-2b58-4709-9964-45024c26f18a" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntitySmallBusiness"/>
    <link:presentationArc order="51" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_EntitySmallBusiness_fe7dfbd4-2b58-4709-9964-45024c26f18a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_ced4c7f9-c67f-4991-a856-e26b15ca8a5d" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="52" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_EntityEmergingGrowthCompany_ced4c7f9-c67f-4991-a856-e26b15ca8a5d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_e48be7d0-546d-4177-8e4c-9b616923859e" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityListingParValuePerShare_1096da2b-7140-4b1b-b835-231b7ad43ef2" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityListingParValuePerShare"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityPublicFloat_c66b2c74-e6d2-429f-b868-4d90a731b449" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityPublicFloat"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_6b73bfff-9457-47dd-b185-7c4a6139355a" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentType"/>
    <link:presentationArc order="56" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_DocumentType_6b73bfff-9457-47dd-b185-7c4a6139355a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_0bdfb94a-2ef0-45f0-a5f4-a4a725428e2e" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="57" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_EntityCentralIndexKey_0bdfb94a-2ef0-45f0-a5f4-a4a725428e2e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_d1b4038f-b705-4a2f-bea4-410ac44bbc84" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="58" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_EntityRegistrantName_d1b4038f-b705-4a2f-bea4-410ac44bbc84" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_1613e583-562c-4184-978b-9eddbd4cddcd" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityShellCompany"/>
    <link:presentationArc order="59" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_DocumentandEntityInformationAbstract_b2875f02-a3e4-4fa5-80f3-483da99ffde5" xlink:to="loc_dei_EntityShellCompany_1613e583-562c-4184-978b-9eddbd4cddcd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/ConsolidatedBalanceSheets" xlink:type="simple" xlink:href="xers-20201231.xsd#ConsolidatedBalanceSheets"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_BalanceSheetsAbstract_104d9530-c325-4130-bc2b-63747f8cf9b6" xlink:href="xers-20201231.xsd#xers_BalanceSheetsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract_b24dcb0f-1ed7-4de9-8298-9b71893b06e7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_BalanceSheetsAbstract_104d9530-c325-4130-bc2b-63747f8cf9b6" xlink:to="loc_us-gaap_AssetsAbstract_b24dcb0f-1ed7-4de9-8298-9b71893b06e7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrentAbstract_3af72eff-0ca4-443e-997a-f97e7cb6d3f5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsCurrentAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_b24dcb0f-1ed7-4de9-8298-9b71893b06e7" xlink:to="loc_us-gaap_AssetsCurrentAbstract_3af72eff-0ca4-443e-997a-f97e7cb6d3f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_010f7e30-294f-4d78-8ba2-bfdcec1ec644" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_3af72eff-0ca4-443e-997a-f97e7cb6d3f5" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_010f7e30-294f-4d78-8ba2-bfdcec1ec644" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_40e29d55-f40c-42fe-8e3a-89672f8e5342" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShortTermInvestments"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_3af72eff-0ca4-443e-997a-f97e7cb6d3f5" xlink:to="loc_us-gaap_ShortTermInvestments_40e29d55-f40c-42fe-8e3a-89672f8e5342" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_90a434e7-d504-419d-bd28-75471a826574" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_3af72eff-0ca4-443e-997a-f97e7cb6d3f5" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_90a434e7-d504-419d-bd28-75471a826574" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_1c5b4336-8a27-4974-8183-f182866b4a7c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryNet"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_3af72eff-0ca4-443e-997a-f97e7cb6d3f5" xlink:to="loc_us-gaap_InventoryNet_1c5b4336-8a27-4974-8183-f182866b4a7c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseCurrent_81d80c02-0f01-40f7-a4a4-3aad7db552d5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PrepaidExpenseCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_3af72eff-0ca4-443e-997a-f97e7cb6d3f5" xlink:to="loc_us-gaap_PrepaidExpenseCurrent_81d80c02-0f01-40f7-a4a4-3aad7db552d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_9ea4a21b-6349-4b0e-86b6-ecb627300569" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_3af72eff-0ca4-443e-997a-f97e7cb6d3f5" xlink:to="loc_us-gaap_AssetsCurrent_9ea4a21b-6349-4b0e-86b6-ecb627300569" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermInvestments_4ed9653a-8486-4e6e-8fba-3f11e7275d0c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermInvestments"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_b24dcb0f-1ed7-4de9-8298-9b71893b06e7" xlink:to="loc_us-gaap_LongTermInvestments_4ed9653a-8486-4e6e-8fba-3f11e7275d0c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_b464f3a8-0f89-4834-9627-466a65bede93" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_b24dcb0f-1ed7-4de9-8298-9b71893b06e7" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_b464f3a8-0f89-4834-9627-466a65bede93" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_fc1a887d-7bca-4a07-836c-cddafb635a73" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_b24dcb0f-1ed7-4de9-8298-9b71893b06e7" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_fc1a887d-7bca-4a07-836c-cddafb635a73" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_e38c87e2-a48f-4186-889b-d8daea2abeee" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Assets"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_b24dcb0f-1ed7-4de9-8298-9b71893b06e7" xlink:to="loc_us-gaap_Assets_e38c87e2-a48f-4186-889b-d8daea2abeee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_5fc3ec21-5a8f-4951-bf4f-5fc529f216fd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_BalanceSheetsAbstract_104d9530-c325-4130-bc2b-63747f8cf9b6" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_5fc3ec21-5a8f-4951-bf4f-5fc529f216fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_c81b0b11-feec-4837-91c5-3392b85b960d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_5fc3ec21-5a8f-4951-bf4f-5fc529f216fd" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_c81b0b11-feec-4837-91c5-3392b85b960d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_dc51ac86-903a-43de-8329-7b33dc450ce9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_c81b0b11-feec-4837-91c5-3392b85b960d" xlink:to="loc_us-gaap_AccountsPayableCurrent_dc51ac86-903a-43de-8329-7b33dc450ce9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_aebe003a-0628-4b2d-8b64-5e67bcf03948" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_c81b0b11-feec-4837-91c5-3392b85b960d" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_aebe003a-0628-4b2d-8b64-5e67bcf03948" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_AccrualForRebatesAndTradeDiscounts_73541b2e-9221-464b-914f-aeb8c047bd98" xlink:href="xers-20201231.xsd#xers_AccrualForRebatesAndTradeDiscounts"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_c81b0b11-feec-4837-91c5-3392b85b960d" xlink:to="loc_xers_AccrualForRebatesAndTradeDiscounts_73541b2e-9221-464b-914f-aeb8c047bd98" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Accruedreturnsreserve_4dabe996-16ed-4fbd-8ee0-47ffa16c6599" xlink:href="xers-20201231.xsd#xers_Accruedreturnsreserve"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_c81b0b11-feec-4837-91c5-3392b85b960d" xlink:to="loc_xers_Accruedreturnsreserve_4dabe996-16ed-4fbd-8ee0-47ffa16c6599" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_4987d1ef-a100-497e-abf8-1f0e8851bf87" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_c81b0b11-feec-4837-91c5-3392b85b960d" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_4987d1ef-a100-497e-abf8-1f0e8851bf87" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_35f15e2a-b161-4d14-8d68-ad55fb15b59d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_c81b0b11-feec-4837-91c5-3392b85b960d" xlink:to="loc_us-gaap_LiabilitiesCurrent_35f15e2a-b161-4d14-8d68-ad55fb15b59d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_5755839b-9e61-41ac-8a04-0c61d4ba41c9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_BalanceSheetsAbstract_104d9530-c325-4130-bc2b-63747f8cf9b6" xlink:to="loc_us-gaap_LongTermDebt_5755839b-9e61-41ac-8a04-0c61d4ba41c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredRentCreditNoncurrent_6b060f52-b7ee-4603-8947-666dcabe110e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredRentCreditNoncurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_BalanceSheetsAbstract_104d9530-c325-4130-bc2b-63747f8cf9b6" xlink:to="loc_us-gaap_DeferredRentCreditNoncurrent_6b060f52-b7ee-4603-8947-666dcabe110e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent_6c51412c-c70d-46cd-aa0e-82bdd548805b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_BalanceSheetsAbstract_104d9530-c325-4130-bc2b-63747f8cf9b6" xlink:to="loc_us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent_6c51412c-c70d-46cd-aa0e-82bdd548805b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_8db711e2-cf4d-410e-890e-d7fd4d384915" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_BalanceSheetsAbstract_104d9530-c325-4130-bc2b-63747f8cf9b6" xlink:to="loc_us-gaap_Liabilities_8db711e2-cf4d-410e-890e-d7fd4d384915" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_6488f3b4-f6f9-407d-b7ec-3b0c1ff8701d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_BalanceSheetsAbstract_104d9530-c325-4130-bc2b-63747f8cf9b6" xlink:to="loc_us-gaap_CommitmentsAndContingencies_6488f3b4-f6f9-407d-b7ec-3b0c1ff8701d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_StockholdersEquityDeficitAbstract_02190f7e-cd7a-4db3-958c-239682104a03" xlink:href="xers-20201231.xsd#xers_StockholdersEquityDeficitAbstract"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_BalanceSheetsAbstract_104d9530-c325-4130-bc2b-63747f8cf9b6" xlink:to="loc_xers_StockholdersEquityDeficitAbstract_02190f7e-cd7a-4db3-958c-239682104a03" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_057af5eb-ddc3-40c6-81e7-38e0a237791b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_StockholdersEquityDeficitAbstract_02190f7e-cd7a-4db3-958c-239682104a03" xlink:to="loc_us-gaap_PreferredStockValue_057af5eb-ddc3-40c6-81e7-38e0a237791b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_c55c4656-7e8c-48d6-ae20-90e836b402c9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_StockholdersEquityDeficitAbstract_02190f7e-cd7a-4db3-958c-239682104a03" xlink:to="loc_us-gaap_CommonStockValue_c55c4656-7e8c-48d6-ae20-90e836b402c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_735b9d7e-8c6c-4db9-a5ad-c6282d407e10" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_StockholdersEquityDeficitAbstract_02190f7e-cd7a-4db3-958c-239682104a03" xlink:to="loc_us-gaap_AdditionalPaidInCapital_735b9d7e-8c6c-4db9-a5ad-c6282d407e10" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_d283a908-d1f3-4f00-9ff8-95a71377ab68" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_StockholdersEquityDeficitAbstract_02190f7e-cd7a-4db3-958c-239682104a03" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_d283a908-d1f3-4f00-9ff8-95a71377ab68" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_f7db0b1a-efd6-439b-88ad-c4b4f34e8a9e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_StockholdersEquityDeficitAbstract_02190f7e-cd7a-4db3-958c-239682104a03" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_f7db0b1a-efd6-439b-88ad-c4b4f34e8a9e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_46dca7bb-3c6c-4682-8ff2-58e90981485a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_StockholdersEquityDeficitAbstract_02190f7e-cd7a-4db3-958c-239682104a03" xlink:to="loc_us-gaap_StockholdersEquity_46dca7bb-3c6c-4682-8ff2-58e90981485a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_8596ea6d-556d-42f3-acf9-5cd2be492b95" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_BalanceSheetsAbstract_104d9530-c325-4130-bc2b-63747f8cf9b6" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_8596ea6d-556d-42f3-acf9-5cd2be492b95" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="xers-20201231.xsd#ConsolidatedBalanceSheetsParenthetical"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_StatementofFinancialPositionParentheticalAbstract_b04d72fd-48bf-429d-9fc3-cb88d5617a05" xlink:href="xers-20201231.xsd#xers_StatementofFinancialPositionParentheticalAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_928b666d-43af-42a6-8ff3-30e8e0d9ebd9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockParOrStatedValuePerShare"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_StatementofFinancialPositionParentheticalAbstract_b04d72fd-48bf-429d-9fc3-cb88d5617a05" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_928b666d-43af-42a6-8ff3-30e8e0d9ebd9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_fc75e6ca-7c0a-41cc-8a13-44c80b5b132d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_StatementofFinancialPositionParentheticalAbstract_b04d72fd-48bf-429d-9fc3-cb88d5617a05" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_fc75e6ca-7c0a-41cc-8a13-44c80b5b132d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_9619b08e-6a43-459d-b544-f949e1007d97" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockSharesAuthorized"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_StatementofFinancialPositionParentheticalAbstract_b04d72fd-48bf-429d-9fc3-cb88d5617a05" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_9619b08e-6a43-459d-b544-f949e1007d97" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_362413f1-ee9c-408d-ae98-7e6566ea5586" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_StatementofFinancialPositionParentheticalAbstract_b04d72fd-48bf-429d-9fc3-cb88d5617a05" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_362413f1-ee9c-408d-ae98-7e6566ea5586" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesIssued_bb4b4ae6-4560-4411-bd82-b804ac83a879" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockSharesIssued"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_StatementofFinancialPositionParentheticalAbstract_b04d72fd-48bf-429d-9fc3-cb88d5617a05" xlink:to="loc_us-gaap_PreferredStockSharesIssued_bb4b4ae6-4560-4411-bd82-b804ac83a879" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_fc71e102-b171-4a12-841f-9651229f6262" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_StatementofFinancialPositionParentheticalAbstract_b04d72fd-48bf-429d-9fc3-cb88d5617a05" xlink:to="loc_us-gaap_CommonStockSharesIssued_fc71e102-b171-4a12-841f-9651229f6262" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/ConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="simple" xlink:href="xers-20201231.xsd#ConsolidatedStatementsofOperationsandComprehensiveLoss"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/ConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_StatementsofOperationsAbstract_373e6d7f-e9a0-4a23-8892-268decbcaf80" xlink:href="xers-20201231.xsd#xers_StatementsofOperationsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_880c3051-e423-4ecb-996a-b19c00dac00e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_StatementsofOperationsAbstract_373e6d7f-e9a0-4a23-8892-268decbcaf80" xlink:to="loc_us-gaap_StatementTable_880c3051-e423-4ecb-996a-b19c00dac00e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RestatementAxis_0c3e243b-9807-423b-8110-922bde9bd638" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RestatementAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_880c3051-e423-4ecb-996a-b19c00dac00e" xlink:to="loc_srt_RestatementAxis_0c3e243b-9807-423b-8110-922bde9bd638" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RestatementDomain_6292f583-d617-4eeb-a1a4-2db8c78f6834" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RestatementDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RestatementAxis_0c3e243b-9807-423b-8110-922bde9bd638" xlink:to="loc_srt_RestatementDomain_6292f583-d617-4eeb-a1a4-2db8c78f6834" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_eaf0333a-1f44-4a3c-a639-3111c9d37beb" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_880c3051-e423-4ecb-996a-b19c00dac00e" xlink:to="loc_srt_ProductOrServiceAxis_eaf0333a-1f44-4a3c-a639-3111c9d37beb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_6f0cf35f-31cf-4a00-806f-3a048b685ce7" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_eaf0333a-1f44-4a3c-a639-3111c9d37beb" xlink:to="loc_srt_ProductsAndServicesDomain_6f0cf35f-31cf-4a00-806f-3a048b685ce7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_5f94a7a5-7337-4a41-b067-dab5129eb4ab" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_880c3051-e423-4ecb-996a-b19c00dac00e" xlink:to="loc_us-gaap_StatementLineItems_5f94a7a5-7337-4a41-b067-dab5129eb4ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_7276d2fd-2ad5-435a-bb63-ecb83a5bc1f7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5f94a7a5-7337-4a41-b067-dab5129eb4ab" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_7276d2fd-2ad5-435a-bb63-ecb83a5bc1f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Grantincome_6c8b3576-198e-4901-b5d0-0069ee4e8bf5" xlink:href="xers-20201231.xsd#xers_Grantincome"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5f94a7a5-7337-4a41-b067-dab5129eb4ab" xlink:to="loc_xers_Grantincome_6c8b3576-198e-4901-b5d0-0069ee4e8bf5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_0c3f5596-fdcf-4572-b0c8-9052b4f4f80c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5f94a7a5-7337-4a41-b067-dab5129eb4ab" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_0c3f5596-fdcf-4572-b0c8-9052b4f4f80c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_4de3dc6c-eb1b-4de7-a4b8-f01e5c930521" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GrossProfit"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5f94a7a5-7337-4a41-b067-dab5129eb4ab" xlink:to="loc_us-gaap_GrossProfit_4de3dc6c-eb1b-4de7-a4b8-f01e5c930521" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpensesAbstract_91e867bf-7e63-490d-a6ed-e3463da8301e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingExpensesAbstract"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5f94a7a5-7337-4a41-b067-dab5129eb4ab" xlink:to="loc_us-gaap_OperatingExpensesAbstract_91e867bf-7e63-490d-a6ed-e3463da8301e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_a05fb240-a06c-44b8-ab2a-ffd92ba30f74" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingExpensesAbstract_91e867bf-7e63-490d-a6ed-e3463da8301e" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_a05fb240-a06c-44b8-ab2a-ffd92ba30f74" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_1acb4d9e-18ae-4479-9aa8-96362bc5272e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingExpensesAbstract_91e867bf-7e63-490d-a6ed-e3463da8301e" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_1acb4d9e-18ae-4479-9aa8-96362bc5272e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_6b5aa6fd-5878-4ea1-80fe-9b42f4dc5b2e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingExpensesAbstract_91e867bf-7e63-490d-a6ed-e3463da8301e" xlink:to="loc_us-gaap_OperatingExpenses_6b5aa6fd-5878-4ea1-80fe-9b42f4dc5b2e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_b81ed85d-0207-4ae0-b6b3-0818ac89626f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingExpensesAbstract_91e867bf-7e63-490d-a6ed-e3463da8301e" xlink:to="loc_us-gaap_OperatingIncomeLoss_b81ed85d-0207-4ae0-b6b3-0818ac89626f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherIncomeAndExpensesAbstract_e001bcf9-5e20-4582-88c3-6447e57554d2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherIncomeAndExpensesAbstract"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5f94a7a5-7337-4a41-b067-dab5129eb4ab" xlink:to="loc_us-gaap_OtherIncomeAndExpensesAbstract_e001bcf9-5e20-4582-88c3-6447e57554d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeOther_8ae182d1-9705-4bfc-9d1a-42abcb3dcc76" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestIncomeOther"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAndExpensesAbstract_e001bcf9-5e20-4582-88c3-6447e57554d2" xlink:to="loc_us-gaap_InterestIncomeOther_8ae182d1-9705-4bfc-9d1a-42abcb3dcc76" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_dcae6d8b-09ad-4192-a83b-ca12eead5fb1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestExpense"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAndExpensesAbstract_e001bcf9-5e20-4582-88c3-6447e57554d2" xlink:to="loc_us-gaap_InterestExpense_dcae6d8b-09ad-4192-a83b-ca12eead5fb1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_bccca6f2-beab-406c-a2b8-d3a168e0fedb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueAdjustmentOfWarrants"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAndExpensesAbstract_e001bcf9-5e20-4582-88c3-6447e57554d2" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_bccca6f2-beab-406c-a2b8-d3a168e0fedb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_1ed0bb81-17ee-48fd-956e-0bfa8b781ef1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherIncomeAndExpensesAbstract_e001bcf9-5e20-4582-88c3-6447e57554d2" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_1ed0bb81-17ee-48fd-956e-0bfa8b781ef1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossAttributableToParent_246b43ca-ddcd-4338-b705-db0ac8f2c2f0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossAttributableToParent"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5f94a7a5-7337-4a41-b067-dab5129eb4ab" xlink:to="loc_us-gaap_IncomeLossAttributableToParent_246b43ca-ddcd-4338-b705-db0ac8f2c2f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_a5e4e2fd-8762-4a1b-a3e1-3a5b7d0945ef" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5f94a7a5-7337-4a41-b067-dab5129eb4ab" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_a5e4e2fd-8762-4a1b-a3e1-3a5b7d0945ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_c50e8aaa-3abc-4558-92a4-e31aa1ed5fe3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5f94a7a5-7337-4a41-b067-dab5129eb4ab" xlink:to="loc_us-gaap_NetIncomeLoss_c50e8aaa-3abc-4558-92a4-e31aa1ed5fe3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_a10712d8-8d3d-4302-8259-069dd66e9ae0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5f94a7a5-7337-4a41-b067-dab5129eb4ab" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_a10712d8-8d3d-4302-8259-069dd66e9ae0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax_ca1daf22-d64f-4542-a78e-d090d135c70f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_a10712d8-8d3d-4302-8259-069dd66e9ae0" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax_ca1daf22-d64f-4542-a78e-d090d135c70f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax_75b4369c-b11b-40d8-b8c2-2e05b55f3a0c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_a10712d8-8d3d-4302-8259-069dd66e9ae0" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax_75b4369c-b11b-40d8-b8c2-2e05b55f3a0c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_60c9f687-3996-49fa-8935-8dd4fdf98348" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_a10712d8-8d3d-4302-8259-069dd66e9ae0" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_60c9f687-3996-49fa-8935-8dd4fdf98348" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasicAndDiluted_d5cad015-4abc-4043-be5b-bcf666090db2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EarningsPerShareBasicAndDiluted"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5f94a7a5-7337-4a41-b067-dab5129eb4ab" xlink:to="loc_us-gaap_EarningsPerShareBasicAndDiluted_d5cad015-4abc-4043-be5b-bcf666090db2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted_cd88ff26-1afd-409d-aa7c-c636e6571c98" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5f94a7a5-7337-4a41-b067-dab5129eb4ab" xlink:to="loc_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted_cd88ff26-1afd-409d-aa7c-c636e6571c98" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/StatementsofStockholdersEquity" xlink:type="simple" xlink:href="xers-20201231.xsd#StatementsofStockholdersEquity"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/StatementsofStockholdersEquity" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_StatementofConvertiblePreferredStockandStockholdersEquityDeficitAbstract_8f743a24-a54e-41d8-9f74-ad3014704a79" xlink:href="xers-20201231.xsd#xers_StatementofConvertiblePreferredStockandStockholdersEquityDeficitAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_f90bb252-ea11-4dae-9d7f-8ef1ab0db6cd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_StatementofConvertiblePreferredStockandStockholdersEquityDeficitAbstract_8f743a24-a54e-41d8-9f74-ad3014704a79" xlink:to="loc_us-gaap_StatementTable_f90bb252-ea11-4dae-9d7f-8ef1ab0db6cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_7752b362-188c-4b3d-99a5-0ca714c71aef" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_f90bb252-ea11-4dae-9d7f-8ef1ab0db6cd" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_7752b362-188c-4b3d-99a5-0ca714c71aef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_b90b7cd4-562a-4a50-b978-961ed4bb6fca" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_7752b362-188c-4b3d-99a5-0ca714c71aef" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_b90b7cd4-562a-4a50-b978-961ed4bb6fca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_efe7c0b5-015b-47ce-9b74-caee0a182322" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_b90b7cd4-562a-4a50-b978-961ed4bb6fca" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_efe7c0b5-015b-47ce-9b74-caee0a182322" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_3765ad6a-3409-477a-9ffa-2b58a0a8edba" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_f90bb252-ea11-4dae-9d7f-8ef1ab0db6cd" xlink:to="loc_us-gaap_StatementClassOfStockAxis_3765ad6a-3409-477a-9ffa-2b58a0a8edba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_0d62b02b-c8c1-42ed-ae6c-eba0ca7d2304" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_3765ad6a-3409-477a-9ffa-2b58a0a8edba" xlink:to="loc_us-gaap_ClassOfStockDomain_0d62b02b-c8c1-42ed-ae6c-eba0ca7d2304" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_8017bd7b-fd23-4f72-b315-28c695cfeceb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_0d62b02b-c8c1-42ed-ae6c-eba0ca7d2304" xlink:to="loc_us-gaap_CommonStockMember_8017bd7b-fd23-4f72-b315-28c695cfeceb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_26a8bb39-cc4f-48b7-888e-1ddb8e5d850e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_f90bb252-ea11-4dae-9d7f-8ef1ab0db6cd" xlink:to="loc_us-gaap_StatementLineItems_26a8bb39-cc4f-48b7-888e-1ddb8e5d850e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_5a9f3ac1-1671-40df-bbe1-0d5a83da7488" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_26a8bb39-cc4f-48b7-888e-1ddb8e5d850e" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_5a9f3ac1-1671-40df-bbe1-0d5a83da7488" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_99158c7a-ea57-4ee4-b879-0f22cbe22fc5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_26a8bb39-cc4f-48b7-888e-1ddb8e5d850e" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_99158c7a-ea57-4ee4-b879-0f22cbe22fc5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_1b227a1f-3c2a-4bd4-ac43-55a8bee09340" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_99158c7a-ea57-4ee4-b879-0f22cbe22fc5" xlink:to="loc_us-gaap_CommonStockValue_1b227a1f-3c2a-4bd4-ac43-55a8bee09340" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_54b9fd60-691c-4089-abda-9e29d3cc0915" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_99158c7a-ea57-4ee4-b879-0f22cbe22fc5" xlink:to="loc_us-gaap_AdditionalPaidInCapital_54b9fd60-691c-4089-abda-9e29d3cc0915" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_8887081a-33d7-4b54-9f74-1227ab940a6f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_99158c7a-ea57-4ee4-b879-0f22cbe22fc5" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_8887081a-33d7-4b54-9f74-1227ab940a6f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_203f54cc-4d97-44fa-b949-9e0f3a03bf22" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_99158c7a-ea57-4ee4-b879-0f22cbe22fc5" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_203f54cc-4d97-44fa-b949-9e0f3a03bf22" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_75b2b1d4-4795-4bc9-a787-83853c167a88" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_99158c7a-ea57-4ee4-b879-0f22cbe22fc5" xlink:to="loc_us-gaap_StockholdersEquity_75b2b1d4-4795-4bc9-a787-83853c167a88" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_8263e235-f8ab-4cbf-b37f-56a4f4328166" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_99158c7a-ea57-4ee4-b879-0f22cbe22fc5" xlink:to="loc_us-gaap_NetIncomeLoss_8263e235-f8ab-4cbf-b37f-56a4f4328166" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_9c87d157-0b20-469f-ba42-fe25f8e9a7eb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_99158c7a-ea57-4ee4-b879-0f22cbe22fc5" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_9c87d157-0b20-469f-ba42-fe25f8e9a7eb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_ca7d5a02-237d-42da-8f60-2afbe3e3c834" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_99158c7a-ea57-4ee4-b879-0f22cbe22fc5" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_ca7d5a02-237d-42da-8f60-2afbe3e3c834" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_01e209a5-1d5c-4351-87f9-f172bf151bc6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_99158c7a-ea57-4ee4-b879-0f22cbe22fc5" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_01e209a5-1d5c-4351-87f9-f172bf151bc6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_198659b5-fced-40ee-8238-e324147f50c8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_99158c7a-ea57-4ee4-b879-0f22cbe22fc5" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_198659b5-fced-40ee-8238-e324147f50c8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_79362c63-c205-4bbf-9397-87c5a91aecf0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_99158c7a-ea57-4ee4-b879-0f22cbe22fc5" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_79362c63-c205-4bbf-9397-87c5a91aecf0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationAndExerciseOfStockOptions_789292ee-e99c-4db1-8a14-822dc48362d0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationAndExerciseOfStockOptions"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_99158c7a-ea57-4ee4-b879-0f22cbe22fc5" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationAndExerciseOfStockOptions_789292ee-e99c-4db1-8a14-822dc48362d0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Warrantsexercisesinperiod_8c6a24c5-751a-4976-8cd8-c730abb75f19" xlink:href="xers-20201231.xsd#xers_Warrantsexercisesinperiod"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_99158c7a-ea57-4ee4-b879-0f22cbe22fc5" xlink:to="loc_xers_Warrantsexercisesinperiod_8c6a24c5-751a-4976-8cd8-c730abb75f19" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Warrantsexercisesinperiodvalue_dd8507bd-8944-4d16-9358-e3f9ee474bb9" xlink:href="xers-20201231.xsd#xers_Warrantsexercisesinperiodvalue"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_99158c7a-ea57-4ee4-b879-0f22cbe22fc5" xlink:to="loc_xers_Warrantsexercisesinperiodvalue_dd8507bd-8944-4d16-9358-e3f9ee474bb9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_StockIssuedDuringPeriodSharesVestingOfRestrictedStockUnits_7899e099-318e-4a4e-882a-011164740598" xlink:href="xers-20201231.xsd#xers_StockIssuedDuringPeriodSharesVestingOfRestrictedStockUnits"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_99158c7a-ea57-4ee4-b879-0f22cbe22fc5" xlink:to="loc_xers_StockIssuedDuringPeriodSharesVestingOfRestrictedStockUnits_7899e099-318e-4a4e-882a-011164740598" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_PaymentsRelatedToTaxWithholdingForShareBasedCompensationRSUs_33bcb75d-9302-4786-91a9-19fccc574cb0" xlink:href="xers-20201231.xsd#xers_PaymentsRelatedToTaxWithholdingForShareBasedCompensationRSUs"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_99158c7a-ea57-4ee4-b879-0f22cbe22fc5" xlink:to="loc_xers_PaymentsRelatedToTaxWithholdingForShareBasedCompensationRSUs_33bcb75d-9302-4786-91a9-19fccc574cb0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_07774fef-4bd5-4709-953a-49aab0c3cb6f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_99158c7a-ea57-4ee4-b879-0f22cbe22fc5" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_07774fef-4bd5-4709-953a-49aab0c3cb6f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_e43307f9-c530-466a-ba14-ba8278786b41" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_99158c7a-ea57-4ee4-b879-0f22cbe22fc5" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_e43307f9-c530-466a-ba14-ba8278786b41" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_06ab43cd-2290-4f65-af4b-f20e85afe365" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_99158c7a-ea57-4ee4-b879-0f22cbe22fc5" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_06ab43cd-2290-4f65-af4b-f20e85afe365" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_4ba7c700-d6c0-4f60-abb6-b02c83731ea9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_99158c7a-ea57-4ee4-b879-0f22cbe22fc5" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_4ba7c700-d6c0-4f60-abb6-b02c83731ea9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/StatementofCashFlows" xlink:type="simple" xlink:href="xers-20201231.xsd#StatementofCashFlows"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/StatementofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_e5f0c993-827e-4bbd-b000-dac83c1c2fc9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementOfCashFlowsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_f772dd0f-5cc1-4567-a7fe-613e11da94fd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_e5f0c993-827e-4bbd-b000-dac83c1c2fc9" xlink:to="loc_us-gaap_StatementTable_f772dd0f-5cc1-4567-a7fe-613e11da94fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RestatementAxis_7f6aaa3f-97b4-407f-b7fb-e1b2ae0a40a6" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RestatementAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_f772dd0f-5cc1-4567-a7fe-613e11da94fd" xlink:to="loc_srt_RestatementAxis_7f6aaa3f-97b4-407f-b7fb-e1b2ae0a40a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RestatementDomain_fc924fdc-2a55-4645-9a70-c31480996aeb" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RestatementDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RestatementAxis_7f6aaa3f-97b4-407f-b7fb-e1b2ae0a40a6" xlink:to="loc_srt_RestatementDomain_fc924fdc-2a55-4645-9a70-c31480996aeb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_706e81e4-6392-47e3-878d-3375b819fc1b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_f772dd0f-5cc1-4567-a7fe-613e11da94fd" xlink:to="loc_us-gaap_StatementLineItems_706e81e4-6392-47e3-878d-3375b819fc1b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_317c00c3-485e-42ae-a9ca-0262ee387744" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_706e81e4-6392-47e3-878d-3375b819fc1b" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_317c00c3-485e-42ae-a9ca-0262ee387744" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_c5652080-3f72-4f95-aee3-23bcc5122b36" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_317c00c3-485e-42ae-a9ca-0262ee387744" xlink:to="loc_us-gaap_NetIncomeLoss_c5652080-3f72-4f95-aee3-23bcc5122b36" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_90eb9f21-eb6f-4c7e-8eae-38d70b6bd8f4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_706e81e4-6392-47e3-878d-3375b819fc1b" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_90eb9f21-eb6f-4c7e-8eae-38d70b6bd8f4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_e3336e6a-34bf-430c-9f2f-07b8e287c0c8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_90eb9f21-eb6f-4c7e-8eae-38d70b6bd8f4" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_e3336e6a-34bf-430c-9f2f-07b8e287c0c8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_aa04965a-a14f-41fd-9782-b2229730b533" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_90eb9f21-eb6f-4c7e-8eae-38d70b6bd8f4" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_aa04965a-a14f-41fd-9782-b2229730b533" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_4fd47946-2d28-42d1-a1b9-e3bcd8e72493" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_90eb9f21-eb6f-4c7e-8eae-38d70b6bd8f4" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_4fd47946-2d28-42d1-a1b9-e3bcd8e72493" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_fe36e663-453c-457d-adbf-3917326d1473" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_90eb9f21-eb6f-4c7e-8eae-38d70b6bd8f4" xlink:to="loc_us-gaap_ShareBasedCompensation_fe36e663-453c-457d-adbf-3917326d1473" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_GainsLossesOnConversionOfConvertibleDebt_4bc6e48d-8646-4c8e-a279-1642d6e06e6e" xlink:href="xers-20201231.xsd#xers_GainsLossesOnConversionOfConvertibleDebt"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_90eb9f21-eb6f-4c7e-8eae-38d70b6bd8f4" xlink:to="loc_xers_GainsLossesOnConversionOfConvertibleDebt_4bc6e48d-8646-4c8e-a279-1642d6e06e6e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_5c54b27d-1b25-4a24-bb3b-581174535ee6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_90eb9f21-eb6f-4c7e-8eae-38d70b6bd8f4" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_5c54b27d-1b25-4a24-bb3b-581174535ee6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_36675ada-d48c-4512-925f-2f7b961da193" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueAdjustmentOfWarrants"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_90eb9f21-eb6f-4c7e-8eae-38d70b6bd8f4" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_36675ada-d48c-4512-925f-2f7b961da193" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssetsAbstract_b89ecb05-883b-4e46-987a-65aa1381ba53" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssetsAbstract"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_706e81e4-6392-47e3-878d-3375b819fc1b" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssetsAbstract_b89ecb05-883b-4e46-987a-65aa1381ba53" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_0221d378-e6c5-44e6-b7b6-83d23a08f80d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssetsAbstract_b89ecb05-883b-4e46-987a-65aa1381ba53" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_0221d378-e6c5-44e6-b7b6-83d23a08f80d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidExpense_1410e2ab-1bdb-4607-9a78-eb3ad69ccc45" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidExpense"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssetsAbstract_b89ecb05-883b-4e46-987a-65aa1381ba53" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidExpense_1410e2ab-1bdb-4607-9a78-eb3ad69ccc45" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_601c1f04-9309-43d1-92a2-97f3ee454429" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssetsAbstract_b89ecb05-883b-4e46-987a-65aa1381ba53" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_601c1f04-9309-43d1-92a2-97f3ee454429" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_50b4b812-0fde-4860-9e10-5ed0d5706b9f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssetsAbstract_b89ecb05-883b-4e46-987a-65aa1381ba53" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_50b4b812-0fde-4860-9e10-5ed0d5706b9f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_a10a80fd-20ea-4d4d-a219-e9ab77eca8e3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssetsAbstract_b89ecb05-883b-4e46-987a-65aa1381ba53" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_a10a80fd-20ea-4d4d-a219-e9ab77eca8e3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Accruedtradediscountsandrebates_f121696b-b4c4-4e65-a3cb-1e95380c51e0" xlink:href="xers-20201231.xsd#xers_Accruedtradediscountsandrebates"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssetsAbstract_b89ecb05-883b-4e46-987a-65aa1381ba53" xlink:to="loc_xers_Accruedtradediscountsandrebates_f121696b-b4c4-4e65-a3cb-1e95380c51e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Increaseinaccruedreturnsreserve_c88acc6c-f65c-4307-8842-76c6549c48ca" xlink:href="xers-20201231.xsd#xers_Increaseinaccruedreturnsreserve"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssetsAbstract_b89ecb05-883b-4e46-987a-65aa1381ba53" xlink:to="loc_xers_Increaseinaccruedreturnsreserve_c88acc6c-f65c-4307-8842-76c6549c48ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredLiabilities_916cfde7-c062-4404-b576-45cdb3ec1082" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredLiabilities"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssetsAbstract_b89ecb05-883b-4e46-987a-65aa1381ba53" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredLiabilities_916cfde7-c062-4404-b576-45cdb3ec1082" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_dda27ae3-b087-49ce-a2bc-f0a1f4da17cd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingLiabilities"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssetsAbstract_b89ecb05-883b-4e46-987a-65aa1381ba53" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_dda27ae3-b087-49ce-a2bc-f0a1f4da17cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_54eaf07c-191f-4913-bed0-55c548d3aaff" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssetsAbstract_b89ecb05-883b-4e46-987a-65aa1381ba53" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_54eaf07c-191f-4913-bed0-55c548d3aaff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_90e642f1-1c62-4a71-84ad-e764a59ef63a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_706e81e4-6392-47e3-878d-3375b819fc1b" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_90e642f1-1c62-4a71-84ad-e764a59ef63a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_7d8b3ef6-7496-4fb3-9b86-bb9fb1fafba0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_90e642f1-1c62-4a71-84ad-e764a59ef63a" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_7d8b3ef6-7496-4fb3-9b86-bb9fb1fafba0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireShortTermInvestments_0eec3ef2-78f7-4ac1-b84d-6145612adbe4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquireShortTermInvestments"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_90e642f1-1c62-4a71-84ad-e764a59ef63a" xlink:to="loc_us-gaap_PaymentsToAcquireShortTermInvestments_0eec3ef2-78f7-4ac1-b84d-6145612adbe4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments_2c2809ff-e243-440f-9e64-6d7fb50dbec8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_90e642f1-1c62-4a71-84ad-e764a59ef63a" xlink:to="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments_2c2809ff-e243-440f-9e64-6d7fb50dbec8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d83e6055-eaf8-4c59-9be5-577a5dd3d3f2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_90e642f1-1c62-4a71-84ad-e764a59ef63a" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d83e6055-eaf8-4c59-9be5-577a5dd3d3f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_1ae67d7c-b8c3-47c7-96db-3699316a0dba" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_706e81e4-6392-47e3-878d-3375b819fc1b" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_1ae67d7c-b8c3-47c7-96db-3699316a0dba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_c6c12802-3ddd-40a7-836e-b4917f7359a4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_1ae67d7c-b8c3-47c7-96db-3699316a0dba" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_c6c12802-3ddd-40a7-836e-b4917f7359a4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_5ca68dee-8131-4abc-a105-7d90415ff5ec" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsOfStockIssuanceCosts"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_1ae67d7c-b8c3-47c7-96db-3699316a0dba" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_5ca68dee-8131-4abc-a105-7d90415ff5ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_7066fe1b-f1d2-45cf-8f27-2a30c7705476" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_1ae67d7c-b8c3-47c7-96db-3699316a0dba" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_7066fe1b-f1d2-45cf-8f27-2a30c7705476" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfSecuredDebt_5bace5a3-e07e-4384-878e-6dbf0086cf6e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RepaymentsOfSecuredDebt"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_1ae67d7c-b8c3-47c7-96db-3699316a0dba" xlink:to="loc_us-gaap_RepaymentsOfSecuredDebt_5bace5a3-e07e-4384-878e-6dbf0086cf6e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_a9a77b55-bcd1-4fbb-b9b0-22282b6ee12a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsOfDebtIssuanceCosts"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_1ae67d7c-b8c3-47c7-96db-3699316a0dba" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_a9a77b55-bcd1-4fbb-b9b0-22282b6ee12a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_PaymentsOfDebtConversionCosts_943619f7-7f57-47af-9c47-d2e5ea460933" xlink:href="xers-20201231.xsd#xers_PaymentsOfDebtConversionCosts"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_1ae67d7c-b8c3-47c7-96db-3699316a0dba" xlink:to="loc_xers_PaymentsOfDebtConversionCosts_943619f7-7f57-47af-9c47-d2e5ea460933" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockPlans_c27ca873-aeaf-4519-9989-5f5ed01948b2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromStockPlans"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_1ae67d7c-b8c3-47c7-96db-3699316a0dba" xlink:to="loc_us-gaap_ProceedsFromStockPlans_c27ca873-aeaf-4519-9989-5f5ed01948b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_38ac9c30-5d8d-40e3-aaab-eed6d0d624f3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_1ae67d7c-b8c3-47c7-96db-3699316a0dba" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_38ac9c30-5d8d-40e3-aaab-eed6d0d624f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_3b9e05a5-1dab-4e84-8c23-5b36d996d34f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_1ae67d7c-b8c3-47c7-96db-3699316a0dba" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_3b9e05a5-1dab-4e84-8c23-5b36d996d34f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_b085c80d-3a56-44b4-a286-f1e0d41001f5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_1ae67d7c-b8c3-47c7-96db-3699316a0dba" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_b085c80d-3a56-44b4-a286-f1e0d41001f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_c79d5fab-da7c-4c74-9fd0-7e705a7bf70d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_1ae67d7c-b8c3-47c7-96db-3699316a0dba" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_c79d5fab-da7c-4c74-9fd0-7e705a7bf70d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_6639222f-0818-46b1-903a-6e182776cd9e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_1ae67d7c-b8c3-47c7-96db-3699316a0dba" xlink:to="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_6639222f-0818-46b1-903a-6e182776cd9e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_d8966f2d-f602-4813-8560-54f51be411ba" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_1ae67d7c-b8c3-47c7-96db-3699316a0dba" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_d8966f2d-f602-4813-8560-54f51be411ba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_0fbfc9b5-accc-459b-b16d-a5dee11c011d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_1ae67d7c-b8c3-47c7-96db-3699316a0dba" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_0fbfc9b5-accc-459b-b16d-a5dee11c011d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_6959605e-1847-4a1a-ad8a-3073aa10eb50" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SupplementalCashFlowInformationAbstract"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_706e81e4-6392-47e3-878d-3375b819fc1b" xlink:to="loc_us-gaap_SupplementalCashFlowInformationAbstract_6959605e-1847-4a1a-ad8a-3073aa10eb50" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPaidNet_b162f5e7-bdc3-4c62-80e2-7c9a9edbc683" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestPaidNet"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_6959605e-1847-4a1a-ad8a-3073aa10eb50" xlink:to="loc_us-gaap_InterestPaidNet_b162f5e7-bdc3-4c62-80e2-7c9a9edbc683" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalCashFlowElementsAndSupplementalCashFlowInformationAbstract_0cc541e8-d48a-4c4a-b684-2ff6b3def858" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdditionalCashFlowElementsAndSupplementalCashFlowInformationAbstract"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_706e81e4-6392-47e3-878d-3375b819fc1b" xlink:to="loc_us-gaap_AdditionalCashFlowElementsAndSupplementalCashFlowInformationAbstract_0cc541e8-d48a-4c4a-b684-2ff6b3def858" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Noncashtenantimprovementallowance_9c4eff55-abfc-47fb-b3fc-349689a57181" xlink:href="xers-20201231.xsd#xers_Noncashtenantimprovementallowance"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdditionalCashFlowElementsAndSupplementalCashFlowInformationAbstract_0cc541e8-d48a-4c4a-b684-2ff6b3def858" xlink:to="loc_xers_Noncashtenantimprovementallowance_9c4eff55-abfc-47fb-b3fc-349689a57181" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_NoncashIssuanceOfStockForConversionOfDebt_7701b803-03bb-4dbd-aeb8-7a1e980cbc23" xlink:href="xers-20201231.xsd#xers_NoncashIssuanceOfStockForConversionOfDebt"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdditionalCashFlowElementsAndSupplementalCashFlowInformationAbstract_0cc541e8-d48a-4c4a-b684-2ff6b3def858" xlink:to="loc_xers_NoncashIssuanceOfStockForConversionOfDebt_7701b803-03bb-4dbd-aeb8-7a1e980cbc23" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtIssuanceCostsIncurredDuringNoncashOrPartialNoncashTransaction_69210038-af5b-4113-a3ba-ac6beb4110ee" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtIssuanceCostsIncurredDuringNoncashOrPartialNoncashTransaction"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdditionalCashFlowElementsAndSupplementalCashFlowInformationAbstract_0cc541e8-d48a-4c4a-b684-2ff6b3def858" xlink:to="loc_us-gaap_DebtIssuanceCostsIncurredDuringNoncashOrPartialNoncashTransaction_69210038-af5b-4113-a3ba-ac6beb4110ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/OrganizationandNatureoftheBusiness" xlink:type="simple" xlink:href="xers-20201231.xsd#OrganizationandNatureoftheBusiness"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/OrganizationandNatureoftheBusiness" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_83c477e8-7172-4898-9fa2-068cd8b87842" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NatureOfOperations_fa562a3d-3e61-412f-a525-6719af7655cf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NatureOfOperations"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_83c477e8-7172-4898-9fa2-068cd8b87842" xlink:to="loc_us-gaap_NatureOfOperations_fa562a3d-3e61-412f-a525-6719af7655cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/OrganizationandNatureoftheBusinessNarrativeDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#OrganizationandNatureoftheBusinessNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/OrganizationandNatureoftheBusinessNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_d9305887-9fcf-4ecf-82b2-cad7e98c3534" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_a79b59ea-5900-41a9-94f7-cdc362e5dc3f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_d9305887-9fcf-4ecf-82b2-cad7e98c3534" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_a79b59ea-5900-41a9-94f7-cdc362e5dc3f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_d7766acb-3061-40fd-be2b-fdc70bb56a77" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_d9305887-9fcf-4ecf-82b2-cad7e98c3534" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_d7766acb-3061-40fd-be2b-fdc70bb56a77" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/SummaryofSignificantAccountingPolicies" xlink:type="simple" xlink:href="xers-20201231.xsd#SummaryofSignificantAccountingPolicies"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/SummaryofSignificantAccountingPolicies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_SummaryofSignificantAccountingPoliciesAbstract_cc13a161-93b0-4135-9aa6-e4f40a386460" xlink:href="xers-20201231.xsd#xers_SummaryofSignificantAccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SignificantAccountingPoliciesTextBlock_94d9f203-0e51-48b5-9deb-ecd6e7285c5e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SignificantAccountingPoliciesTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_SummaryofSignificantAccountingPoliciesAbstract_cc13a161-93b0-4135-9aa6-e4f40a386460" xlink:to="loc_us-gaap_SignificantAccountingPoliciesTextBlock_94d9f203-0e51-48b5-9deb-ecd6e7285c5e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/SummaryofSignificantAccountingPoliciesPolicies" xlink:type="simple" xlink:href="xers-20201231.xsd#SummaryofSignificantAccountingPoliciesPolicies"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/SummaryofSignificantAccountingPoliciesPolicies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_SummaryofSignificantAccountingPoliciesAbstract_f3fffc52-b8ce-493a-a3c9-aca69b792299" xlink:href="xers-20201231.xsd#xers_SummaryofSignificantAccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRecognitionSalesOfGoods_0ef6d957-688c-4ead-a595-4ae2ba2ae153" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenueRecognitionSalesOfGoods"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_SummaryofSignificantAccountingPoliciesAbstract_f3fffc52-b8ce-493a-a3c9-aca69b792299" xlink:to="loc_us-gaap_RevenueRecognitionSalesOfGoods_0ef6d957-688c-4ead-a595-4ae2ba2ae153" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesTradeAndOtherAccountsReceivableAllowanceForDoubtfulAccountsPolicy_7c282020-7c0e-4cec-8162-6e0b6c615818" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ReceivablesTradeAndOtherAccountsReceivableAllowanceForDoubtfulAccountsPolicy"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_SummaryofSignificantAccountingPoliciesAbstract_f3fffc52-b8ce-493a-a3c9-aca69b792299" xlink:to="loc_us-gaap_ReceivablesTradeAndOtherAccountsReceivableAllowanceForDoubtfulAccountsPolicy_7c282020-7c0e-4cec-8162-6e0b6c615818" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskCreditRisk_46891222-c07f-4823-967d-8c90618cec74" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConcentrationRiskCreditRisk"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_SummaryofSignificantAccountingPoliciesAbstract_f3fffc52-b8ce-493a-a3c9-aca69b792299" xlink:to="loc_us-gaap_ConcentrationRiskCreditRisk_46891222-c07f-4823-967d-8c90618cec74" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfSalesPolicyTextBlock_7d558f9b-9ab0-41ff-a6ed-49209c3eb14e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CostOfSalesPolicyTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_SummaryofSignificantAccountingPoliciesAbstract_f3fffc52-b8ce-493a-a3c9-aca69b792299" xlink:to="loc_us-gaap_CostOfSalesPolicyTextBlock_7d558f9b-9ab0-41ff-a6ed-49209c3eb14e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingPolicyPolicyTextBlock_c46186df-da6f-438b-bd2d-0d4e0d884344" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SegmentReportingPolicyPolicyTextBlock"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_SummaryofSignificantAccountingPoliciesAbstract_f3fffc52-b8ce-493a-a3c9-aca69b792299" xlink:to="loc_us-gaap_SegmentReportingPolicyPolicyTextBlock_c46186df-da6f-438b-bd2d-0d4e0d884344" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_2805c5c8-25c3-49b3-805a-40849d558942" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashAndCashEquivalentsPolicyTextBlock"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_SummaryofSignificantAccountingPoliciesAbstract_f3fffc52-b8ce-493a-a3c9-aca69b792299" xlink:to="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_2805c5c8-25c3-49b3-805a-40849d558942" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryPolicyTextBlock_2c19462d-5908-4270-bd91-983bf1c7eab4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryPolicyTextBlock"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_SummaryofSignificantAccountingPoliciesAbstract_f3fffc52-b8ce-493a-a3c9-aca69b792299" xlink:to="loc_us-gaap_InventoryPolicyTextBlock_2c19462d-5908-4270-bd91-983bf1c7eab4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentPolicyTextBlock_48d4b8e4-bd59-4c55-8885-3cba35b7aa9b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InvestmentPolicyTextBlock"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_SummaryofSignificantAccountingPoliciesAbstract_f3fffc52-b8ce-493a-a3c9-aca69b792299" xlink:to="loc_us-gaap_InvestmentPolicyTextBlock_48d4b8e4-bd59-4c55-8885-3cba35b7aa9b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_5cb9c54d-894e-4da7-bee4-06b37fa40c70" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueMeasurementPolicyPolicyTextBlock"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_SummaryofSignificantAccountingPoliciesAbstract_f3fffc52-b8ce-493a-a3c9-aca69b792299" xlink:to="loc_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_5cb9c54d-894e-4da7-bee4-06b37fa40c70" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_ba27f1ea-5d12-43a6-8136-413611e1964b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentPolicyTextBlock"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_SummaryofSignificantAccountingPoliciesAbstract_f3fffc52-b8ce-493a-a3c9-aca69b792299" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_ba27f1ea-5d12-43a6-8136-413611e1964b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock_f502ea80-c1bd-44bc-b2c6-ece38b56d582" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_SummaryofSignificantAccountingPoliciesAbstract_f3fffc52-b8ce-493a-a3c9-aca69b792299" xlink:to="loc_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock_f502ea80-c1bd-44bc-b2c6-ece38b56d582" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_4bf15caf-1d04-4846-8a3b-a81cb0dbf543" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ResearchAndDevelopmentExpensePolicy"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_SummaryofSignificantAccountingPoliciesAbstract_f3fffc52-b8ce-493a-a3c9-aca69b792299" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_4bf15caf-1d04-4846-8a3b-a81cb0dbf543" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_e4869eec-52aa-4d8d-b09e-c32867a10bb3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_SummaryofSignificantAccountingPoliciesAbstract_f3fffc52-b8ce-493a-a3c9-aca69b792299" xlink:to="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_e4869eec-52aa-4d8d-b09e-c32867a10bb3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxPolicyTextBlock_92249c8b-8b01-4891-b685-04a975a6ed1e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxPolicyTextBlock"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_SummaryofSignificantAccountingPoliciesAbstract_f3fffc52-b8ce-493a-a3c9-aca69b792299" xlink:to="loc_us-gaap_IncomeTaxPolicyTextBlock_92249c8b-8b01-4891-b685-04a975a6ed1e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock_f137d0cb-ec63-4eeb-8c2e-33b0e99c88f7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_SummaryofSignificantAccountingPoliciesAbstract_f3fffc52-b8ce-493a-a3c9-aca69b792299" xlink:to="loc_us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock_f137d0cb-ec63-4eeb-8c2e-33b0e99c88f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_9aeb43ef-67eb-48ef-a546-7ac999cdf107" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ComprehensiveIncomePolicyPolicyTextBlock"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_SummaryofSignificantAccountingPoliciesAbstract_f3fffc52-b8ce-493a-a3c9-aca69b792299" xlink:to="loc_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_9aeb43ef-67eb-48ef-a546-7ac999cdf107" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PriorPeriodReclassificationAdjustmentDescription_a36e0c0e-ef39-4b2c-a590-5ea5ed035acb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PriorPeriodReclassificationAdjustmentDescription"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_SummaryofSignificantAccountingPoliciesAbstract_f3fffc52-b8ce-493a-a3c9-aca69b792299" xlink:to="loc_us-gaap_PriorPeriodReclassificationAdjustmentDescription_a36e0c0e-ef39-4b2c-a590-5ea5ed035acb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_76e1a4f7-c6a3-4d7b-906d-6154b21ec331" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_SummaryofSignificantAccountingPoliciesAbstract_f3fffc52-b8ce-493a-a3c9-aca69b792299" xlink:to="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_76e1a4f7-c6a3-4d7b-906d-6154b21ec331" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/SummaryofSignificantAccountingPoliciesTables" xlink:type="simple" xlink:href="xers-20201231.xsd#SummaryofSignificantAccountingPoliciesTables"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/SummaryofSignificantAccountingPoliciesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_SummaryofSignificantAccountingPoliciesAbstract_2a4c175c-d582-416b-a3d2-a784ba561746" xlink:href="xers-20201231.xsd#xers_SummaryofSignificantAccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_ff19dd3d-8176-40d8-a61d-7bb156a3cca5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_SummaryofSignificantAccountingPoliciesAbstract_2a4c175c-d582-416b-a3d2-a784ba561746" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_ff19dd3d-8176-40d8-a61d-7bb156a3cca5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_77d9132a-b48b-49a3-9763-d69bfb8635c1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_ff19dd3d-8176-40d8-a61d-7bb156a3cca5" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_77d9132a-b48b-49a3-9763-d69bfb8635c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_feeaab39-a0e8-496a-9a73-576dbdf91b72" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_77d9132a-b48b-49a3-9763-d69bfb8635c1" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_feeaab39-a0e8-496a-9a73-576dbdf91b72" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_f6752912-2336-4c2b-9111-5daaf58efd9e" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_ff19dd3d-8176-40d8-a61d-7bb156a3cca5" xlink:to="loc_srt_RangeAxis_f6752912-2336-4c2b-9111-5daaf58efd9e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_b81aa284-90c0-4eab-9f6e-b5ae6a8acf02" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_f6752912-2336-4c2b-9111-5daaf58efd9e" xlink:to="loc_srt_RangeMember_b81aa284-90c0-4eab-9f6e-b5ae6a8acf02" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cd3deb62-d2d6-4114-a918-d613c7870c84" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_ff19dd3d-8176-40d8-a61d-7bb156a3cca5" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cd3deb62-d2d6-4114-a918-d613c7870c84" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_ScheduleofPropertyandEquipmentUsefulLivesTableTextBlock_ed917dff-156b-4c96-84d1-75f5eb3288a6" xlink:href="xers-20201231.xsd#xers_ScheduleofPropertyandEquipmentUsefulLivesTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cd3deb62-d2d6-4114-a918-d613c7870c84" xlink:to="loc_xers_ScheduleofPropertyandEquipmentUsefulLivesTableTextBlock_ed917dff-156b-4c96-84d1-75f5eb3288a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/SummaryofSignificantAccountingPoliciesNarrativeDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#SummaryofSignificantAccountingPoliciesNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/SummaryofSignificantAccountingPoliciesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_166b3056-19e1-4bed-880d-863f33b64075" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_9be6d700-faee-4149-be57-3c9f6d38a72e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_166b3056-19e1-4bed-880d-863f33b64075" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_9be6d700-faee-4149-be57-3c9f6d38a72e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_af7f8559-0c86-4c6c-90a1-a64628ea054a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_9be6d700-faee-4149-be57-3c9f6d38a72e" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_af7f8559-0c86-4c6c-90a1-a64628ea054a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_40c1af25-9547-443b-a6b8-8f000ad260fc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_af7f8559-0c86-4c6c-90a1-a64628ea054a" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_40c1af25-9547-443b-a6b8-8f000ad260fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MachineryAndEquipmentMember_b9b14d9a-abcd-44cb-8698-d73f1fa5a2e5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_MachineryAndEquipmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_40c1af25-9547-443b-a6b8-8f000ad260fc" xlink:to="loc_us-gaap_MachineryAndEquipmentMember_b9b14d9a-abcd-44cb-8698-d73f1fa5a2e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComputerEquipmentMember_b9ee5bf3-95fb-42f1-9a5a-dabb0a900355" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ComputerEquipmentMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_40c1af25-9547-443b-a6b8-8f000ad260fc" xlink:to="loc_us-gaap_ComputerEquipmentMember_b9ee5bf3-95fb-42f1-9a5a-dabb0a900355" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_62006e93-2758-4e40-b6b3-d73bac01bb83" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LeaseholdImprovementsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_40c1af25-9547-443b-a6b8-8f000ad260fc" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_62006e93-2758-4e40-b6b3-d73bac01bb83" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_SoftwareDomain_8f05596d-3a0c-4835-98f0-030f8670ef1f" xlink:href="xers-20201231.xsd#xers_SoftwareDomain"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_40c1af25-9547-443b-a6b8-8f000ad260fc" xlink:to="loc_xers_SoftwareDomain_8f05596d-3a0c-4835-98f0-030f8670ef1f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_2e5616ad-545d-4e06-be0b-1f5b0ef3a03d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FurnitureAndFixturesMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_40c1af25-9547-443b-a6b8-8f000ad260fc" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_2e5616ad-545d-4e06-be0b-1f5b0ef3a03d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OfficeEquipmentMember_4d5fbdc4-a296-4016-b7ec-17db8ee497f2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OfficeEquipmentMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_40c1af25-9547-443b-a6b8-8f000ad260fc" xlink:to="loc_us-gaap_OfficeEquipmentMember_4d5fbdc4-a296-4016-b7ec-17db8ee497f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_e483d7bf-c772-4e08-8818-edc10ab26f26" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_9be6d700-faee-4149-be57-3c9f6d38a72e" xlink:to="loc_srt_RangeAxis_e483d7bf-c772-4e08-8818-edc10ab26f26" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_864e3f03-1254-4bde-ad3d-19af00ab0308" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_e483d7bf-c772-4e08-8818-edc10ab26f26" xlink:to="loc_srt_RangeMember_864e3f03-1254-4bde-ad3d-19af00ab0308" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_624a4cc7-f071-4565-b2e3-2ba382b30d72" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_864e3f03-1254-4bde-ad3d-19af00ab0308" xlink:to="loc_srt_MinimumMember_624a4cc7-f071-4565-b2e3-2ba382b30d72" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_e2494e0c-aec3-433d-9a2f-89ee6a8f2810" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_864e3f03-1254-4bde-ad3d-19af00ab0308" xlink:to="loc_srt_MaximumMember_e2494e0c-aec3-433d-9a2f-89ee6a8f2810" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_575e28ce-1591-49d2-9b85-f5cfc30cdd13" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_9be6d700-faee-4149-be57-3c9f6d38a72e" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_575e28ce-1591-49d2-9b85-f5cfc30cdd13" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_46432fae-81d1-4963-8fd3-b7263721f7f6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_575e28ce-1591-49d2-9b85-f5cfc30cdd13" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_46432fae-81d1-4963-8fd3-b7263721f7f6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_54be3004-d4c6-4a3c-a248-a6b4af4e878a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_46432fae-81d1-4963-8fd3-b7263721f7f6" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_54be3004-d4c6-4a3c-a248-a6b4af4e878a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_619628cc-5be6-46d0-ba2e-8a6ddf5a621a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_9be6d700-faee-4149-be57-3c9f6d38a72e" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentLineItems_619628cc-5be6-46d0-ba2e-8a6ddf5a621a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Concentrationrisknumberofmajorcustomers_ab4e9e90-faff-4a9e-abb5-53bfdb60fd8a" xlink:href="xers-20201231.xsd#xers_Concentrationrisknumberofmajorcustomers"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_619628cc-5be6-46d0-ba2e-8a6ddf5a621a" xlink:to="loc_xers_Concentrationrisknumberofmajorcustomers_ab4e9e90-faff-4a9e-abb5-53bfdb60fd8a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_25514b36-65fc-47ef-8be8-74d2582d33a6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_619628cc-5be6-46d0-ba2e-8a6ddf5a621a" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_25514b36-65fc-47ef-8be8-74d2582d33a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentEstimatedUsefulLives_25225040-543a-45f9-9b2f-121723403a51" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentEstimatedUsefulLives"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_619628cc-5be6-46d0-ba2e-8a6ddf5a621a" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentEstimatedUsefulLives_25225040-543a-45f9-9b2f-121723403a51" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_89fe458e-907d-4794-a991-23be53ba4ba1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsOfStockIssuanceCosts"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_619628cc-5be6-46d0-ba2e-8a6ddf5a621a" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_89fe458e-907d-4794-a991-23be53ba4ba1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Capitalizedcostspublicofferingcosts_a474466f-1a87-44d3-bceb-08f0be4cfad1" xlink:href="xers-20201231.xsd#xers_Capitalizedcostspublicofferingcosts"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_166b3056-19e1-4bed-880d-863f33b64075" xlink:to="loc_xers_Capitalizedcostspublicofferingcosts_a474466f-1a87-44d3-bceb-08f0be4cfad1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_AChangeOfReturnsReservePercentage_147a1c8e-d124-4f47-b16f-8f54be365160" xlink:href="xers-20201231.xsd#xers_AChangeOfReturnsReservePercentage"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_166b3056-19e1-4bed-880d-863f33b64075" xlink:to="loc_xers_AChangeOfReturnsReservePercentage_147a1c8e-d124-4f47-b16f-8f54be365160" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_ImpactOnRevenueIfReturnsReserveChangedBy1_22b82e39-24b1-4539-a073-0f6597f86496" xlink:href="xers-20201231.xsd#xers_ImpactOnRevenueIfReturnsReserveChangedBy1"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_166b3056-19e1-4bed-880d-863f33b64075" xlink:to="loc_xers_ImpactOnRevenueIfReturnsReserveChangedBy1_22b82e39-24b1-4539-a073-0f6597f86496" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_ConcentrationRiskPercentageofGrossRevenue_bff5843f-b7cf-4590-8d12-fb1d6e4853ab" xlink:href="xers-20201231.xsd#xers_ConcentrationRiskPercentageofGrossRevenue"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_166b3056-19e1-4bed-880d-863f33b64075" xlink:to="loc_xers_ConcentrationRiskPercentageofGrossRevenue_bff5843f-b7cf-4590-8d12-fb1d6e4853ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_ConcentrationRiskPercentageofAccountsReceivable_38c6de4d-dc1e-45a7-b9a5-ec787c2ad507" xlink:href="xers-20201231.xsd#xers_ConcentrationRiskPercentageofAccountsReceivable"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_166b3056-19e1-4bed-880d-863f33b64075" xlink:to="loc_xers_ConcentrationRiskPercentageofAccountsReceivable_38c6de4d-dc1e-45a7-b9a5-ec787c2ad507" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_63590b74-35c5-4461-85da-f91884cf8444" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsOfStockIssuanceCosts"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_166b3056-19e1-4bed-880d-863f33b64075" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_63590b74-35c5-4461-85da-f91884cf8444" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/SummaryofSignificantAccountingPoliciesSummaryofAccountingPoliciesDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#SummaryofSignificantAccountingPoliciesSummaryofAccountingPoliciesDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/SummaryofSignificantAccountingPoliciesSummaryofAccountingPoliciesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_925d9039-839b-4131-9680-8b54ba44a448" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Concentrationrisknumberofmajorcustomers_bead3a21-8203-4874-a01d-0c43ffca67f5" xlink:href="xers-20201231.xsd#xers_Concentrationrisknumberofmajorcustomers"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_925d9039-839b-4131-9680-8b54ba44a448" xlink:to="loc_xers_Concentrationrisknumberofmajorcustomers_bead3a21-8203-4874-a01d-0c43ffca67f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_ConcentrationRiskPercentageofGrossRevenue_3690ecc2-6f50-4476-a7ba-17d0df250897" xlink:href="xers-20201231.xsd#xers_ConcentrationRiskPercentageofGrossRevenue"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_925d9039-839b-4131-9680-8b54ba44a448" xlink:to="loc_xers_ConcentrationRiskPercentageofGrossRevenue_3690ecc2-6f50-4476-a7ba-17d0df250897" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_97ca2b1d-addb-492a-b3f4-07a9bf93f196" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsOfStockIssuanceCosts"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_925d9039-839b-4131-9680-8b54ba44a448" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_97ca2b1d-addb-492a-b3f4-07a9bf93f196" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_ConcentrationRiskPercentageofAccountsReceivable_d3e84cb2-284e-4a65-bfde-c506430db284" xlink:href="xers-20201231.xsd#xers_ConcentrationRiskPercentageofAccountsReceivable"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_925d9039-839b-4131-9680-8b54ba44a448" xlink:to="loc_xers_ConcentrationRiskPercentageofAccountsReceivable_d3e84cb2-284e-4a65-bfde-c506430db284" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/InventoryNotes" xlink:type="simple" xlink:href="xers-20201231.xsd#InventoryNotes"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/InventoryNotes" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryDisclosureAbstract_e835dbec-c13e-4b35-a0b3-eb79c1ba2b47" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryCurrentTable_7ba283d6-cebd-464e-b87a-820622bf985c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryCurrentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_e835dbec-c13e-4b35-a0b3-eb79c1ba2b47" xlink:to="loc_us-gaap_InventoryCurrentTable_7ba283d6-cebd-464e-b87a-820622bf985c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PublicUtilitiesInventoryAxis_be5610df-f514-47da-ab62-11f20430efee" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PublicUtilitiesInventoryAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryCurrentTable_7ba283d6-cebd-464e-b87a-820622bf985c" xlink:to="loc_us-gaap_PublicUtilitiesInventoryAxis_be5610df-f514-47da-ab62-11f20430efee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PublicUtilitiesInventoryTypeDomain_8b4b2050-6ea2-44a9-86db-8cbdc8dd190d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PublicUtilitiesInventoryTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PublicUtilitiesInventoryAxis_be5610df-f514-47da-ab62-11f20430efee" xlink:to="loc_us-gaap_PublicUtilitiesInventoryTypeDomain_8b4b2050-6ea2-44a9-86db-8cbdc8dd190d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryLineItems_e33e7d74-df3b-4de7-9ca7-5749fc94c4d1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryCurrentTable_7ba283d6-cebd-464e-b87a-820622bf985c" xlink:to="loc_us-gaap_InventoryLineItems_e33e7d74-df3b-4de7-9ca7-5749fc94c4d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryDisclosureTextBlock_f73996d7-b2f3-4fd2-aa18-c70480226fa1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryLineItems_e33e7d74-df3b-4de7-9ca7-5749fc94c4d1" xlink:to="loc_us-gaap_InventoryDisclosureTextBlock_f73996d7-b2f3-4fd2-aa18-c70480226fa1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/InventoryTables" xlink:type="simple" xlink:href="xers-20201231.xsd#InventoryTables"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/InventoryTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryDisclosureAbstract_a56c8188-0f23-48f3-80e6-ca1cd0395cf1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryCurrentTable_013fe02e-6e6d-46c7-ab6d-089692c91fcf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryCurrentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_a56c8188-0f23-48f3-80e6-ca1cd0395cf1" xlink:to="loc_us-gaap_InventoryCurrentTable_013fe02e-6e6d-46c7-ab6d-089692c91fcf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PublicUtilitiesInventoryAxis_e80d43b3-b65f-40f9-8dcc-70e8c71d11eb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PublicUtilitiesInventoryAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryCurrentTable_013fe02e-6e6d-46c7-ab6d-089692c91fcf" xlink:to="loc_us-gaap_PublicUtilitiesInventoryAxis_e80d43b3-b65f-40f9-8dcc-70e8c71d11eb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PublicUtilitiesInventoryTypeDomain_35936e36-3295-47f0-9aa9-c6ef7f5b40d7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PublicUtilitiesInventoryTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PublicUtilitiesInventoryAxis_e80d43b3-b65f-40f9-8dcc-70e8c71d11eb" xlink:to="loc_us-gaap_PublicUtilitiesInventoryTypeDomain_35936e36-3295-47f0-9aa9-c6ef7f5b40d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryLineItems_b9722927-c5e4-4437-809a-7486a6ed51d4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryCurrentTable_013fe02e-6e6d-46c7-ab6d-089692c91fcf" xlink:to="loc_us-gaap_InventoryLineItems_b9722927-c5e4-4437-809a-7486a6ed51d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfInventoryCurrentTableTextBlock_cb1106c6-23d5-4276-b932-57f89ee23b16" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfInventoryCurrentTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryLineItems_b9722927-c5e4-4437-809a-7486a6ed51d4" xlink:to="loc_us-gaap_ScheduleOfInventoryCurrentTableTextBlock_cb1106c6-23d5-4276-b932-57f89ee23b16" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/InventoryDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#InventoryDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/InventoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryDisclosureAbstract_ed2aec82-1a6e-47f4-9bc3-85326466b06d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryValuationReserves_e53fda9e-9d2b-4416-bb40-586c1d251624" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryValuationReserves"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_ed2aec82-1a6e-47f4-9bc3-85326466b06d" xlink:to="loc_us-gaap_InventoryValuationReserves_e53fda9e-9d2b-4416-bb40-586c1d251624" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/InventoryComponentsofInventoryDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#InventoryComponentsofInventoryDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/InventoryComponentsofInventoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryDisclosureAbstract_4bcb4d15-34e9-486a-ac6d-74d7504f105a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryCurrentTable_6a2646d2-12ef-41df-afa0-625c0a449d6f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryCurrentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_4bcb4d15-34e9-486a-ac6d-74d7504f105a" xlink:to="loc_us-gaap_InventoryCurrentTable_6a2646d2-12ef-41df-afa0-625c0a449d6f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PublicUtilitiesInventoryAxis_df8884d3-2d69-448c-bf4c-706c956a6d2e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PublicUtilitiesInventoryAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryCurrentTable_6a2646d2-12ef-41df-afa0-625c0a449d6f" xlink:to="loc_us-gaap_PublicUtilitiesInventoryAxis_df8884d3-2d69-448c-bf4c-706c956a6d2e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PublicUtilitiesInventoryTypeDomain_c88b5033-7266-4fce-88a8-bc613857e7ae" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PublicUtilitiesInventoryTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PublicUtilitiesInventoryAxis_df8884d3-2d69-448c-bf4c-706c956a6d2e" xlink:to="loc_us-gaap_PublicUtilitiesInventoryTypeDomain_c88b5033-7266-4fce-88a8-bc613857e7ae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryLineItems_79e99e93-9044-4b3f-97b5-b7b7a98bbca1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryCurrentTable_6a2646d2-12ef-41df-afa0-625c0a449d6f" xlink:to="loc_us-gaap_InventoryLineItems_79e99e93-9044-4b3f-97b5-b7b7a98bbca1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_3de32558-21f3-40c1-ab27-f8ab00fe7522" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryLineItems_79e99e93-9044-4b3f-97b5-b7b7a98bbca1" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_3de32558-21f3-40c1-ab27-f8ab00fe7522" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_ffc1bca7-1206-45a3-8da6-5e1826a655d7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryLineItems_79e99e93-9044-4b3f-97b5-b7b7a98bbca1" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_ffc1bca7-1206-45a3-8da6-5e1826a655d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_905c7fc4-c24c-4055-97d2-b53ffc7d8eaa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryLineItems_79e99e93-9044-4b3f-97b5-b7b7a98bbca1" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_905c7fc4-c24c-4055-97d2-b53ffc7d8eaa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_d66d5366-ac2d-439b-937b-3ebe113a1587" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InventoryNet"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryLineItems_79e99e93-9044-4b3f-97b5-b7b7a98bbca1" xlink:to="loc_us-gaap_InventoryNet_d66d5366-ac2d-439b-937b-3ebe113a1587" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/PropertyandEquipmentNotes" xlink:type="simple" xlink:href="xers-20201231.xsd#PropertyandEquipmentNotes"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/PropertyandEquipmentNotes" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_PropertyandEquipmentAbstract_f5e967ec-fa34-4587-9411-d0e3c4b1a200" xlink:href="xers-20201231.xsd#xers_PropertyandEquipmentAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock_9f17eff2-67b8-40d2-aaf5-96556eaec35b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_PropertyandEquipmentAbstract_f5e967ec-fa34-4587-9411-d0e3c4b1a200" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock_9f17eff2-67b8-40d2-aaf5-96556eaec35b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/PropertyandEquipmentTables" xlink:type="simple" xlink:href="xers-20201231.xsd#PropertyandEquipmentTables"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/PropertyandEquipmentTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_PropertyandEquipmentAbstract_8c2d8e08-5eb9-40b1-b0b1-2bac56e3e9f5" xlink:href="xers-20201231.xsd#xers_PropertyandEquipmentAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_12c55119-178e-44bf-8363-c607603501e0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_PropertyandEquipmentAbstract_8c2d8e08-5eb9-40b1-b0b1-2bac56e3e9f5" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_12c55119-178e-44bf-8363-c607603501e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/PropertyandEquipmentDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#PropertyandEquipmentDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/PropertyandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_PropertyandEquipmentAbstract_00a65c76-351d-4987-a894-9a994b26d420" xlink:href="xers-20201231.xsd#xers_PropertyandEquipmentAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_98f8ffde-7303-4c3a-ad13-5cc6905e8915" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_PropertyandEquipmentAbstract_00a65c76-351d-4987-a894-9a994b26d420" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_98f8ffde-7303-4c3a-ad13-5cc6905e8915" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_2f73f9fb-148a-4be3-8591-7b6742e4b866" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_98f8ffde-7303-4c3a-ad13-5cc6905e8915" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_2f73f9fb-148a-4be3-8591-7b6742e4b866" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_c71a4547-b74d-4ad7-9b55-be864bda5f32" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_2f73f9fb-148a-4be3-8591-7b6742e4b866" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_c71a4547-b74d-4ad7-9b55-be864bda5f32" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MachineryAndEquipmentMember_19acf14e-277c-4010-8ec9-2cead962768c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_MachineryAndEquipmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_c71a4547-b74d-4ad7-9b55-be864bda5f32" xlink:to="loc_us-gaap_MachineryAndEquipmentMember_19acf14e-277c-4010-8ec9-2cead962768c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_1c32932b-367a-42a4-92fc-f61cd8abde59" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FurnitureAndFixturesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_c71a4547-b74d-4ad7-9b55-be864bda5f32" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_1c32932b-367a-42a4-92fc-f61cd8abde59" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComputerEquipmentMember_9f5750a5-7733-4df2-95e4-85b8f42f8b25" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ComputerEquipmentMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_c71a4547-b74d-4ad7-9b55-be864bda5f32" xlink:to="loc_us-gaap_ComputerEquipmentMember_9f5750a5-7733-4df2-95e4-85b8f42f8b25" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OfficeEquipmentMember_f737db0c-3ef2-41cd-a6c6-726381bfc47f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OfficeEquipmentMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_c71a4547-b74d-4ad7-9b55-be864bda5f32" xlink:to="loc_us-gaap_OfficeEquipmentMember_f737db0c-3ef2-41cd-a6c6-726381bfc47f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_SoftwareDomain_7a398ece-85b2-43be-9e5c-8350c27bce97" xlink:href="xers-20201231.xsd#xers_SoftwareDomain"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_c71a4547-b74d-4ad7-9b55-be864bda5f32" xlink:to="loc_xers_SoftwareDomain_7a398ece-85b2-43be-9e5c-8350c27bce97" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_dd8ea848-e1e8-4cdd-b8c7-963f78ee3e0a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LeaseholdImprovementsMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_c71a4547-b74d-4ad7-9b55-be864bda5f32" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_dd8ea848-e1e8-4cdd-b8c7-963f78ee3e0a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3b80feb1-4b29-4d8d-8b29-cdbd7bafd79e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_98f8ffde-7303-4c3a-ad13-5cc6905e8915" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3b80feb1-4b29-4d8d-8b29-cdbd7bafd79e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_17f2e065-502c-4c2f-8eb6-fb9879e91f20" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3b80feb1-4b29-4d8d-8b29-cdbd7bafd79e" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_17f2e065-502c-4c2f-8eb6-fb9879e91f20" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_dc852d90-e85d-4307-8cf6-0db2ae450b3a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3b80feb1-4b29-4d8d-8b29-cdbd7bafd79e" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_dc852d90-e85d-4307-8cf6-0db2ae450b3a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_ebe33282-f3b6-4712-a970-63417460cbd3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_3b80feb1-4b29-4d8d-8b29-cdbd7bafd79e" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_ebe33282-f3b6-4712-a970-63417460cbd3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/PropertyandEquipmentPropertyandequipmentdetailsDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#PropertyandEquipmentPropertyandequipmentdetailsDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/PropertyandEquipmentPropertyandequipmentdetailsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_47d9469d-750e-42d1-97ba-c117cf4702ef" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_DepreciationDepletionandAmortizationnotincludingassetimpairments_76253d9b-7e03-4a2d-9872-42f2ccb37f2c" xlink:href="xers-20201231.xsd#xers_DepreciationDepletionandAmortizationnotincludingassetimpairments"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_47d9469d-750e-42d1-97ba-c117cf4702ef" xlink:to="loc_xers_DepreciationDepletionandAmortizationnotincludingassetimpairments_76253d9b-7e03-4a2d-9872-42f2ccb37f2c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/OtherAccruedLiabilitiesNotes" xlink:type="simple" xlink:href="xers-20201231.xsd#OtherAccruedLiabilitiesNotes"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/OtherAccruedLiabilitiesNotes" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_AccruedExpensesAbstract_6bed4751-32c8-4627-8b07-854b0f0b7b72" xlink:href="xers-20201231.xsd#xers_AccruedExpensesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAccruedLiabilitiesAndOtherLiabilitiesDisclosureCurrentTextBlock_4d893591-5fe3-4acb-8fdb-23dfc7a5772d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsPayableAccruedLiabilitiesAndOtherLiabilitiesDisclosureCurrentTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_AccruedExpensesAbstract_6bed4751-32c8-4627-8b07-854b0f0b7b72" xlink:to="loc_us-gaap_AccountsPayableAccruedLiabilitiesAndOtherLiabilitiesDisclosureCurrentTextBlock_4d893591-5fe3-4acb-8fdb-23dfc7a5772d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/OtherAccruedLiabilitiesTables" xlink:type="simple" xlink:href="xers-20201231.xsd#OtherAccruedLiabilitiesTables"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/OtherAccruedLiabilitiesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_AccruedExpensesAbstract_d77abad4-cab9-4c8c-81d3-f6ed1d75bc59" xlink:href="xers-20201231.xsd#xers_AccruedExpensesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_AccruedExpensesTableTextBlock_5ba5a320-b908-4ea0-8fba-67679fa80733" xlink:href="xers-20201231.xsd#xers_AccruedExpensesTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_AccruedExpensesAbstract_d77abad4-cab9-4c8c-81d3-f6ed1d75bc59" xlink:to="loc_xers_AccruedExpensesTableTextBlock_5ba5a320-b908-4ea0-8fba-67679fa80733" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/OtherAccruedLiabilitiesOtherAccruedLiabilitiesDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#OtherAccruedLiabilitiesOtherAccruedLiabilitiesDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/OtherAccruedLiabilitiesOtherAccruedLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_AccruedExpensesAbstract_1e26fc26-e74a-4271-a4d6-b91620f88e02" xlink:href="xers-20201231.xsd#xers_AccruedExpensesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_37c88efa-8593-4fa9-aa7d-b04dd4581f1a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_AccruedExpensesAbstract_1e26fc26-e74a-4271-a4d6-b91620f88e02" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_37c88efa-8593-4fa9-aa7d-b04dd4581f1a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_AccruedSupplyChainCosts_e948c530-8f2a-4dec-8422-27cfe75d6fc7" xlink:href="xers-20201231.xsd#xers_AccruedSupplyChainCosts"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_AccruedExpensesAbstract_1e26fc26-e74a-4271-a4d6-b91620f88e02" xlink:to="loc_xers_AccruedSupplyChainCosts_e948c530-8f2a-4dec-8422-27cfe75d6fc7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedMarketingCostsCurrent_c389dfac-9079-4e72-88b8-2198291e73cf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedMarketingCostsCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_AccruedExpensesAbstract_1e26fc26-e74a-4271-a4d6-b91620f88e02" xlink:to="loc_us-gaap_AccruedMarketingCostsCurrent_c389dfac-9079-4e72-88b8-2198291e73cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Accruedresearchcosts_60728c1d-781e-4630-a2dc-ada350347d6d" xlink:href="xers-20201231.xsd#xers_Accruedresearchcosts"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_AccruedExpensesAbstract_1e26fc26-e74a-4271-a4d6-b91620f88e02" xlink:to="loc_xers_Accruedresearchcosts_60728c1d-781e-4630-a2dc-ada350347d6d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveCurrent_0faee159-a751-439b-ad7e-fcfb643658a4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringReserveCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_AccruedExpensesAbstract_1e26fc26-e74a-4271-a4d6-b91620f88e02" xlink:to="loc_us-gaap_RestructuringReserveCurrent_0faee159-a751-439b-ad7e-fcfb643658a4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPayableCurrent_5ccb1d66-3dd7-4ade-8eb6-9a40ae674264" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestPayableCurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_AccruedExpensesAbstract_1e26fc26-e74a-4271-a4d6-b91620f88e02" xlink:to="loc_us-gaap_InterestPayableCurrent_5ccb1d66-3dd7-4ade-8eb6-9a40ae674264" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_e1db0970-7cf3-4508-9b4c-543ce249a295" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_AccruedExpensesAbstract_1e26fc26-e74a-4271-a4d6-b91620f88e02" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_e1db0970-7cf3-4508-9b4c-543ce249a295" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_c6e1c860-04f0-45ce-b791-86594a305305" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_AccruedExpensesAbstract_1e26fc26-e74a-4271-a4d6-b91620f88e02" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_c6e1c860-04f0-45ce-b791-86594a305305" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/LongTermDebt" xlink:type="simple" xlink:href="xers-20201231.xsd#LongTermDebt"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/LongTermDebt" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAbstract_6f4df8ae-ad05-4959-8617-01d448b01ad2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtTextBlock_4430fc1c-818f-4609-9f70-c139145b399a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongTermDebtAbstract_6f4df8ae-ad05-4959-8617-01d448b01ad2" xlink:to="loc_us-gaap_LongTermDebtTextBlock_4430fc1c-818f-4609-9f70-c139145b399a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/LongTermDebtTables" xlink:type="simple" xlink:href="xers-20201231.xsd#LongTermDebtTables"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/LongTermDebtTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAbstract_5ce7a2c4-f56c-4808-a68b-4ccc4056f5bd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDebtInstrumentsTextBlock_58f63bc6-495a-4504-b7a5-4a68d6bdbf39" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfDebtInstrumentsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongTermDebtAbstract_5ce7a2c4-f56c-4808-a68b-4ccc4056f5bd" xlink:to="loc_us-gaap_ScheduleOfDebtInstrumentsTextBlock_58f63bc6-495a-4504-b7a5-4a68d6bdbf39" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfMaturitiesOfLongTermDebtTableTextBlock_80c574d6-a16b-45c0-9169-ea79976ebfdf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfMaturitiesOfLongTermDebtTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongTermDebtAbstract_5ce7a2c4-f56c-4808-a68b-4ccc4056f5bd" xlink:to="loc_us-gaap_ScheduleOfMaturitiesOfLongTermDebtTableTextBlock_80c574d6-a16b-45c0-9169-ea79976ebfdf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/LongTermDebtDebtFuturePrincipalPaymentsDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#LongTermDebtDebtFuturePrincipalPaymentsDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/LongTermDebtDebtFuturePrincipalPaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_fc486d47-712a-4c8a-9559-681fb0aac8a2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_5f9bb4ff-4e1a-4954-9d7b-1fc9be79f75f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtAndCapitalLeaseObligationsMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_fc486d47-712a-4c8a-9559-681fb0aac8a2" xlink:to="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_5f9bb4ff-4e1a-4954-9d7b-1fc9be79f75f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsMaturitiesRepaymentsOfPrincipalInYearTwo_8fb0b10b-0ceb-4af0-a8cb-aba7f4b4cae4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtAndCapitalLeaseObligationsMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_fc486d47-712a-4c8a-9559-681fb0aac8a2" xlink:to="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsMaturitiesRepaymentsOfPrincipalInYearTwo_8fb0b10b-0ceb-4af0-a8cb-aba7f4b4cae4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsMaturitiesRepaymentsOfPrincipalInYearThree_694df3c6-c44d-4a9e-a513-e0e7d4ddb16a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtAndCapitalLeaseObligationsMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_fc486d47-712a-4c8a-9559-681fb0aac8a2" xlink:to="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsMaturitiesRepaymentsOfPrincipalInYearThree_694df3c6-c44d-4a9e-a513-e0e7d4ddb16a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsMaturitiesRepaymentsOfPrincipalInYearFour_df852949-8ed1-4a57-ab0f-3a6202729c48" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtAndCapitalLeaseObligationsMaturitiesRepaymentsOfPrincipalInYearFour"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_fc486d47-712a-4c8a-9559-681fb0aac8a2" xlink:to="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsMaturitiesRepaymentsOfPrincipalInYearFour_df852949-8ed1-4a57-ab0f-3a6202729c48" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsMaturitiesRepaymentsOfPrincipalAfterYearFive_f76ee370-ef85-437b-95f8-00ed18b0c355" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtAndCapitalLeaseObligationsMaturitiesRepaymentsOfPrincipalAfterYearFive"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_fc486d47-712a-4c8a-9559-681fb0aac8a2" xlink:to="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsMaturitiesRepaymentsOfPrincipalAfterYearFive_f76ee370-ef85-437b-95f8-00ed18b0c355" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_873a0a00-b306-4ee3-8254-d96081ef4183" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_fc486d47-712a-4c8a-9559-681fb0aac8a2" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_873a0a00-b306-4ee3-8254-d96081ef4183" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/LongTermDebtNarrativeDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#LongTermDebtNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/LongTermDebtNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAbstract_0ac5ab62-2239-4ffa-9df6-201a831680a6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_d7236e06-6556-41ef-b688-9ef892f87cf4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongTermDebtAbstract_0ac5ab62-2239-4ffa-9df6-201a831680a6" xlink:to="loc_us-gaap_DebtInstrumentTable_d7236e06-6556-41ef-b688-9ef892f87cf4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_9136cfc7-890d-40fe-9c23-22d30172127d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_d7236e06-6556-41ef-b688-9ef892f87cf4" xlink:to="loc_us-gaap_DebtInstrumentAxis_9136cfc7-890d-40fe-9c23-22d30172127d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_8963a612-9bde-46f0-bee9-f7f39f3c3e63" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_9136cfc7-890d-40fe-9c23-22d30172127d" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_8963a612-9bde-46f0-bee9-f7f39f3c3e63" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_A2018TermALoanMember_4740f567-8b03-45d9-90f4-edd771ef4ae2" xlink:href="xers-20201231.xsd#xers_A2018TermALoanMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_8963a612-9bde-46f0-bee9-f7f39f3c3e63" xlink:to="loc_xers_A2018TermALoanMember_4740f567-8b03-45d9-90f4-edd771ef4ae2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_A2018TermBLoanMember_bb23ccf7-0120-4e51-87c3-b8910c215e55" xlink:href="xers-20201231.xsd#xers_A2018TermBLoanMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_8963a612-9bde-46f0-bee9-f7f39f3c3e63" xlink:to="loc_xers_A2018TermBLoanMember_bb23ccf7-0120-4e51-87c3-b8910c215e55" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_A2018LoanandSecurityAgreementMember_82452496-1480-4141-834d-71d1c2f8bcbb" xlink:href="xers-20201231.xsd#xers_A2018LoanandSecurityAgreementMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_8963a612-9bde-46f0-bee9-f7f39f3c3e63" xlink:to="loc_xers_A2018LoanandSecurityAgreementMember_82452496-1480-4141-834d-71d1c2f8bcbb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_AmendedLoanandSecurityAgreementMember_1cc842d6-cd58-41be-a6bd-f671f1cda646" xlink:href="xers-20201231.xsd#xers_AmendedLoanandSecurityAgreementMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_8963a612-9bde-46f0-bee9-f7f39f3c3e63" xlink:to="loc_xers_AmendedLoanandSecurityAgreementMember_1cc842d6-cd58-41be-a6bd-f671f1cda646" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_TermALoanMember_889d3fc3-7bf9-47ba-9e1f-da4eed5dfdaa" xlink:href="xers-20201231.xsd#xers_TermALoanMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_8963a612-9bde-46f0-bee9-f7f39f3c3e63" xlink:to="loc_xers_TermALoanMember_889d3fc3-7bf9-47ba-9e1f-da4eed5dfdaa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_TermBLoanMember_68cfde0b-17b4-4d9b-aadc-e8a19286e8b5" xlink:href="xers-20201231.xsd#xers_TermBLoanMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_8963a612-9bde-46f0-bee9-f7f39f3c3e63" xlink:to="loc_xers_TermBLoanMember_68cfde0b-17b4-4d9b-aadc-e8a19286e8b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_TermCLoanMember_fe3c608e-472b-4359-9aaf-772d7dc6962a" xlink:href="xers-20201231.xsd#xers_TermCLoanMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_8963a612-9bde-46f0-bee9-f7f39f3c3e63" xlink:to="loc_xers_TermCLoanMember_fe3c608e-472b-4359-9aaf-772d7dc6962a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_A2018TermABLoansMember_43f57954-a767-46fa-b025-72e199064561" xlink:href="xers-20201231.xsd#xers_A2018TermABLoansMember"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_8963a612-9bde-46f0-bee9-f7f39f3c3e63" xlink:to="loc_xers_A2018TermABLoansMember_43f57954-a767-46fa-b025-72e199064561" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorLoansMember_27894153-10f4-441d-8094-c42b384a8e88" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SeniorLoansMember"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_8963a612-9bde-46f0-bee9-f7f39f3c3e63" xlink:to="loc_us-gaap_SeniorLoansMember_27894153-10f4-441d-8094-c42b384a8e88" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_ConvertibleNotesMember_8f1c9c9b-9b38-4493-aad1-b071d0785d3f" xlink:href="xers-20201231.xsd#xers_ConvertibleNotesMember"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_8963a612-9bde-46f0-bee9-f7f39f3c3e63" xlink:to="loc_xers_ConvertibleNotesMember_8f1c9c9b-9b38-4493-aad1-b071d0785d3f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_PPPLoanMember_001a9e19-76cd-4833-954f-2ccd04b2bf11" xlink:href="xers-20201231.xsd#xers_PPPLoanMember"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_8963a612-9bde-46f0-bee9-f7f39f3c3e63" xlink:to="loc_xers_PPPLoanMember_001a9e19-76cd-4833-954f-2ccd04b2bf11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_TermDLoanMember_fe164013-60c5-45ad-b462-6c674a346722" xlink:href="xers-20201231.xsd#xers_TermDLoanMember"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_8963a612-9bde-46f0-bee9-f7f39f3c3e63" xlink:to="loc_xers_TermDLoanMember_fe164013-60c5-45ad-b462-6c674a346722" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtMember_de9deead-e4c7-4f4a-95b5-15b6f7951160" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtMember"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_8963a612-9bde-46f0-bee9-f7f39f3c3e63" xlink:to="loc_us-gaap_DebtMember_de9deead-e4c7-4f4a-95b5-15b6f7951160" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_aadbb2fa-d6f8-4be2-a5a4-8227a97f8463" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_d7236e06-6556-41ef-b688-9ef892f87cf4" xlink:to="loc_srt_RangeAxis_aadbb2fa-d6f8-4be2-a5a4-8227a97f8463" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_1762c55a-f47e-4e97-9078-90c5f78db7c7" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_aadbb2fa-d6f8-4be2-a5a4-8227a97f8463" xlink:to="loc_srt_RangeMember_1762c55a-f47e-4e97-9078-90c5f78db7c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_a104df25-043e-4e94-8169-f14501b9f684" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MaximumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_1762c55a-f47e-4e97-9078-90c5f78db7c7" xlink:to="loc_srt_MaximumMember_a104df25-043e-4e94-8169-f14501b9f684" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_f59db530-a15c-4c19-a167-bfe37a7fd4bd" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MinimumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_1762c55a-f47e-4e97-9078-90c5f78db7c7" xlink:to="loc_srt_MinimumMember_f59db530-a15c-4c19-a167-bfe37a7fd4bd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_fb26db0f-e035-4011-b6c2-57fda8471646" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueByMeasurementBasisAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_d7236e06-6556-41ef-b688-9ef892f87cf4" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_fb26db0f-e035-4011-b6c2-57fda8471646" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_ce84844d-dbce-44ce-8e0d-65aab5f30518" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_fb26db0f-e035-4011-b6c2-57fda8471646" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_ce84844d-dbce-44ce-8e0d-65aab5f30518" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_1d85b4e3-6c0d-48b4-95e2-632a852f8968" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MaximumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_ce84844d-dbce-44ce-8e0d-65aab5f30518" xlink:to="loc_srt_MaximumMember_1d85b4e3-6c0d-48b4-95e2-632a852f8968" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_8813939e-62af-423b-956e-456248a11154" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MinimumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_ce84844d-dbce-44ce-8e0d-65aab5f30518" xlink:to="loc_srt_MinimumMember_8813939e-62af-423b-956e-456248a11154" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermAxis_4f96fee7-a3c2-4572-b3fc-e1a3f2eafaed" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LeaseContractualTermAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_d7236e06-6556-41ef-b688-9ef892f87cf4" xlink:to="loc_us-gaap_LeaseContractualTermAxis_4f96fee7-a3c2-4572-b3fc-e1a3f2eafaed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermDomain_f3507d67-9f41-4fc7-834a-2d7dda0f8778" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LeaseContractualTermDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeaseContractualTermAxis_4f96fee7-a3c2-4572-b3fc-e1a3f2eafaed" xlink:to="loc_us-gaap_LeaseContractualTermDomain_f3507d67-9f41-4fc7-834a-2d7dda0f8778" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_ChicagoFultonMarketMember_f7b8539e-2ad2-4836-8b7c-e2322cdeeb6a" xlink:href="xers-20201231.xsd#xers_ChicagoFultonMarketMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeaseContractualTermDomain_f3507d67-9f41-4fc7-834a-2d7dda0f8778" xlink:to="loc_xers_ChicagoFultonMarketMember_f7b8539e-2ad2-4836-8b7c-e2322cdeeb6a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_d7236e06-6556-41ef-b688-9ef892f87cf4" xlink:to="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_84dc1e1d-fa47-4c38-accf-77e68e771dc5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_84dc1e1d-fa47-4c38-accf-77e68e771dc5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_2932117e-8add-4174-bc78-094cd15d6647" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_2932117e-8add-4174-bc78-094cd15d6647" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_InterestratethirtydayLIBORplusstatedpercentage_0cc7e576-3efa-43c4-8e8e-7794abcd8453" xlink:href="xers-20201231.xsd#xers_InterestratethirtydayLIBORplusstatedpercentage"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_xers_InterestratethirtydayLIBORplusstatedpercentage_0cc7e576-3efa-43c4-8e8e-7794abcd8453" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_5ba85309-b615-4d58-ad34-a7e86d043fb8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_5ba85309-b615-4d58-ad34-a7e86d043fb8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_3a4550c2-54b5-46c1-8c7a-211844e7bcea" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_3a4550c2-54b5-46c1-8c7a-211844e7bcea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Prepaymentallowedperdebtagreement_99787ac9-4d0d-4e30-8bd9-add1d632050a" xlink:href="xers-20201231.xsd#xers_Prepaymentallowedperdebtagreement"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_xers_Prepaymentallowedperdebtagreement_99787ac9-4d0d-4e30-8bd9-add1d632050a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Prepaymentpenaltypercentage_0dee6608-f078-46ad-a263-0fbd922ded3c" xlink:href="xers-20201231.xsd#xers_Prepaymentpenaltypercentage"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_xers_Prepaymentpenaltypercentage_0dee6608-f078-46ad-a263-0fbd922ded3c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Finalpaymentfeepercentage_a5550509-dac4-4029-abd0-ffa1a5ef6ca9" xlink:href="xers-20201231.xsd#xers_Finalpaymentfeepercentage"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_xers_Finalpaymentfeepercentage_a5550509-dac4-4029-abd0-ffa1a5ef6ca9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsGross_809b3b1a-9463-4b46-a43f-118c9767c949" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredFinanceCostsGross"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_us-gaap_DeferredFinanceCostsGross_809b3b1a-9463-4b46-a43f-118c9767c949" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_323cb653-6597-4575-98b2-fe81ad1b6df8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestExpense"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_us-gaap_InterestExpense_323cb653-6597-4575-98b2-fe81ad1b6df8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_2484c7ac-1292-4561-890d-6f4ffa952b53" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_us-gaap_LongTermDebt_2484c7ac-1292-4561-890d-6f4ffa952b53" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_277bc474-4a49-4c32-b3df-a8e43d83b51e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_277bc474-4a49-4c32-b3df-a8e43d83b51e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentPaymentTerms_5e732b2c-e5b3-4162-b7d3-0ec4592579d9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentPaymentTerms"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_us-gaap_DebtInstrumentPaymentTerms_5e732b2c-e5b3-4162-b7d3-0ec4592579d9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Interestratestatedpercentageplusgreaterofa2.43orbthirtydayLIBOR_18c94192-c223-45c9-bc97-ed79782c125a" xlink:href="xers-20201231.xsd#xers_Interestratestatedpercentageplusgreaterofa2.43orbthirtydayLIBOR"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_xers_Interestratestatedpercentageplusgreaterofa2.43orbthirtydayLIBOR_18c94192-c223-45c9-bc97-ed79782c125a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFee_5408ac05-ad6d-4fb9-925c-c72e8d5cbfd1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentFee"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_us-gaap_DebtInstrumentFee_5408ac05-ad6d-4fb9-925c-c72e8d5cbfd1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnamortizedDebtIssuanceExpense_43e696d8-9b06-4b4f-915e-420c48b1c857" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_UnamortizedDebtIssuanceExpense"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_us-gaap_UnamortizedDebtIssuanceExpense_43e696d8-9b06-4b4f-915e-420c48b1c857" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_CashInterestPerAnnumOnConvertibleNotes_b96123f5-713a-401b-a6ee-bf11c89b1597" xlink:href="xers-20201231.xsd#xers_CashInterestPerAnnumOnConvertibleNotes"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_xers_CashInterestPerAnnumOnConvertibleNotes_b96123f5-713a-401b-a6ee-bf11c89b1597" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_ConvertibleNotesPurchasedDueToExerciseOfUnderwriterOption_acbc14fd-0a79-4941-bdca-4bf36c7f07d7" xlink:href="xers-20201231.xsd#xers_ConvertibleNotesPurchasedDueToExerciseOfUnderwriterOption"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_xers_ConvertibleNotesPurchasedDueToExerciseOfUnderwriterOption_acbc14fd-0a79-4941-bdca-4bf36c7f07d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfNotesPayable_5da59afa-09ab-4a33-8966-fc4638bcd758" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RepaymentsOfNotesPayable"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_us-gaap_RepaymentsOfNotesPayable_5da59afa-09ab-4a33-8966-fc4638bcd758" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesPayable_c30428cf-09b4-4fe0-b1d0-fb06e34df5b4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NotesPayable"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_us-gaap_NotesPayable_c30428cf-09b4-4fe0-b1d0-fb06e34df5b4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_InitialConversionRateForConvertibleNotes_08d83bf8-90bc-4185-82b8-cc54d71dd4bc" xlink:href="xers-20201231.xsd#xers_InitialConversionRateForConvertibleNotes"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_xers_InitialConversionRateForConvertibleNotes_08d83bf8-90bc-4185-82b8-cc54d71dd4bc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_PerPrincipalAmountOfConvertibleNotes_441ba3cf-ed7b-44bb-a960-49ba4ed9a82a" xlink:href="xers-20201231.xsd#xers_PerPrincipalAmountOfConvertibleNotes"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_xers_PerPrincipalAmountOfConvertibleNotes_441ba3cf-ed7b-44bb-a960-49ba4ed9a82a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_7e6a0f1c-12d4-4bec-886a-f01d815ac0ec" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_7e6a0f1c-12d4-4bec-886a-f01d815ac0ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_MaximumConversionRateOfConvertibleNotes_7711f08a-09b0-4661-a2fb-1092a24ef625" xlink:href="xers-20201231.xsd#xers_MaximumConversionRateOfConvertibleNotes"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_xers_MaximumConversionRateOfConvertibleNotes_7711f08a-09b0-4661-a2fb-1092a24ef625" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_PrincipalAmountOfConvertibleNotesConverted_fbecc888-eb90-4c3f-b2e6-f64f7a34ed96" xlink:href="xers-20201231.xsd#xers_PrincipalAmountOfConvertibleNotesConverted"/>
    <link:presentationArc order="25" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_xers_PrincipalAmountOfConvertibleNotesConverted_fbecc888-eb90-4c3f-b2e6-f64f7a34ed96" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_81a8e29c-a7da-453f-acc2-0cbb110e710e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities"/>
    <link:presentationArc order="26" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_81a8e29c-a7da-453f-acc2-0cbb110e710e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_PrincipalAmountOfConvertibleNotesConvertedPrivately_508e72fa-4c56-4484-97aa-b6695610121f" xlink:href="xers-20201231.xsd#xers_PrincipalAmountOfConvertibleNotesConvertedPrivately"/>
    <link:presentationArc order="27" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_xers_PrincipalAmountOfConvertibleNotesConvertedPrivately_508e72fa-4c56-4484-97aa-b6695610121f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_StockIssuedDuringPeriodSharesConversionOfConvertibleSecuritiesPrivatelyExchanged_0089b320-1616-4762-af89-8c68dc472bd8" xlink:href="xers-20201231.xsd#xers_StockIssuedDuringPeriodSharesConversionOfConvertibleSecuritiesPrivatelyExchanged"/>
    <link:presentationArc order="28" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_xers_StockIssuedDuringPeriodSharesConversionOfConvertibleSecuritiesPrivatelyExchanged_0089b320-1616-4762-af89-8c68dc472bd8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_LossOnTheConvertibleNoteExchangeTransactions_925fef7e-8214-4849-adc2-c24b7532b78e" xlink:href="xers-20201231.xsd#xers_LossOnTheConvertibleNoteExchangeTransactions"/>
    <link:presentationArc order="29" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_xers_LossOnTheConvertibleNoteExchangeTransactions_925fef7e-8214-4849-adc2-c24b7532b78e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_FinalPaymentFeeSettledAtClosing_85ca21e7-a4f5-4e9a-9ac2-1c23cbdf8558" xlink:href="xers-20201231.xsd#xers_FinalPaymentFeeSettledAtClosing"/>
    <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_xers_FinalPaymentFeeSettledAtClosing_85ca21e7-a4f5-4e9a-9ac2-1c23cbdf8558" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_PrepaymentFeeSettledAtClosing_25421bc6-f202-439e-8bf8-2db010bb7483" xlink:href="xers-20201231.xsd#xers_PrepaymentFeeSettledAtClosing"/>
    <link:presentationArc order="31" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_xers_PrepaymentFeeSettledAtClosing_25421bc6-f202-439e-8bf8-2db010bb7483" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_MinimumCashBalanceToBeHeldWithLender_fdb68a93-ef9d-474a-8e47-de0e295c2245" xlink:href="xers-20201231.xsd#xers_MinimumCashBalanceToBeHeldWithLender"/>
    <link:presentationArc order="32" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_xers_MinimumCashBalanceToBeHeldWithLender_fdb68a93-ef9d-474a-8e47-de0e295c2245" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_AmendmentFeeToBeSettledAtMaturity_6dd7c3b6-8120-4556-80b1-304a7045b747" xlink:href="xers-20201231.xsd#xers_AmendmentFeeToBeSettledAtMaturity"/>
    <link:presentationArc order="33" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_xers_AmendmentFeeToBeSettledAtMaturity_6dd7c3b6-8120-4556-80b1-304a7045b747" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_WriteOffOfUnamortizedDebtIssuanceCostsDueToPrepaymentOfNote_f55c301b-870d-494a-9596-173267834eb1" xlink:href="xers-20201231.xsd#xers_WriteOffOfUnamortizedDebtIssuanceCostsDueToPrepaymentOfNote"/>
    <link:presentationArc order="34" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_xers_WriteOffOfUnamortizedDebtIssuanceCostsDueToPrepaymentOfNote_f55c301b-870d-494a-9596-173267834eb1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_WriteOffOfPrepaymentFeeDueToPrepaymentOfNote_f6b02acd-2312-408b-944b-5103de98ed92" xlink:href="xers-20201231.xsd#xers_WriteOffOfPrepaymentFeeDueToPrepaymentOfNote"/>
    <link:presentationArc order="35" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_xers_WriteOffOfPrepaymentFeeDueToPrepaymentOfNote_f6b02acd-2312-408b-944b-5103de98ed92" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LettersOfCreditOutstandingAmount_779001bc-6f18-4daf-b6b9-6c13c57ed0f5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LettersOfCreditOutstandingAmount"/>
    <link:presentationArc order="36" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_us-gaap_LettersOfCreditOutstandingAmount_779001bc-6f18-4daf-b6b9-6c13c57ed0f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_62031aa2-bbd5-4e7a-8bce-0729b5ab4339" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:presentationArc order="37" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0a1e7fbf-8895-4e00-ad27-531effae9b64" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_62031aa2-bbd5-4e7a-8bce-0729b5ab4339" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/PublicStockOfferings" xlink:type="simple" xlink:href="xers-20201231.xsd#PublicStockOfferings"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/PublicStockOfferings" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_ReverseStockSplitandInitialPublicOfferingAbstract_67b9c3d8-4dcb-4169-83bf-96802e6a4d11" xlink:href="xers-20201231.xsd#xers_ReverseStockSplitandInitialPublicOfferingAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_bb3f9a24-ad47-4cdc-b81d-59564b93cfe7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquityNoteDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_ReverseStockSplitandInitialPublicOfferingAbstract_67b9c3d8-4dcb-4169-83bf-96802e6a4d11" xlink:to="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_bb3f9a24-ad47-4cdc-b81d-59564b93cfe7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/PublicStockOfferingsNarrativeDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#PublicStockOfferingsNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/PublicStockOfferingsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_ReverseStockSplitandInitialPublicOfferingAbstract_047fb616-ad32-481f-9f08-a5f8d619e25c" xlink:href="xers-20201231.xsd#xers_ReverseStockSplitandInitialPublicOfferingAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_16d3e24e-96b7-4f4f-96cf-6d2f3e59d785" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_ReverseStockSplitandInitialPublicOfferingAbstract_047fb616-ad32-481f-9f08-a5f8d619e25c" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_16d3e24e-96b7-4f4f-96cf-6d2f3e59d785" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_f10cfa55-e2e2-4d66-ad32-984bc61e048d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_ReverseStockSplitandInitialPublicOfferingAbstract_047fb616-ad32-481f-9f08-a5f8d619e25c" xlink:to="loc_us-gaap_CommonStockSharesIssued_f10cfa55-e2e2-4d66-ad32-984bc61e048d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesIssuedPricePerShare_c1a8493c-80a2-4ffb-96fb-d0f65de72dbd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SharesIssuedPricePerShare"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_ReverseStockSplitandInitialPublicOfferingAbstract_047fb616-ad32-481f-9f08-a5f8d619e25c" xlink:to="loc_us-gaap_SharesIssuedPricePerShare_c1a8493c-80a2-4ffb-96fb-d0f65de72dbd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Commonsharesissuedduetoexerciseofunderwriteroption_8fc0da2f-9017-475c-b263-d380b85b1216" xlink:href="xers-20201231.xsd#xers_Commonsharesissuedduetoexerciseofunderwriteroption"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_ReverseStockSplitandInitialPublicOfferingAbstract_047fb616-ad32-481f-9f08-a5f8d619e25c" xlink:to="loc_xers_Commonsharesissuedduetoexerciseofunderwriteroption_8fc0da2f-9017-475c-b263-d380b85b1216" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Netproceedsfromissuanceofpublicoffering_29768489-94ce-49df-89d0-564ceb2a3704" xlink:href="xers-20201231.xsd#xers_Netproceedsfromissuanceofpublicoffering"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_ReverseStockSplitandInitialPublicOfferingAbstract_047fb616-ad32-481f-9f08-a5f8d619e25c" xlink:to="loc_xers_Netproceedsfromissuanceofpublicoffering_29768489-94ce-49df-89d0-564ceb2a3704" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Aggregateamountofcommonstockavailabletosellunderashelfregistration_12726b21-e284-4c79-9af6-b576f34eef50" xlink:href="xers-20201231.xsd#xers_Aggregateamountofcommonstockavailabletosellunderashelfregistration"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_ReverseStockSplitandInitialPublicOfferingAbstract_047fb616-ad32-481f-9f08-a5f8d619e25c" xlink:to="loc_xers_Aggregateamountofcommonstockavailabletosellunderashelfregistration_12726b21-e284-4c79-9af6-b576f34eef50" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_AggregateamountofcommonstockavailabletosellunderatthemarketATMoffering_a644b033-d595-4659-8000-01538afce0d3" xlink:href="xers-20201231.xsd#xers_AggregateamountofcommonstockavailabletosellunderatthemarketATMoffering"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_ReverseStockSplitandInitialPublicOfferingAbstract_047fb616-ad32-481f-9f08-a5f8d619e25c" xlink:to="loc_xers_AggregateamountofcommonstockavailabletosellunderatthemarketATMoffering_a644b033-d595-4659-8000-01538afce0d3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_TotalCommonStockAndPreferredStockAuthorizedShares_7729e696-a758-4853-9556-cb23c4c4e5e2" xlink:href="xers-20201231.xsd#xers_TotalCommonStockAndPreferredStockAuthorizedShares"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_ReverseStockSplitandInitialPublicOfferingAbstract_047fb616-ad32-481f-9f08-a5f8d619e25c" xlink:to="loc_xers_TotalCommonStockAndPreferredStockAuthorizedShares_7729e696-a758-4853-9556-cb23c4c4e5e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_4d134a8c-5aac-4057-b477-ab18ee9bae22" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_ReverseStockSplitandInitialPublicOfferingAbstract_047fb616-ad32-481f-9f08-a5f8d619e25c" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_4d134a8c-5aac-4057-b477-ab18ee9bae22" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_8d930f72-22e2-4103-8319-a9c9570467b9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockSharesAuthorized"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_ReverseStockSplitandInitialPublicOfferingAbstract_047fb616-ad32-481f-9f08-a5f8d619e25c" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_8d930f72-22e2-4103-8319-a9c9570467b9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_1bb27782-b6ec-4b8e-8fe0-ff0cd4992260" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockParOrStatedValuePerShare"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_ReverseStockSplitandInitialPublicOfferingAbstract_047fb616-ad32-481f-9f08-a5f8d619e25c" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_1bb27782-b6ec-4b8e-8fe0-ff0cd4992260" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_RestrictedStockUnitsVestedAndSettledDuringPeriod_d93584ff-d3a0-453e-bacb-516536a9ebd0" xlink:href="xers-20201231.xsd#xers_RestrictedStockUnitsVestedAndSettledDuringPeriod"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_ReverseStockSplitandInitialPublicOfferingAbstract_047fb616-ad32-481f-9f08-a5f8d619e25c" xlink:to="loc_xers_RestrictedStockUnitsVestedAndSettledDuringPeriod_d93584ff-d3a0-453e-bacb-516536a9ebd0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation_65d568e3-90d2-4a88-81b0-2e04901760ea" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_ReverseStockSplitandInitialPublicOfferingAbstract_047fb616-ad32-481f-9f08-a5f8d619e25c" xlink:to="loc_us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation_65d568e3-90d2-4a88-81b0-2e04901760ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_StatutoryWithholdingTaxesOnVestingAndSettlementOfRSUs_eda14511-0abe-43d2-af7f-cdd515ff925b" xlink:href="xers-20201231.xsd#xers_StatutoryWithholdingTaxesOnVestingAndSettlementOfRSUs"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_ReverseStockSplitandInitialPublicOfferingAbstract_047fb616-ad32-481f-9f08-a5f8d619e25c" xlink:to="loc_xers_StatutoryWithholdingTaxesOnVestingAndSettlementOfRSUs_eda14511-0abe-43d2-af7f-cdd515ff925b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_PrincipalAmountOfConvertibleNotesConverted_e03889ea-6ba1-4580-b56a-b1e22d107679" xlink:href="xers-20201231.xsd#xers_PrincipalAmountOfConvertibleNotesConverted"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_ReverseStockSplitandInitialPublicOfferingAbstract_047fb616-ad32-481f-9f08-a5f8d619e25c" xlink:to="loc_xers_PrincipalAmountOfConvertibleNotesConverted_e03889ea-6ba1-4580-b56a-b1e22d107679" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_8ce4b046-7906-468c-bcc9-11fa6be42ca3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_ReverseStockSplitandInitialPublicOfferingAbstract_047fb616-ad32-481f-9f08-a5f8d619e25c" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_8ce4b046-7906-468c-bcc9-11fa6be42ca3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_InitialConversionRateForConvertibleNotes_be1a0fcd-e465-4f0b-899d-a314deee12c0" xlink:href="xers-20201231.xsd#xers_InitialConversionRateForConvertibleNotes"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_ReverseStockSplitandInitialPublicOfferingAbstract_047fb616-ad32-481f-9f08-a5f8d619e25c" xlink:to="loc_xers_InitialConversionRateForConvertibleNotes_be1a0fcd-e465-4f0b-899d-a314deee12c0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_PerPrincipalAmountOfConvertibleNotes_a8b19331-da03-44eb-9857-2114fac279a3" xlink:href="xers-20201231.xsd#xers_PerPrincipalAmountOfConvertibleNotes"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_ReverseStockSplitandInitialPublicOfferingAbstract_047fb616-ad32-481f-9f08-a5f8d619e25c" xlink:to="loc_xers_PerPrincipalAmountOfConvertibleNotes_a8b19331-da03-44eb-9857-2114fac279a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_PrincipalAmountOfConvertibleNotesConvertedPrivately_7094b4e4-16e6-49a4-afae-a860b27feeed" xlink:href="xers-20201231.xsd#xers_PrincipalAmountOfConvertibleNotesConvertedPrivately"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_ReverseStockSplitandInitialPublicOfferingAbstract_047fb616-ad32-481f-9f08-a5f8d619e25c" xlink:to="loc_xers_PrincipalAmountOfConvertibleNotesConvertedPrivately_7094b4e4-16e6-49a4-afae-a860b27feeed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_StockIssuedDuringPeriodSharesConversionOfConvertibleSecuritiesPrivatelyExchanged_f6858afd-04f7-4e02-9345-22c14d7fc827" xlink:href="xers-20201231.xsd#xers_StockIssuedDuringPeriodSharesConversionOfConvertibleSecuritiesPrivatelyExchanged"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_ReverseStockSplitandInitialPublicOfferingAbstract_047fb616-ad32-481f-9f08-a5f8d619e25c" xlink:to="loc_xers_StockIssuedDuringPeriodSharesConversionOfConvertibleSecuritiesPrivatelyExchanged_f6858afd-04f7-4e02-9345-22c14d7fc827" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/WarrantsNotes" xlink:type="simple" xlink:href="xers-20201231.xsd#WarrantsNotes"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/WarrantsNotes" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_WarrantsAbstract_f328b431-e155-4b53-8a56-0deff56ec1c5" xlink:href="xers-20201231.xsd#xers_WarrantsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesDisclosureTextBlock_8493a5b9-65ba-4d93-801b-b3f882af27b4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherLiabilitiesDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_WarrantsAbstract_f328b431-e155-4b53-8a56-0deff56ec1c5" xlink:to="loc_us-gaap_OtherLiabilitiesDisclosureTextBlock_8493a5b9-65ba-4d93-801b-b3f882af27b4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/WarrantsTables" xlink:type="simple" xlink:href="xers-20201231.xsd#WarrantsTables"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/WarrantsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_WarrantsAbstract_af505175-aad6-4336-8639-5503c22d369f" xlink:href="xers-20201231.xsd#xers_WarrantsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockholdersEquityNoteWarrantsOrRightsTextBlock_c592a909-a7d2-444e-8ee0-9c3b6100ff9c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfStockholdersEquityNoteWarrantsOrRightsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_WarrantsAbstract_af505175-aad6-4336-8639-5503c22d369f" xlink:to="loc_us-gaap_ScheduleOfStockholdersEquityNoteWarrantsOrRightsTextBlock_c592a909-a7d2-444e-8ee0-9c3b6100ff9c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/WarrantsScheduleofStockholdersEquityNoteWarrantsorRightsDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#WarrantsScheduleofStockholdersEquityNoteWarrantsorRightsDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/WarrantsScheduleofStockholdersEquityNoteWarrantsorRightsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_WarrantsAbstract_e3673190-a027-4f5a-bf95-6310cd63acbc" xlink:href="xers-20201231.xsd#xers_WarrantsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightTable_13b7cb96-eb60-432e-9ea0-0092b77610c9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ClassOfWarrantOrRightTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_WarrantsAbstract_e3673190-a027-4f5a-bf95-6310cd63acbc" xlink:to="loc_us-gaap_ClassOfWarrantOrRightTable_13b7cb96-eb60-432e-9ea0-0092b77610c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_5a925123-7775-4ddf-a4cc-0cf41c27e845" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_13b7cb96-eb60-432e-9ea0-0092b77610c9" xlink:to="loc_us-gaap_StatementClassOfStockAxis_5a925123-7775-4ddf-a4cc-0cf41c27e845" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_b786cc04-8d2f-478b-acdb-6bfc8c34c178" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_5a925123-7775-4ddf-a4cc-0cf41c27e845" xlink:to="loc_us-gaap_ClassOfStockDomain_b786cc04-8d2f-478b-acdb-6bfc8c34c178" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_A2014WarrantsMember_1e224ba7-e51a-4d46-82c7-934b42ddb9fb" xlink:href="xers-20201231.xsd#xers_A2014WarrantsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_b786cc04-8d2f-478b-acdb-6bfc8c34c178" xlink:to="loc_xers_A2014WarrantsMember_1e224ba7-e51a-4d46-82c7-934b42ddb9fb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_A2018TermAWarrantsMember_3447bdf8-6b5b-43b5-b3a3-30e127ad1855" xlink:href="xers-20201231.xsd#xers_A2018TermAWarrantsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_b786cc04-8d2f-478b-acdb-6bfc8c34c178" xlink:to="loc_xers_A2018TermAWarrantsMember_3447bdf8-6b5b-43b5-b3a3-30e127ad1855" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_A2018TermBWarrantsMember_85857f3c-3e75-4248-93dc-88d41ce52979" xlink:href="xers-20201231.xsd#xers_A2018TermBWarrantsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_b786cc04-8d2f-478b-acdb-6bfc8c34c178" xlink:to="loc_xers_A2018TermBWarrantsMember_85857f3c-3e75-4248-93dc-88d41ce52979" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightLineItems_c26dda8f-61a2-4d43-aa6d-5cb662816a11" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ClassOfWarrantOrRightLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_13b7cb96-eb60-432e-9ea0-0092b77610c9" xlink:to="loc_us-gaap_ClassOfWarrantOrRightLineItems_c26dda8f-61a2-4d43-aa6d-5cb662816a11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightOutstanding_6e012b25-4d3f-44c5-bc65-bb21a105c0f7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ClassOfWarrantOrRightOutstanding"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_c26dda8f-61a2-4d43-aa6d-5cb662816a11" xlink:to="loc_us-gaap_ClassOfWarrantOrRightOutstanding_6e012b25-4d3f-44c5-bc65-bb21a105c0f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_4801aa04-704d-4d7e-b9d5-24c6131c9242" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_c26dda8f-61a2-4d43-aa6d-5cb662816a11" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_4801aa04-704d-4d7e-b9d5-24c6131c9242" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/WarrantsNarrativeDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#WarrantsNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/WarrantsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_WarrantsAbstract_e17604a9-2b99-4f51-8221-6a5be7a9ccab" xlink:href="xers-20201231.xsd#xers_WarrantsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightTable_21932d25-9456-44f0-bbad-1e46caf01a68" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ClassOfWarrantOrRightTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_WarrantsAbstract_e17604a9-2b99-4f51-8221-6a5be7a9ccab" xlink:to="loc_us-gaap_ClassOfWarrantOrRightTable_21932d25-9456-44f0-bbad-1e46caf01a68" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_a8ba43c4-e73d-4bae-8df2-921b72715d4e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_21932d25-9456-44f0-bbad-1e46caf01a68" xlink:to="loc_us-gaap_StatementClassOfStockAxis_a8ba43c4-e73d-4bae-8df2-921b72715d4e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_f8295911-7f18-430e-8895-a7d7303cc96a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_a8ba43c4-e73d-4bae-8df2-921b72715d4e" xlink:to="loc_us-gaap_ClassOfStockDomain_f8295911-7f18-430e-8895-a7d7303cc96a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_A2018TermAWarrantsMember_34cb970a-9dfd-4e51-bd6a-1f62db580de3" xlink:href="xers-20201231.xsd#xers_A2018TermAWarrantsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_f8295911-7f18-430e-8895-a7d7303cc96a" xlink:to="loc_xers_A2018TermAWarrantsMember_34cb970a-9dfd-4e51-bd6a-1f62db580de3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_A2018TermBWarrantsMember_f5d14dc3-e59d-4b96-a916-6ccbe5464131" xlink:href="xers-20201231.xsd#xers_A2018TermBWarrantsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_f8295911-7f18-430e-8895-a7d7303cc96a" xlink:to="loc_xers_A2018TermBWarrantsMember_f5d14dc3-e59d-4b96-a916-6ccbe5464131" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_A2014WarrantsMember_7e2baa4f-2567-47de-b185-58fc419dc928" xlink:href="xers-20201231.xsd#xers_A2014WarrantsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_f8295911-7f18-430e-8895-a7d7303cc96a" xlink:to="loc_xers_A2014WarrantsMember_7e2baa4f-2567-47de-b185-58fc419dc928" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightLineItems_fdacde8d-7404-4939-a24f-0e20bf9bb8b7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ClassOfWarrantOrRightLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_21932d25-9456-44f0-bbad-1e46caf01a68" xlink:to="loc_us-gaap_ClassOfWarrantOrRightLineItems_fdacde8d-7404-4939-a24f-0e20bf9bb8b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Preferredstockandwarrantsissuedduringtheperiodshares_8041c8f7-47d8-465e-ad44-67e4e5a299a0" xlink:href="xers-20201231.xsd#xers_Preferredstockandwarrantsissuedduringtheperiodshares"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_fdacde8d-7404-4939-a24f-0e20bf9bb8b7" xlink:to="loc_xers_Preferredstockandwarrantsissuedduringtheperiodshares_8041c8f7-47d8-465e-ad44-67e4e5a299a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_9bdeda27-e2c1-4751-9701-e472bd4a4dfc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_fdacde8d-7404-4939-a24f-0e20bf9bb8b7" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_9bdeda27-e2c1-4751-9701-e472bd4a4dfc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Classofwarrantsexercised_e49dbfb9-e362-459a-970b-ee47365b86ae" xlink:href="xers-20201231.xsd#xers_Classofwarrantsexercised"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_fdacde8d-7404-4939-a24f-0e20bf9bb8b7" xlink:to="loc_xers_Classofwarrantsexercised_e49dbfb9-e362-459a-970b-ee47365b86ae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightOutstanding_b71bfa67-e2b3-4eeb-b9d8-99ec3a8242ba" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ClassOfWarrantOrRightOutstanding"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_fdacde8d-7404-4939-a24f-0e20bf9bb8b7" xlink:to="loc_us-gaap_ClassOfWarrantOrRightOutstanding_b71bfa67-e2b3-4eeb-b9d8-99ec3a8242ba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_6e46130f-3e75-4d4c-b82a-0676256afddc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueAdjustmentOfWarrants"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_fdacde8d-7404-4939-a24f-0e20bf9bb8b7" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_6e46130f-3e75-4d4c-b82a-0676256afddc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_ClassOfWarrantsExpired_0b7ed354-7011-4d9f-acfd-1f1962c76231" xlink:href="xers-20201231.xsd#xers_ClassOfWarrantsExpired"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_fdacde8d-7404-4939-a24f-0e20bf9bb8b7" xlink:to="loc_xers_ClassOfWarrantsExpired_0b7ed354-7011-4d9f-acfd-1f1962c76231" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/CommitmentsandContingencies" xlink:type="simple" xlink:href="xers-20201231.xsd#CommitmentsandContingencies"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/CommitmentsandContingencies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_07ed6aaa-b08d-4afe-a9fd-3df468b1e3eb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_d4927c73-967f-4ba1-8914-47b3002766a5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_07ed6aaa-b08d-4afe-a9fd-3df468b1e3eb" xlink:to="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_d4927c73-967f-4ba1-8914-47b3002766a5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/CommitmentsandContingenciesFutureMinimumLeasePaymentsTables" xlink:type="simple" xlink:href="xers-20201231.xsd#CommitmentsandContingenciesFutureMinimumLeasePaymentsTables"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/CommitmentsandContingenciesFutureMinimumLeasePaymentsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_1185397a-b4f9-4552-9f9c-ae7af75e4c04" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFutureMinimumRentalPaymentsForOperatingLeasesTableTextBlock_fff1d81e-33f6-4f49-ad1c-3a0d1b89e398" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfFutureMinimumRentalPaymentsForOperatingLeasesTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_1185397a-b4f9-4552-9f9c-ae7af75e4c04" xlink:to="loc_us-gaap_ScheduleOfFutureMinimumRentalPaymentsForOperatingLeasesTableTextBlock_fff1d81e-33f6-4f49-ad1c-3a0d1b89e398" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/CommitmentsandContingenciesNarrativeDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#CommitmentsandContingenciesNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/CommitmentsandContingenciesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_0c3e201c-d715-4cdf-bde4-6d33a868df66" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_9387636e-5c98-41e4-a8ad-9ff9b0198ba3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_0c3e201c-d715-4cdf-bde4-6d33a868df66" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_9387636e-5c98-41e4-a8ad-9ff9b0198ba3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_649fbde0-810f-44de-b598-666b73c71f94" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_0c3e201c-d715-4cdf-bde4-6d33a868df66" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_649fbde0-810f-44de-b598-666b73c71f94" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_50c50e67-1338-4ded-bb6e-38d1afc1ef76" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_0c3e201c-d715-4cdf-bde4-6d33a868df66" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_50c50e67-1338-4ded-bb6e-38d1afc1ef76" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_5f0a2246-5a36-4b3c-abf5-eca05290d335" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_0c3e201c-d715-4cdf-bde4-6d33a868df66" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_5f0a2246-5a36-4b3c-abf5-eca05290d335" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_7243eb75-6481-418a-8f1f-9e0553a93964" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_0c3e201c-d715-4cdf-bde4-6d33a868df66" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_7243eb75-6481-418a-8f1f-9e0553a93964" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter_5a2052ff-8fac-48d2-97f5-e4e0ee9fd915" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_0c3e201c-d715-4cdf-bde4-6d33a868df66" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter_5a2052ff-8fac-48d2-97f5-e4e0ee9fd915" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_5bd78cbd-a227-4678-8655-cf184e50e032" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDue"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_0c3e201c-d715-4cdf-bde4-6d33a868df66" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_5bd78cbd-a227-4678-8655-cf184e50e032" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseAndRentalExpense_2676171b-10dd-48bc-88ce-f78a30f001bf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LeaseAndRentalExpense"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_0c3e201c-d715-4cdf-bde4-6d33a868df66" xlink:to="loc_us-gaap_LeaseAndRentalExpense_2676171b-10dd-48bc-88ce-f78a30f001bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LettersOfCreditOutstandingAmount_98f5de24-7b80-41f3-8cde-710c1b6c0efd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LettersOfCreditOutstandingAmount"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_0c3e201c-d715-4cdf-bde4-6d33a868df66" xlink:to="loc_us-gaap_LettersOfCreditOutstandingAmount_98f5de24-7b80-41f3-8cde-710c1b6c0efd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitmentsTable_e84e006f-6d6e-43ae-b692-d5b4509129a8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherCommitmentsTable"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_0c3e201c-d715-4cdf-bde4-6d33a868df66" xlink:to="loc_us-gaap_OtherCommitmentsTable_e84e006f-6d6e-43ae-b692-d5b4509129a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermAxis_d00a1445-0b78-4a3e-8424-004dd1e0b0f9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LeaseContractualTermAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsTable_e84e006f-6d6e-43ae-b692-d5b4509129a8" xlink:to="loc_us-gaap_LeaseContractualTermAxis_d00a1445-0b78-4a3e-8424-004dd1e0b0f9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermDomain_daad7c68-e106-49c5-b803-f036e2ae43b2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LeaseContractualTermDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeaseContractualTermAxis_d00a1445-0b78-4a3e-8424-004dd1e0b0f9" xlink:to="loc_us-gaap_LeaseContractualTermDomain_daad7c68-e106-49c5-b803-f036e2ae43b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_ChicagoFultonMarketMember_7afc0407-6c29-435e-8e0a-302f04193b12" xlink:href="xers-20201231.xsd#xers_ChicagoFultonMarketMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeaseContractualTermDomain_daad7c68-e106-49c5-b803-f036e2ae43b2" xlink:to="loc_xers_ChicagoFultonMarketMember_7afc0407-6c29-435e-8e0a-302f04193b12" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitmentsLineItems_8f0b0d46-85b3-46bf-a349-3fe2a4a37755" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherCommitmentsLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsTable_e84e006f-6d6e-43ae-b692-d5b4509129a8" xlink:to="loc_us-gaap_OtherCommitmentsLineItems_8f0b0d46-85b3-46bf-a349-3fe2a4a37755" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_0b309061-55be-4c6b-bd32-6bef626a8822" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsLineItems_8f0b0d46-85b3-46bf-a349-3fe2a4a37755" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_0b309061-55be-4c6b-bd32-6bef626a8822" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_2b602eeb-bbc3-4eda-8657-a08c9a48c062" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsLineItems_8f0b0d46-85b3-46bf-a349-3fe2a4a37755" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_2b602eeb-bbc3-4eda-8657-a08c9a48c062" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_295ee23a-07e9-4e48-9b8f-2ef71270e6d1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsLineItems_8f0b0d46-85b3-46bf-a349-3fe2a4a37755" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_295ee23a-07e9-4e48-9b8f-2ef71270e6d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_a47c4556-cd3e-42af-a0a5-bcc87c94997e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsLineItems_8f0b0d46-85b3-46bf-a349-3fe2a4a37755" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_a47c4556-cd3e-42af-a0a5-bcc87c94997e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_a88be623-53c9-4a88-9511-baf0d1b621a6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsLineItems_8f0b0d46-85b3-46bf-a349-3fe2a4a37755" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_a88be623-53c9-4a88-9511-baf0d1b621a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter_80a9bde6-b2b2-41b7-9d14-e13a2eee5018" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsLineItems_8f0b0d46-85b3-46bf-a349-3fe2a4a37755" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter_80a9bde6-b2b2-41b7-9d14-e13a2eee5018" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/RestructuringandRelatedActivities" xlink:type="simple" xlink:href="xers-20201231.xsd#RestructuringandRelatedActivities"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/RestructuringandRelatedActivities" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_828fe4ba-53e8-456a-a868-13926d7c0fde" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringAndRelatedActivitiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedActivitiesDisclosureTextBlock_b2bce476-7857-4117-bc10-5281e8ff6b8f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringAndRelatedActivitiesDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_828fe4ba-53e8-456a-a868-13926d7c0fde" xlink:to="loc_us-gaap_RestructuringAndRelatedActivitiesDisclosureTextBlock_b2bce476-7857-4117-bc10-5281e8ff6b8f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/RestructuringandRelatedActivitiesTables" xlink:type="simple" xlink:href="xers-20201231.xsd#RestructuringandRelatedActivitiesTables"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/RestructuringandRelatedActivitiesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_6d779dfc-7c9b-4509-91f7-c736588211ca" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringAndRelatedActivitiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTextBlock_d6c9cff0-b930-4c89-bab3-a82fbc719d96" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_6d779dfc-7c9b-4509-91f7-c736588211ca" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTextBlock_d6c9cff0-b930-4c89-bab3-a82fbc719d96" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/RestructuringandRelatedActivitiesDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#RestructuringandRelatedActivitiesDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/RestructuringandRelatedActivitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_e83693e7-1560-4230-8b3c-3611f3520d09" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringAndRelatedActivitiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedCostExpectedCost1_92ec8f86-a2d4-420e-881d-83a9bff6d5d9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringAndRelatedCostExpectedCost1"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_e83693e7-1560-4230-8b3c-3611f3520d09" xlink:to="loc_us-gaap_RestructuringAndRelatedCostExpectedCost1_92ec8f86-a2d4-420e-881d-83a9bff6d5d9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_bf53275a-1263-4701-be4b-0859371dd3c2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringCharges"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_e83693e7-1560-4230-8b3c-3611f3520d09" xlink:to="loc_us-gaap_RestructuringCharges_bf53275a-1263-4701-be4b-0859371dd3c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_1a1516d3-b8be-4592-8a81-cd6eec711a24" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringAndRelatedActivitiesAbstract_e83693e7-1560-4230-8b3c-3611f3520d09" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_1a1516d3-b8be-4592-8a81-cd6eec711a24" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveAxis_6f39ae3b-1511-4938-80c7-1a66f31932ca" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringCostAndReserveAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_1a1516d3-b8be-4592-8a81-cd6eec711a24" xlink:to="loc_us-gaap_RestructuringCostAndReserveAxis_6f39ae3b-1511-4938-80c7-1a66f31932ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_9540b88b-e42e-474f-989b-8f7eb526919f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_6f39ae3b-1511-4938-80c7-1a66f31932ca" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_9540b88b-e42e-474f-989b-8f7eb526919f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeSeveranceMember_c88bad5c-7482-4b49-b509-785e06abe6db" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeSeveranceMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_9540b88b-e42e-474f-989b-8f7eb526919f" xlink:to="loc_us-gaap_EmployeeSeveranceMember_c88bad5c-7482-4b49-b509-785e06abe6db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherRestructuringMember_32234708-dc93-4de1-94a0-1898c9324f69" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherRestructuringMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_9540b88b-e42e-474f-989b-8f7eb526919f" xlink:to="loc_us-gaap_OtherRestructuringMember_32234708-dc93-4de1-94a0-1898c9324f69" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_b7e8b4d5-3916-485f-ab7f-79ba67a69394" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_1a1516d3-b8be-4592-8a81-cd6eec711a24" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_b7e8b4d5-3916-485f-ab7f-79ba67a69394" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_480c004b-001e-41e5-9f7e-f12b6c36f2ce" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_b7e8b4d5-3916-485f-ab7f-79ba67a69394" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_480c004b-001e-41e5-9f7e-f12b6c36f2ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_80834109-ef6b-49aa-838e-d947f5354786" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_480c004b-001e-41e5-9f7e-f12b6c36f2ce" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_80834109-ef6b-49aa-838e-d947f5354786" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_5079caf2-290b-45c1-967a-963541e40d9a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_480c004b-001e-41e5-9f7e-f12b6c36f2ce" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_5079caf2-290b-45c1-967a-963541e40d9a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfSalesMember_37af71d4-d4fc-4b64-8f01-25c7e6384397" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CostOfSalesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_480c004b-001e-41e5-9f7e-f12b6c36f2ce" xlink:to="loc_us-gaap_CostOfSalesMember_37af71d4-d4fc-4b64-8f01-25c7e6384397" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_74a7d483-381c-44c1-8fb5-22250647ded6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_1a1516d3-b8be-4592-8a81-cd6eec711a24" xlink:to="loc_us-gaap_RestructuringCostAndReserveLineItems_74a7d483-381c-44c1-8fb5-22250647ded6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_5630d835-16fa-450f-aa1e-8a08abe420e3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringCharges"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_74a7d483-381c-44c1-8fb5-22250647ded6" xlink:to="loc_us-gaap_RestructuringCharges_5630d835-16fa-450f-aa1e-8a08abe420e3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRestructuring_0beb966b-daf0-44dd-ba4e-c9af0c72f78e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsForRestructuring"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_74a7d483-381c-44c1-8fb5-22250647ded6" xlink:to="loc_us-gaap_PaymentsForRestructuring_0beb966b-daf0-44dd-ba4e-c9af0c72f78e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveCurrent_47ad59fd-429a-498b-9a4a-1ebe26cfc3c3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestructuringReserveCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_74a7d483-381c-44c1-8fb5-22250647ded6" xlink:to="loc_us-gaap_RestructuringReserveCurrent_47ad59fd-429a-498b-9a4a-1ebe26cfc3c3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/StockCompensationPlanNotes" xlink:type="simple" xlink:href="xers-20201231.xsd#StockCompensationPlanNotes"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/StockCompensationPlanNotes" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_1cc942b9-9dbf-4b62-9511-056ec087cca0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_8c93df3a-7da8-49dd-af97-38677319c44d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_1cc942b9-9dbf-4b62-9511-056ec087cca0" xlink:to="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_8c93df3a-7da8-49dd-af97-38677319c44d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/StockCompensationPlanTables" xlink:type="simple" xlink:href="xers-20201231.xsd#StockCompensationPlanTables"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/StockCompensationPlanTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_dfd08239-2a0d-4acb-8f90-2c592b70f1d0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8fe7db38-2937-4910-9f52-fa2b07fce057" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_dfd08239-2a0d-4acb-8f90-2c592b70f1d0" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8fe7db38-2937-4910-9f52-fa2b07fce057" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_1c9a6f34-111e-4240-bf0f-5ccc9ad8799b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8fe7db38-2937-4910-9f52-fa2b07fce057" xlink:to="loc_us-gaap_AwardTypeAxis_1c9a6f34-111e-4240-bf0f-5ccc9ad8799b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_ef0d726c-fe7a-4e83-8d75-11f325b8daa1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_1c9a6f34-111e-4240-bf0f-5ccc9ad8799b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_ef0d726c-fe7a-4e83-8d75-11f325b8daa1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_2a1afcc4-884a-4206-8929-9603198f3e23" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_ef0d726c-fe7a-4e83-8d75-11f325b8daa1" xlink:to="loc_us-gaap_EmployeeStockOptionMember_2a1afcc4-884a-4206-8929-9603198f3e23" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_2ef5df55-f744-41da-a0bd-8c53bceea592" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_ef0d726c-fe7a-4e83-8d75-11f325b8daa1" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_2ef5df55-f744-41da-a0bd-8c53bceea592" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_038fcce0-5497-4db7-b557-d86ff12a0400" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8fe7db38-2937-4910-9f52-fa2b07fce057" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_038fcce0-5497-4db7-b557-d86ff12a0400" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock_e961ae40-7b4f-4298-b1c8-5703ef511cdc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_038fcce0-5497-4db7-b557-d86ff12a0400" xlink:to="loc_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock_e961ae40-7b4f-4298-b1c8-5703ef511cdc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock_842199cb-a842-4024-b333-c482ff02e29b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_038fcce0-5497-4db7-b557-d86ff12a0400" xlink:to="loc_us-gaap_ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock_842199cb-a842-4024-b333-c482ff02e29b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_SharebasedCompensationArrangementbySharebasedPaymentAwardFairValueAssumptionsMethodUsedTableTextBlock_cedb5131-7fa0-4407-a62e-9473374181d8" xlink:href="xers-20201231.xsd#xers_SharebasedCompensationArrangementbySharebasedPaymentAwardFairValueAssumptionsMethodUsedTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_038fcce0-5497-4db7-b557-d86ff12a0400" xlink:to="loc_xers_SharebasedCompensationArrangementbySharebasedPaymentAwardFairValueAssumptionsMethodUsedTableTextBlock_cedb5131-7fa0-4407-a62e-9473374181d8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationActivityTableTextBlock_908bbb95-9848-4a70-89b8-4a0c60c5e372" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationActivityTableTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_038fcce0-5497-4db7-b557-d86ff12a0400" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationActivityTableTextBlock_908bbb95-9848-4a70-89b8-4a0c60c5e372" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock_865d13eb-c75c-40be-b033-2ccd9bedb63d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_038fcce0-5497-4db7-b557-d86ff12a0400" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock_865d13eb-c75c-40be-b033-2ccd9bedb63d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/StockCompensationPlanSharebasedCompensationArrangementbySharebasedPaymentAwardFairValueAssumptionsMethodUsedDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#StockCompensationPlanSharebasedCompensationArrangementbySharebasedPaymentAwardFairValueAssumptionsMethodUsedDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/StockCompensationPlanSharebasedCompensationArrangementbySharebasedPaymentAwardFairValueAssumptionsMethodUsedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_SharebasedCompensationArrangementbySharebasedPaymentAwardFairValueAssumptionsMethodUsedAbstract_51b58c45-d882-4da0-87e1-c8c5816e547f" xlink:href="xers-20201231.xsd#xers_SharebasedCompensationArrangementbySharebasedPaymentAwardFairValueAssumptionsMethodUsedAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_053f2639-a505-436f-ac9b-44727f0e9e87" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_SharebasedCompensationArrangementbySharebasedPaymentAwardFairValueAssumptionsMethodUsedAbstract_51b58c45-d882-4da0-87e1-c8c5816e547f" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_053f2639-a505-436f-ac9b-44727f0e9e87" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_b5f61374-5a8a-4583-b129-55c78f23ba75" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_053f2639-a505-436f-ac9b-44727f0e9e87" xlink:to="loc_us-gaap_AwardTypeAxis_b5f61374-5a8a-4583-b129-55c78f23ba75" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_743e1577-3ac4-4891-937a-35808b0b95cb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_b5f61374-5a8a-4583-b129-55c78f23ba75" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_743e1577-3ac4-4891-937a-35808b0b95cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_9aa68d30-65a2-42c7-9537-e0a587f12da1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_743e1577-3ac4-4891-937a-35808b0b95cb" xlink:to="loc_us-gaap_EmployeeStockOptionMember_9aa68d30-65a2-42c7-9537-e0a587f12da1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_114dd7e4-c15d-48ea-8c96-5483473b3bc3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_743e1577-3ac4-4891-937a-35808b0b95cb" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_114dd7e4-c15d-48ea-8c96-5483473b3bc3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_f8919f4c-330f-437e-bb1a-dc564b962690" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_053f2639-a505-436f-ac9b-44727f0e9e87" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_f8919f4c-330f-437e-bb1a-dc564b962690" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_c52abeaf-a15f-4927-8e03-abd8b212dea5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_f8919f4c-330f-437e-bb1a-dc564b962690" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_c52abeaf-a15f-4927-8e03-abd8b212dea5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_81ee734a-e0ae-4304-8882-bd75d20ac807" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_f8919f4c-330f-437e-bb1a-dc564b962690" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_81ee734a-e0ae-4304-8882-bd75d20ac807" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_c4bc6558-d88e-46be-80af-2a649ad61650" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_f8919f4c-330f-437e-bb1a-dc564b962690" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_c4bc6558-d88e-46be-80af-2a649ad61650" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_3a0fc611-0e81-4f94-8e29-b8d200eff133" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_f8919f4c-330f-437e-bb1a-dc564b962690" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_3a0fc611-0e81-4f94-8e29-b8d200eff133" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/StockCompensationPlanEmployeeStockAwardActivityDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#StockCompensationPlanEmployeeStockAwardActivityDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/StockCompensationPlanEmployeeStockAwardActivityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_0dcb501e-25ac-439e-aa6e-86ca45e81863" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_546a6dee-e6d6-4356-a4aa-e80065314f37" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_0dcb501e-25ac-439e-aa6e-86ca45e81863" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_546a6dee-e6d6-4356-a4aa-e80065314f37" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_7d0eb621-b903-4bdc-a188-7ac4a8f95641" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_546a6dee-e6d6-4356-a4aa-e80065314f37" xlink:to="loc_us-gaap_AwardTypeAxis_7d0eb621-b903-4bdc-a188-7ac4a8f95641" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_aef2ecb3-a6fe-48f2-9c19-ac8e8f874ce3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_7d0eb621-b903-4bdc-a188-7ac4a8f95641" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_aef2ecb3-a6fe-48f2-9c19-ac8e8f874ce3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_58b3aecc-ab28-40ff-b151-53ac376e3502" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_aef2ecb3-a6fe-48f2-9c19-ac8e8f874ce3" xlink:to="loc_us-gaap_EmployeeStockOptionMember_58b3aecc-ab28-40ff-b151-53ac376e3502" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_NonemployeestockoptionsMember_150f656f-d58a-4be4-a3f4-7ca5454b8ea3" xlink:href="xers-20201231.xsd#xers_NonemployeestockoptionsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_aef2ecb3-a6fe-48f2-9c19-ac8e8f874ce3" xlink:to="loc_xers_NonemployeestockoptionsMember_150f656f-d58a-4be4-a3f4-7ca5454b8ea3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ed06038d-490b-4d41-bdd9-8d2f24cf7463" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_546a6dee-e6d6-4356-a4aa-e80065314f37" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ed06038d-490b-4d41-bdd9-8d2f24cf7463" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_ce4699de-d005-4844-8f17-c03a2dd9c59a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ed06038d-490b-4d41-bdd9-8d2f24cf7463" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_ce4699de-d005-4844-8f17-c03a2dd9c59a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_8327604d-c34e-42df-8ec9-db872cf36240" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ed06038d-490b-4d41-bdd9-8d2f24cf7463" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_8327604d-c34e-42df-8ec9-db872cf36240" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_b07b6f47-9994-4a57-bd54-9034e8de1904" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ed06038d-490b-4d41-bdd9-8d2f24cf7463" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_b07b6f47-9994-4a57-bd54-9034e8de1904" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_f511fe07-b2f5-40d9-ac77-3647ed18e715" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ed06038d-490b-4d41-bdd9-8d2f24cf7463" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_f511fe07-b2f5-40d9-ac77-3647ed18e715" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_e31bddd0-100f-404e-b514-ddf8cc96e4a9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ed06038d-490b-4d41-bdd9-8d2f24cf7463" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_e31bddd0-100f-404e-b514-ddf8cc96e4a9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_b23f3cb6-fc88-46d3-a52f-9b4b22de1bd7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ed06038d-490b-4d41-bdd9-8d2f24cf7463" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_b23f3cb6-fc88-46d3-a52f-9b4b22de1bd7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodUponOptionExchangeWeightedAverageExercisePrice_63cfb86e-9cfb-4d62-a135-e7bb00723dda" xlink:href="xers-20201231.xsd#xers_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodUponOptionExchangeWeightedAverageExercisePrice"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ed06038d-490b-4d41-bdd9-8d2f24cf7463" xlink:to="loc_xers_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodUponOptionExchangeWeightedAverageExercisePrice_63cfb86e-9cfb-4d62-a135-e7bb00723dda" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriodUponOptionExchange_8ddad7ec-aa7a-45f7-8071-63e4a50a991c" xlink:href="xers-20201231.xsd#xers_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriodUponOptionExchange"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ed06038d-490b-4d41-bdd9-8d2f24cf7463" xlink:to="loc_xers_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriodUponOptionExchange_8ddad7ec-aa7a-45f7-8071-63e4a50a991c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsCancelledUponOptionExchangeInPeriodWeightedAverageExercisePrice_5af9d542-b2df-48dc-8393-c0cfc65931ec" xlink:href="xers-20201231.xsd#xers_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsCancelledUponOptionExchangeInPeriodWeightedAverageExercisePrice"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ed06038d-490b-4d41-bdd9-8d2f24cf7463" xlink:to="loc_xers_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsCancelledUponOptionExchangeInPeriodWeightedAverageExercisePrice_5af9d542-b2df-48dc-8393-c0cfc65931ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsCancelledUponOptionExchange_875c0327-dc85-4046-a863-303df5321133" xlink:href="xers-20201231.xsd#xers_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsCancelledUponOptionExchange"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ed06038d-490b-4d41-bdd9-8d2f24cf7463" xlink:to="loc_xers_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsCancelledUponOptionExchange_875c0327-dc85-4046-a863-303df5321133" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_863da287-bdaf-4ef0-9cae-c0fb1d3f4ba5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ed06038d-490b-4d41-bdd9-8d2f24cf7463" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_863da287-bdaf-4ef0-9cae-c0fb1d3f4ba5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_4cafaf17-3b3e-4924-9a6e-9cefc0d567df" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ed06038d-490b-4d41-bdd9-8d2f24cf7463" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_4cafaf17-3b3e-4924-9a6e-9cefc0d567df" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedOptionsForfeitedNumberOfShares_3bf28d15-ae07-4f81-94eb-e460636ab730" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedOptionsForfeitedNumberOfShares"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ed06038d-490b-4d41-bdd9-8d2f24cf7463" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedOptionsForfeitedNumberOfShares_3bf28d15-ae07-4f81-94eb-e460636ab730" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodWeightedAverageExercisePrice_c78eab0d-f407-4ef7-b0b9-a1f3350f5754" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodWeightedAverageExercisePrice"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ed06038d-490b-4d41-bdd9-8d2f24cf7463" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodWeightedAverageExercisePrice_c78eab0d-f407-4ef7-b0b9-a1f3350f5754" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod_56312ba9-40d8-48f8-99d6-f91726746ed8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ed06038d-490b-4d41-bdd9-8d2f24cf7463" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod_56312ba9-40d8-48f8-99d6-f91726746ed8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice_7d192d02-f21c-42d8-b104-4f6b3469bcc9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ed06038d-490b-4d41-bdd9-8d2f24cf7463" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice_7d192d02-f21c-42d8-b104-4f6b3469bcc9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_363e233b-112b-4794-9422-b9f044e629f6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ed06038d-490b-4d41-bdd9-8d2f24cf7463" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_363e233b-112b-4794-9422-b9f044e629f6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_b985674f-83fa-48c2-8039-18c5782d6e9b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ed06038d-490b-4d41-bdd9-8d2f24cf7463" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_b985674f-83fa-48c2-8039-18c5782d6e9b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_4d0a6f08-2b6e-4bf5-8110-51dfea0466fe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ed06038d-490b-4d41-bdd9-8d2f24cf7463" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_4d0a6f08-2b6e-4bf5-8110-51dfea0466fe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber_47cbec67-11f6-405c-ae8b-8a6b66b43f13" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ed06038d-490b-4d41-bdd9-8d2f24cf7463" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber_47cbec67-11f6-405c-ae8b-8a6b66b43f13" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice_202c89f1-bdea-4dd3-bbac-de7c1e39f1d1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ed06038d-490b-4d41-bdd9-8d2f24cf7463" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice_202c89f1-bdea-4dd3-bbac-de7c1e39f1d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1_2e71129a-f0c0-414f-bd56-dfec9978ca13" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_ed06038d-490b-4d41-bdd9-8d2f24cf7463" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1_2e71129a-f0c0-414f-bd56-dfec9978ca13" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/StockCompensationPlanNarrativeDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#StockCompensationPlanNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/StockCompensationPlanNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_StockCompensationAbstract_033ade2a-c7fe-40c7-8762-57bacf986cf6" xlink:href="xers-20201231.xsd#xers_StockCompensationAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_1d5605e1-da4a-4dc8-9fcf-d86f78120311" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_StockCompensationAbstract_033ade2a-c7fe-40c7-8762-57bacf986cf6" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_1d5605e1-da4a-4dc8-9fcf-d86f78120311" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOwnershipPlanESOPDisclosuresByPlanAxis_706704fd-3e68-46e7-bd91-814fa390d010" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeStockOwnershipPlanESOPDisclosuresByPlanAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_1d5605e1-da4a-4dc8-9fcf-d86f78120311" xlink:to="loc_us-gaap_EmployeeStockOwnershipPlanESOPDisclosuresByPlanAxis_706704fd-3e68-46e7-bd91-814fa390d010" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOwnershipPlanESOPPlanDomain_ea8bb1d0-8de9-4fa9-a7ff-4e6934b0d85f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeStockOwnershipPlanESOPPlanDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeStockOwnershipPlanESOPDisclosuresByPlanAxis_706704fd-3e68-46e7-bd91-814fa390d010" xlink:to="loc_us-gaap_EmployeeStockOwnershipPlanESOPPlanDomain_ea8bb1d0-8de9-4fa9-a7ff-4e6934b0d85f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_A2011StockOptionIssuancePlanMember_af5ef1ba-de8b-46d0-9e2f-84d26c7f90a4" xlink:href="xers-20201231.xsd#xers_A2011StockOptionIssuancePlanMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeStockOwnershipPlanESOPPlanDomain_ea8bb1d0-8de9-4fa9-a7ff-4e6934b0d85f" xlink:to="loc_xers_A2011StockOptionIssuancePlanMember_af5ef1ba-de8b-46d0-9e2f-84d26c7f90a4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_A2018StockOptionandIncentivePlanMember_bc71a71c-a12c-409b-96b8-20e632e183ab" xlink:href="xers-20201231.xsd#xers_A2018StockOptionandIncentivePlanMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeStockOwnershipPlanESOPPlanDomain_ea8bb1d0-8de9-4fa9-a7ff-4e6934b0d85f" xlink:to="loc_xers_A2018StockOptionandIncentivePlanMember_bc71a71c-a12c-409b-96b8-20e632e183ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockMember_4e9624af-bc17-4ff7-b990-c84bdbd83ceb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeStockMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeStockOwnershipPlanESOPPlanDomain_ea8bb1d0-8de9-4fa9-a7ff-4e6934b0d85f" xlink:to="loc_us-gaap_EmployeeStockMember_4e9624af-bc17-4ff7-b990-c84bdbd83ceb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_EquityInducementPlanMember_3b1e3428-3d46-40c2-be44-bf8c0602beed" xlink:href="xers-20201231.xsd#xers_EquityInducementPlanMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeStockOwnershipPlanESOPPlanDomain_ea8bb1d0-8de9-4fa9-a7ff-4e6934b0d85f" xlink:to="loc_xers_EquityInducementPlanMember_3b1e3428-3d46-40c2-be44-bf8c0602beed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_61f35eb7-9ce8-4234-bd01-977d863d59b0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_1d5605e1-da4a-4dc8-9fcf-d86f78120311" xlink:to="loc_us-gaap_AwardTypeAxis_61f35eb7-9ce8-4234-bd01-977d863d59b0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_64e84b3d-45d3-4f51-9769-acba5361cd2b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_61f35eb7-9ce8-4234-bd01-977d863d59b0" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_64e84b3d-45d3-4f51-9769-acba5361cd2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_0c7bb831-1685-4641-81c1-3ba5302d24aa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_64e84b3d-45d3-4f51-9769-acba5361cd2b" xlink:to="loc_us-gaap_EmployeeStockOptionMember_0c7bb831-1685-4641-81c1-3ba5302d24aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_NonemployeestockoptionsMember_c5b579ea-e5b6-40ee-af05-6d3aa7b33925" xlink:href="xers-20201231.xsd#xers_NonemployeestockoptionsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_64e84b3d-45d3-4f51-9769-acba5361cd2b" xlink:to="loc_xers_NonemployeestockoptionsMember_c5b579ea-e5b6-40ee-af05-6d3aa7b33925" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_ExchangeOfferMember_10220d23-5c7f-4a26-bdca-6a2239640c3a" xlink:href="xers-20201231.xsd#xers_ExchangeOfferMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_64e84b3d-45d3-4f51-9769-acba5361cd2b" xlink:to="loc_xers_ExchangeOfferMember_10220d23-5c7f-4a26-bdca-6a2239640c3a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_ad63e271-2d78-4e15-a522-377e03e0f359" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_1d5605e1-da4a-4dc8-9fcf-d86f78120311" xlink:to="loc_srt_RangeAxis_ad63e271-2d78-4e15-a522-377e03e0f359" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_98dc8268-f99b-4889-b5d3-e7b9215b6cb2" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_ad63e271-2d78-4e15-a522-377e03e0f359" xlink:to="loc_srt_RangeMember_98dc8268-f99b-4889-b5d3-e7b9215b6cb2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_b8e88471-b474-41e5-b7f0-ecce23560e08" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_98dc8268-f99b-4889-b5d3-e7b9215b6cb2" xlink:to="loc_srt_MinimumMember_b8e88471-b474-41e5-b7f0-ecce23560e08" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_55352725-d858-4191-92a3-88005fafe01c" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_98dc8268-f99b-4889-b5d3-e7b9215b6cb2" xlink:to="loc_srt_MaximumMember_55352725-d858-4191-92a3-88005fafe01c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c42469-7123-4f87-ab3d-7cb3472b3ad9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_1d5605e1-da4a-4dc8-9fcf-d86f78120311" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c42469-7123-4f87-ab3d-7cb3472b3ad9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_d0aa4c20-c28a-479a-b6fe-60b2b38f2902" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c42469-7123-4f87-ab3d-7cb3472b3ad9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_d0aa4c20-c28a-479a-b6fe-60b2b38f2902" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Maximumemployeepayrolldeductionpercentage_1ef4fa82-312c-4fe7-88e9-46dc9e7773bc" xlink:href="xers-20201231.xsd#xers_Maximumemployeepayrolldeductionpercentage"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c42469-7123-4f87-ab3d-7cb3472b3ad9" xlink:to="loc_xers_Maximumemployeepayrolldeductionpercentage_1ef4fa82-312c-4fe7-88e9-46dc9e7773bc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Commonstockvaluetaxlimitonemployeestockpurchaseplan_308da090-ce17-41ea-a161-372744ecd8b9" xlink:href="xers-20201231.xsd#xers_Commonstockvaluetaxlimitonemployeestockpurchaseplan"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c42469-7123-4f87-ab3d-7cb3472b3ad9" xlink:to="loc_xers_Commonstockvaluetaxlimitonemployeestockpurchaseplan_308da090-ce17-41ea-a161-372744ecd8b9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent_61221edd-58f0-43c1-b440-8f662f41352e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c42469-7123-4f87-ab3d-7cb3472b3ad9" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent_61221edd-58f0-43c1-b440-8f662f41352e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Percentagesharesavailableforissuanceautomaticallyincreaseannually_69efc8ae-1814-4553-a8c4-d7f06ef7f924" xlink:href="xers-20201231.xsd#xers_Percentagesharesavailableforissuanceautomaticallyincreaseannually"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c42469-7123-4f87-ab3d-7cb3472b3ad9" xlink:to="loc_xers_Percentagesharesavailableforissuanceautomaticallyincreaseannually_69efc8ae-1814-4553-a8c4-d7f06ef7f924" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Leastamountofannualincreaseofsharesavailableforissuance_0d476174-8ef0-47ef-9950-5635ee674c44" xlink:href="xers-20201231.xsd#xers_Leastamountofannualincreaseofsharesavailableforissuance"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c42469-7123-4f87-ab3d-7cb3472b3ad9" xlink:to="loc_xers_Leastamountofannualincreaseofsharesavailableforissuance_0d476174-8ef0-47ef-9950-5635ee674c44" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized_9d9f28e9-05a6-4e30-b5b8-0ac321509242" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c42469-7123-4f87-ab3d-7cb3472b3ad9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized_9d9f28e9-05a6-4e30-b5b8-0ac321509242" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_29eb4338-b8bd-40bc-befc-6ab638eb34a6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c42469-7123-4f87-ab3d-7cb3472b3ad9" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_29eb4338-b8bd-40bc-befc-6ab638eb34a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOwnershipPlanESOPWeightedAveragePurchasePriceOfSharesPurchased_544e044b-2cca-476e-8118-f6e0bc978d31" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeStockOwnershipPlanESOPWeightedAveragePurchasePriceOfSharesPurchased"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c42469-7123-4f87-ab3d-7cb3472b3ad9" xlink:to="loc_us-gaap_EmployeeStockOwnershipPlanESOPWeightedAveragePurchasePriceOfSharesPurchased_544e044b-2cca-476e-8118-f6e0bc978d31" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_71f2dabe-c11e-4906-a35f-98545516239c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c42469-7123-4f87-ab3d-7cb3472b3ad9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_71f2dabe-c11e-4906-a35f-98545516239c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_150ed319-f9e2-4fab-bda5-d5819ed3a611" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c42469-7123-4f87-ab3d-7cb3472b3ad9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_150ed319-f9e2-4fab-bda5-d5819ed3a611" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_3af0835e-7b26-4edc-9f7b-d9bb29b2e5ba" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c42469-7123-4f87-ab3d-7cb3472b3ad9" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_3af0835e-7b26-4edc-9f7b-d9bb29b2e5ba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedWeightedAverageGrantDateFairValue_15a7d3b2-2025-4198-8700-080869285e4d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c42469-7123-4f87-ab3d-7cb3472b3ad9" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedWeightedAverageGrantDateFairValue_15a7d3b2-2025-4198-8700-080869285e4d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_f247e02d-20cf-4795-937c-d1e200660932" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c42469-7123-4f87-ab3d-7cb3472b3ad9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_f247e02d-20cf-4795-937c-d1e200660932" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestExercisableAggregateIntrinsicValue_8c34580b-e732-4aea-a4a9-35f1f252332c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestExercisableAggregateIntrinsicValue"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c42469-7123-4f87-ab3d-7cb3472b3ad9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestExercisableAggregateIntrinsicValue_8c34580b-e732-4aea-a4a9-35f1f252332c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_592e7014-f53f-4583-91b4-8f54b044c772" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c42469-7123-4f87-ab3d-7cb3472b3ad9" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_592e7014-f53f-4583-91b4-8f54b044c772" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_4113eeb2-efaa-425b-873d-cfb3a2c0c9a7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c42469-7123-4f87-ab3d-7cb3472b3ad9" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_4113eeb2-efaa-425b-873d-cfb3a2c0c9a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodUponOptionExchangeWeightedAverageExercisePrice_7d46f7c6-38a2-496b-a7d0-b2075d33689e" xlink:href="xers-20201231.xsd#xers_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodUponOptionExchangeWeightedAverageExercisePrice"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c42469-7123-4f87-ab3d-7cb3472b3ad9" xlink:to="loc_xers_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodUponOptionExchangeWeightedAverageExercisePrice_7d46f7c6-38a2-496b-a7d0-b2075d33689e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriodUponOptionExchange_62277c1f-f324-41b7-a885-8bc80bdb2fbb" xlink:href="xers-20201231.xsd#xers_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriodUponOptionExchange"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c42469-7123-4f87-ab3d-7cb3472b3ad9" xlink:to="loc_xers_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriodUponOptionExchange_62277c1f-f324-41b7-a885-8bc80bdb2fbb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsCancelledUponOptionExchange_cffd343d-e27a-45ba-b898-b7f5e6a0a526" xlink:href="xers-20201231.xsd#xers_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsCancelledUponOptionExchange"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c42469-7123-4f87-ab3d-7cb3472b3ad9" xlink:to="loc_xers_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsCancelledUponOptionExchange_cffd343d-e27a-45ba-b898-b7f5e6a0a526" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/StockCompensationPlanStockBasedCompensationExpenseDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#StockCompensationPlanStockBasedCompensationExpenseDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/StockCompensationPlanStockBasedCompensationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_be92b379-1747-4950-88cc-ae7e3e2576b9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_f9a90e8e-90c9-458e-96ac-3f0f72d7a8fe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_be92b379-1747-4950-88cc-ae7e3e2576b9" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_f9a90e8e-90c9-458e-96ac-3f0f72d7a8fe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_d0c6f041-5022-4942-9029-8c08aa56fd58" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_f9a90e8e-90c9-458e-96ac-3f0f72d7a8fe" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_d0c6f041-5022-4942-9029-8c08aa56fd58" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_13dad86e-b254-45ef-9b3e-ccaa2419adee" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_d0c6f041-5022-4942-9029-8c08aa56fd58" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_13dad86e-b254-45ef-9b3e-ccaa2419adee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_b62089e5-3890-4ab0-803a-e831c0ee2cf0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_13dad86e-b254-45ef-9b3e-ccaa2419adee" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_b62089e5-3890-4ab0-803a-e831c0ee2cf0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_5a63b618-f9df-4364-a4a5-c65a57211948" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_13dad86e-b254-45ef-9b3e-ccaa2419adee" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_5a63b618-f9df-4364-a4a5-c65a57211948" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfSalesMember_8ff31197-ee7e-4c19-aaa6-fc0eaf7d4abf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CostOfSalesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_13dad86e-b254-45ef-9b3e-ccaa2419adee" xlink:to="loc_us-gaap_CostOfSalesMember_8ff31197-ee7e-4c19-aaa6-fc0eaf7d4abf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_6730101e-d725-408b-a09f-7d087ebff781" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_f9a90e8e-90c9-458e-96ac-3f0f72d7a8fe" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_6730101e-d725-408b-a09f-7d087ebff781" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_af28fd39-3fc1-475a-aa29-ff9dff30362a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_6730101e-d725-408b-a09f-7d087ebff781" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_af28fd39-3fc1-475a-aa29-ff9dff30362a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/StockCompensationPlanRestrictedstockunitsactivityDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#StockCompensationPlanRestrictedstockunitsactivityDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/StockCompensationPlanRestrictedstockunitsactivityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_SharebasedPaymentArrangementRestrictedStockUnitsAbstract_88a9d313-688c-4043-9d22-a7391bb409d7" xlink:href="xers-20201231.xsd#xers_SharebasedPaymentArrangementRestrictedStockUnitsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_85044af6-f82c-4909-8ae3-e0342235db28" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_SharebasedPaymentArrangementRestrictedStockUnitsAbstract_88a9d313-688c-4043-9d22-a7391bb409d7" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_85044af6-f82c-4909-8ae3-e0342235db28" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_b8a982ea-89df-42ab-878f-0bcf8c1cb856" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_85044af6-f82c-4909-8ae3-e0342235db28" xlink:to="loc_us-gaap_AwardTypeAxis_b8a982ea-89df-42ab-878f-0bcf8c1cb856" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_26bcd0b3-5941-4142-876f-ce92519a1750" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_b8a982ea-89df-42ab-878f-0bcf8c1cb856" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_26bcd0b3-5941-4142-876f-ce92519a1750" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_1cb37153-118a-4161-b06e-62ee49ab11ea" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_26bcd0b3-5941-4142-876f-ce92519a1750" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_1cb37153-118a-4161-b06e-62ee49ab11ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3891b8ae-2559-4f3f-b331-fc0269af8b46" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_85044af6-f82c-4909-8ae3-e0342235db28" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3891b8ae-2559-4f3f-b331-fc0269af8b46" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_ba86d9e3-b7fe-4393-bf46-b070bfebdc4e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3891b8ae-2559-4f3f-b331-fc0269af8b46" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_ba86d9e3-b7fe-4393-bf46-b070bfebdc4e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_cc630e6d-543c-4d04-a40d-bbad9ddfdf23" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3891b8ae-2559-4f3f-b331-fc0269af8b46" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_cc630e6d-543c-4d04-a40d-bbad9ddfdf23" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_bf3d504e-c760-46e8-9b95-a806ad566e63" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3891b8ae-2559-4f3f-b331-fc0269af8b46" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_bf3d504e-c760-46e8-9b95-a806ad566e63" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_6d5ef294-d539-4423-a143-2a69c2ab2bce" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3891b8ae-2559-4f3f-b331-fc0269af8b46" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_6d5ef294-d539-4423-a143-2a69c2ab2bce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_51a992cc-63e2-4d39-8262-a71913e4bb94" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3891b8ae-2559-4f3f-b331-fc0269af8b46" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_51a992cc-63e2-4d39-8262-a71913e4bb94" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_5fadc913-7559-4dee-8ee9-9d6f389c873b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3891b8ae-2559-4f3f-b331-fc0269af8b46" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_5fadc913-7559-4dee-8ee9-9d6f389c873b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_0bb51514-1475-4dfa-8ee2-571016fb47de" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3891b8ae-2559-4f3f-b331-fc0269af8b46" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_0bb51514-1475-4dfa-8ee2-571016fb47de" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_1b58d79f-0de7-4494-bd2b-282ed54437ca" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3891b8ae-2559-4f3f-b331-fc0269af8b46" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_1b58d79f-0de7-4494-bd2b-282ed54437ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_2a98a723-63b5-4389-a695-d91afed01f1b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3891b8ae-2559-4f3f-b331-fc0269af8b46" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_2a98a723-63b5-4389-a695-d91afed01f1b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_5659a44f-3594-4577-ab2e-7be564043aba" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3891b8ae-2559-4f3f-b331-fc0269af8b46" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_5659a44f-3594-4577-ab2e-7be564043aba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_26233470-950b-406b-b2b2-91f2d99c4444" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3891b8ae-2559-4f3f-b331-fc0269af8b46" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_26233470-950b-406b-b2b2-91f2d99c4444" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_05bd18b8-8e7e-4c7c-9fbd-ca110916196f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3891b8ae-2559-4f3f-b331-fc0269af8b46" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_05bd18b8-8e7e-4c7c-9fbd-ca110916196f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_39022474-17c6-488f-82ad-498e9ac26f3f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3891b8ae-2559-4f3f-b331-fc0269af8b46" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_39022474-17c6-488f-82ad-498e9ac26f3f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_26911715-9b47-429f-86af-22f8fbc9e9e6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3891b8ae-2559-4f3f-b331-fc0269af8b46" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_26911715-9b47-429f-86af-22f8fbc9e9e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/FairValueMeasurement" xlink:type="simple" xlink:href="xers-20201231.xsd#FairValueMeasurement"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/FairValueMeasurement" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_5c1694cf-bf9f-47de-8f2a-d054991f17a0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresTextBlock_dbebab58-ca04-4354-9bb0-69ef4a27a4cf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueDisclosuresTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_5c1694cf-bf9f-47de-8f2a-d054991f17a0" xlink:to="loc_us-gaap_FairValueDisclosuresTextBlock_dbebab58-ca04-4354-9bb0-69ef4a27a4cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/FairValueMeasurementTables" xlink:type="simple" xlink:href="xers-20201231.xsd#FairValueMeasurementTables"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/FairValueMeasurementTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_024eebe7-19de-44e7-99db-ce3f7d372bc7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock_53292297-82f8-4f68-941b-d939739bae37" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_024eebe7-19de-44e7-99db-ce3f7d372bc7" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock_53292297-82f8-4f68-941b-d939739bae37" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTextBlock_bdbb2b20-414e-4773-96c8-a35d4f1e13ef" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_024eebe7-19de-44e7-99db-ce3f7d372bc7" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTextBlock_bdbb2b20-414e-4773-96c8-a35d4f1e13ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/FairValueMeasurementFairValueLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#FairValueMeasurementFairValueLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/FairValueMeasurementFairValueLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_dea7f23d-c771-455f-9bcf-0372eee796e5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_8edc7a9b-1b08-4a56-8b4a-dd743ef83c7d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_dea7f23d-c771-455f-9bcf-0372eee796e5" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_8edc7a9b-1b08-4a56-8b4a-dd743ef83c7d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeAxis_dcf09fed-396b-42f4-9e80-2162c7d0615d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InvestmentTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_8edc7a9b-1b08-4a56-8b4a-dd743ef83c7d" xlink:to="loc_us-gaap_InvestmentTypeAxis_dcf09fed-396b-42f4-9e80-2162c7d0615d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_b18a7e2a-1ada-44f8-b16d-4f844bf112f4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_dcf09fed-396b-42f4-9e80-2162c7d0615d" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_b18a7e2a-1ada-44f8-b16d-4f844bf112f4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasuryAndGovernmentMember_a7b8bbc2-5ac4-45d1-9d2f-3be836634d52" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_USTreasuryAndGovernmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_b18a7e2a-1ada-44f8-b16d-4f844bf112f4" xlink:to="loc_us-gaap_USTreasuryAndGovernmentMember_a7b8bbc2-5ac4-45d1-9d2f-3be836634d52" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_159b5b70-ccc2-4306-9c9f-ea829ff25654" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_b18a7e2a-1ada-44f8-b16d-4f844bf112f4" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_159b5b70-ccc2-4306-9c9f-ea829ff25654" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_7e2f8985-0426-4efa-990e-e7b518d507a2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommercialPaperMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_b18a7e2a-1ada-44f8-b16d-4f844bf112f4" xlink:to="loc_us-gaap_CommercialPaperMember_7e2f8985-0426-4efa-990e-e7b518d507a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_741a928e-b497-4327-baab-efef6270f8dd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_8edc7a9b-1b08-4a56-8b4a-dd743ef83c7d" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_741a928e-b497-4327-baab-efef6270f8dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_b3156a52-0c69-4149-83ae-7c5d48f15d84" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_741a928e-b497-4327-baab-efef6270f8dd" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_b3156a52-0c69-4149-83ae-7c5d48f15d84" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_1a2b46a0-cd16-4c41-8468-61d0d805fd5c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_b3156a52-0c69-4149-83ae-7c5d48f15d84" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_1a2b46a0-cd16-4c41-8468-61d0d805fd5c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_310cc01a-1072-4c78-8491-ae18faef55c9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_b3156a52-0c69-4149-83ae-7c5d48f15d84" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_310cc01a-1072-4c78-8491-ae18faef55c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_75729da9-16c9-4411-bb77-23390e0db852" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_b3156a52-0c69-4149-83ae-7c5d48f15d84" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_75729da9-16c9-4411-bb77-23390e0db852" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_2bab6990-a06e-459b-9f63-fe9ccbe6ab28" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_8edc7a9b-1b08-4a56-8b4a-dd743ef83c7d" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_2bab6990-a06e-459b-9f63-fe9ccbe6ab28" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsAtCarryingValue_09804577-e3bf-4c55-abec-95094f9cb537" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_MoneyMarketFundsAtCarryingValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_2bab6990-a06e-459b-9f63-fe9ccbe6ab28" xlink:to="loc_us-gaap_MoneyMarketFundsAtCarryingValue_09804577-e3bf-4c55-abec-95094f9cb537" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsFairValueDisclosure_c589e734-ef66-44b2-a386-b47cde7d5323" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InvestmentsFairValueDisclosure"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_2bab6990-a06e-459b-9f63-fe9ccbe6ab28" xlink:to="loc_us-gaap_InvestmentsFairValueDisclosure_c589e734-ef66-44b2-a386-b47cde7d5323" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding_3119a395-244e-4dd4-b19f-3adad477f0a8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_WarrantsAndRightsOutstanding"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_2bab6990-a06e-459b-9f63-fe9ccbe6ab28" xlink:to="loc_us-gaap_WarrantsAndRightsOutstanding_3119a395-244e-4dd4-b19f-3adad477f0a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_161dfe49-2dbb-4203-ac69-4bdcc379109d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueAdjustmentOfWarrants"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_2bab6990-a06e-459b-9f63-fe9ccbe6ab28" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_161dfe49-2dbb-4203-ac69-4bdcc379109d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/AvailableforSaleInvestmentsNotes" xlink:type="simple" xlink:href="xers-20201231.xsd#AvailableforSaleInvestmentsNotes"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/AvailableforSaleInvestmentsNotes" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_e0463d79-5e66-4a86-a134-010edc926e82" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsInDebtAndMarketableEquitySecuritiesAndCertainTradingAssetsDisclosureTextBlock_ba7084b3-4e55-41c1-aec7-57f143f6ac8d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InvestmentsInDebtAndMarketableEquitySecuritiesAndCertainTradingAssetsDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_e0463d79-5e66-4a86-a134-010edc926e82" xlink:to="loc_us-gaap_InvestmentsInDebtAndMarketableEquitySecuritiesAndCertainTradingAssetsDisclosureTextBlock_ba7084b3-4e55-41c1-aec7-57f143f6ac8d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/AvailableforSaleInvestmentsTables" xlink:type="simple" xlink:href="xers-20201231.xsd#AvailableforSaleInvestmentsTables"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/AvailableforSaleInvestmentsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_7464548c-6c4c-4f1a-8f56-4d7547a2220c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock_0d3c4a93-6e27-4af1-8044-74d533be5015" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_7464548c-6c4c-4f1a-8f56-4d7547a2220c" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock_0d3c4a93-6e27-4af1-8044-74d533be5015" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/AvailableforSaleInvestmentsDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#AvailableforSaleInvestmentsDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/AvailableforSaleInvestmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_90ede639-e1b3-462a-9a97-2974cdb8aac4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_8d54811d-708f-4ad1-9dce-63391eb9019e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_90ede639-e1b3-462a-9a97-2974cdb8aac4" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_8d54811d-708f-4ad1-9dce-63391eb9019e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeAxis_83c17b88-9d37-4e97-ac9e-4387edf0ae62" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InvestmentTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_8d54811d-708f-4ad1-9dce-63391eb9019e" xlink:to="loc_us-gaap_InvestmentTypeAxis_83c17b88-9d37-4e97-ac9e-4387edf0ae62" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_fe8a737f-76d7-4857-9f7d-78746ded082d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_83c17b88-9d37-4e97-ac9e-4387edf0ae62" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_fe8a737f-76d7-4857-9f7d-78746ded082d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_9d92b702-92c1-44eb-b6b1-9550a9b6e8b4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommercialPaperMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_fe8a737f-76d7-4857-9f7d-78746ded082d" xlink:to="loc_us-gaap_CommercialPaperMember_9d92b702-92c1-44eb-b6b1-9550a9b6e8b4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_25c91360-3a9d-4663-b933-0643bdea6e6f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_fe8a737f-76d7-4857-9f7d-78746ded082d" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_25c91360-3a9d-4663-b933-0643bdea6e6f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasuryAndGovernmentMember_88061162-b2c0-428a-9055-a608e6ebeb83" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_USTreasuryAndGovernmentMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_fe8a737f-76d7-4857-9f7d-78746ded082d" xlink:to="loc_us-gaap_USTreasuryAndGovernmentMember_88061162-b2c0-428a-9055-a608e6ebeb83" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_71a59c35-4915-4c28-bd63-581ffa22cf30" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_8d54811d-708f-4ad1-9dce-63391eb9019e" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_71a59c35-4915-4c28-bd63-581ffa22cf30" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_AvailableForSaleSecuritiesMaturitiesPeriod_53c6b078-6db4-4ef5-8198-a7a276f48c90" xlink:href="xers-20201231.xsd#xers_AvailableForSaleSecuritiesMaturitiesPeriod"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_71a59c35-4915-4c28-bd63-581ffa22cf30" xlink:to="loc_xers_AvailableForSaleSecuritiesMaturitiesPeriod_53c6b078-6db4-4ef5-8198-a7a276f48c90" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_20edb64f-308b-4661-9333-b7095028e3d8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAmortizedCost"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_71a59c35-4915-4c28-bd63-581ffa22cf30" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_20edb64f-308b-4661-9333-b7095028e3d8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_8e859cb2-fe46-45d8-a429-c74c2bc1cb76" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_71a59c35-4915-4c28-bd63-581ffa22cf30" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_8e859cb2-fe46-45d8-a429-c74c2bc1cb76" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_b2ad478e-3cf2-4388-b2e2-9bc63cecbb64" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_71a59c35-4915-4c28-bd63-581ffa22cf30" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_b2ad478e-3cf2-4388-b2e2-9bc63cecbb64" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsFairValueDisclosure_4094e643-65d8-46db-8d0a-42379204edf0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InvestmentsFairValueDisclosure"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_71a59c35-4915-4c28-bd63-581ffa22cf30" xlink:to="loc_us-gaap_InvestmentsFairValueDisclosure_4094e643-65d8-46db-8d0a-42379204edf0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/NetLossPerShareNotes" xlink:type="simple" xlink:href="xers-20201231.xsd#NetLossPerShareNotes"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/NetLossPerShareNotes" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_20c88340-2022-4b3e-9aa6-c4a620ed511c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareTextBlock_50e3cb1a-ee5d-4168-b3ed-c608aca0c86a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EarningsPerShareTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_20c88340-2022-4b3e-9aa6-c4a620ed511c" xlink:to="loc_us-gaap_EarningsPerShareTextBlock_50e3cb1a-ee5d-4168-b3ed-c608aca0c86a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/NetLossPerShareTables" xlink:type="simple" xlink:href="xers-20201231.xsd#NetLossPerShareTables"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/NetLossPerShareTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_AntidilutiveSecuritiesExcludedfromEarningsPerShareAbstract_369aaa02-59c7-4817-9926-47beb459a0d6" xlink:href="xers-20201231.xsd#xers_AntidilutiveSecuritiesExcludedfromEarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_24beefec-63b3-4993-aa22-759b567c1b17" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_AntidilutiveSecuritiesExcludedfromEarningsPerShareAbstract_369aaa02-59c7-4817-9926-47beb459a0d6" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_24beefec-63b3-4993-aa22-759b567c1b17" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_e765a1c0-31e9-4b16-b0a3-1ac2ef8f2151" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_24beefec-63b3-4993-aa22-759b567c1b17" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_e765a1c0-31e9-4b16-b0a3-1ac2ef8f2151" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_c8c04aaa-2720-459e-b009-21f32bd807ed" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_e765a1c0-31e9-4b16-b0a3-1ac2ef8f2151" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_c8c04aaa-2720-459e-b009-21f32bd807ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_fff6ed56-8c8e-45dc-aebc-d45aae7da8a8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_24beefec-63b3-4993-aa22-759b567c1b17" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_fff6ed56-8c8e-45dc-aebc-d45aae7da8a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_08933359-dceb-4a4f-9aac-638b98045fec" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_fff6ed56-8c8e-45dc-aebc-d45aae7da8a8" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_08933359-dceb-4a4f-9aac-638b98045fec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/NetLossPerShareDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#NetLossPerShareDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/NetLossPerShareDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.xerispharma.com/role/NetLossPerShareAntidilutiveSecuritiesExcludedfromComputationofEarningsPerShareDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#NetLossPerShareAntidilutiveSecuritiesExcludedfromComputationofEarningsPerShareDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/NetLossPerShareAntidilutiveSecuritiesExcludedfromComputationofEarningsPerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_AntidilutiveSecuritiesExcludedfromEarningsPerShareAbstract_7963c8f4-d8df-472f-9064-537597e6f7e4" xlink:href="xers-20201231.xsd#xers_AntidilutiveSecuritiesExcludedfromEarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_ffb57bc9-a396-451a-96f1-141056a0a6cb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_AntidilutiveSecuritiesExcludedfromEarningsPerShareAbstract_7963c8f4-d8df-472f-9064-537597e6f7e4" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_ffb57bc9-a396-451a-96f1-141056a0a6cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_17438246-a1a2-4daa-a15e-8baaa6aafd62" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_ffb57bc9-a396-451a-96f1-141056a0a6cb" xlink:to="loc_us-gaap_StatementClassOfStockAxis_17438246-a1a2-4daa-a15e-8baaa6aafd62" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_c4ad7694-0954-470e-9ea4-cb15f6470d18" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_17438246-a1a2-4daa-a15e-8baaa6aafd62" xlink:to="loc_us-gaap_ClassOfStockDomain_c4ad7694-0954-470e-9ea4-cb15f6470d18" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtSecuritiesMember_f94ab7a4-4772-461b-89b7-8f5cb95f292c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConvertibleDebtSecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_c4ad7694-0954-470e-9ea4-cb15f6470d18" xlink:to="loc_us-gaap_ConvertibleDebtSecuritiesMember_f94ab7a4-4772-461b-89b7-8f5cb95f292c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockOptionMember_03cfe67f-c194-4a71-bc95-3bc981202345" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockOptionMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_c4ad7694-0954-470e-9ea4-cb15f6470d18" xlink:to="loc_us-gaap_StockOptionMember_03cfe67f-c194-4a71-bc95-3bc981202345" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_44f42c5c-c7b1-43d2-9309-57830c465b93" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_c4ad7694-0954-470e-9ea4-cb15f6470d18" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_44f42c5c-c7b1-43d2-9309-57830c465b93" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_367ebc54-843d-4c0f-b994-65e40136559f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_WarrantMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_c4ad7694-0954-470e-9ea4-cb15f6470d18" xlink:to="loc_us-gaap_WarrantMember_367ebc54-843d-4c0f-b994-65e40136559f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_49b40c3b-eeb0-48f0-85cc-9a75824e9dd2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_ffb57bc9-a396-451a-96f1-141056a0a6cb" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_49b40c3b-eeb0-48f0-85cc-9a75824e9dd2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_1938da82-6635-4e70-9adc-d2153f6345bc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_49b40c3b-eeb0-48f0-85cc-9a75824e9dd2" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_1938da82-6635-4e70-9adc-d2153f6345bc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_7350b999-cf1c-4efc-8157-8abacb7c5978" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_ffb57bc9-a396-451a-96f1-141056a0a6cb" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_7350b999-cf1c-4efc-8157-8abacb7c5978" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_87541254-66dd-42c9-8315-2f5df3d08121" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_7350b999-cf1c-4efc-8157-8abacb7c5978" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_87541254-66dd-42c9-8315-2f5df3d08121" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/OtherEmployeeBenefitPlansNotes" xlink:type="simple" xlink:href="xers-20201231.xsd#OtherEmployeeBenefitPlansNotes"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/OtherEmployeeBenefitPlansNotes" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PostemploymentBenefitsAbstract_0a142caf-2ad5-4c32-8076-b536fe7727c0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PostemploymentBenefitsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CompensationAndEmployeeBenefitPlansTextBlock_d7ff76ad-c971-4aa1-8ba1-d90856135639" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CompensationAndEmployeeBenefitPlansTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PostemploymentBenefitsAbstract_0a142caf-2ad5-4c32-8076-b536fe7727c0" xlink:to="loc_us-gaap_CompensationAndEmployeeBenefitPlansTextBlock_d7ff76ad-c971-4aa1-8ba1-d90856135639" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/OtherEmployeeBenefitPlansDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#OtherEmployeeBenefitPlansDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/OtherEmployeeBenefitPlansDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CompensationAndRetirementDisclosureAbstract_91437dce-8984-4e19-977e-894c5e5c09c0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CompensationAndRetirementDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedContributionPlanEmployerDiscretionaryContributionAmount_5d353cf5-d26a-4be4-9903-7450cd5c9b27" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DefinedContributionPlanEmployerDiscretionaryContributionAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CompensationAndRetirementDisclosureAbstract_91437dce-8984-4e19-977e-894c5e5c09c0" xlink:to="loc_us-gaap_DefinedContributionPlanEmployerDiscretionaryContributionAmount_5d353cf5-d26a-4be4-9903-7450cd5c9b27" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredCompensationArrangementWithIndividualCompensationExpense_590a6030-5ad6-4528-870b-1346ab79a0c9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredCompensationArrangementWithIndividualCompensationExpense"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CompensationAndRetirementDisclosureAbstract_91437dce-8984-4e19-977e-894c5e5c09c0" xlink:to="loc_us-gaap_DeferredCompensationArrangementWithIndividualCompensationExpense_590a6030-5ad6-4528-870b-1346ab79a0c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredCompensationArrangementWithIndividualCashAwardsGrantedPercentage_fbf140f5-a469-4ae3-9423-2cd6ea86f9b3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredCompensationArrangementWithIndividualCashAwardsGrantedPercentage"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CompensationAndRetirementDisclosureAbstract_91437dce-8984-4e19-977e-894c5e5c09c0" xlink:to="loc_us-gaap_DeferredCompensationArrangementWithIndividualCashAwardsGrantedPercentage_fbf140f5-a469-4ae3-9423-2cd6ea86f9b3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_DeferredCompensationAccruedInterestRate_28faca97-e832-4d51-bcc5-cb1999f5e1f4" xlink:href="xers-20201231.xsd#xers_DeferredCompensationAccruedInterestRate"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CompensationAndRetirementDisclosureAbstract_91437dce-8984-4e19-977e-894c5e5c09c0" xlink:to="loc_xers_DeferredCompensationAccruedInterestRate_28faca97-e832-4d51-bcc5-cb1999f5e1f4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/IncomeTaxesNotes" xlink:type="simple" xlink:href="xers-20201231.xsd#IncomeTaxesNotes"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/IncomeTaxesNotes" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_e98762ff-3ca9-4532-9528-66a87cf034d9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureTextBlock_09fe8b57-7148-455b-8d05-7d84779a6c1e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_e98762ff-3ca9-4532-9528-66a87cf034d9" xlink:to="loc_us-gaap_IncomeTaxDisclosureTextBlock_09fe8b57-7148-455b-8d05-7d84779a6c1e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/IncomeTaxesTables" xlink:type="simple" xlink:href="xers-20201231.xsd#IncomeTaxesTables"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/IncomeTaxesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_52d77a5d-c656-40e8-9db9-04af8dbb1e89" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock_ee5f9581-e28c-4fbd-8398-bcdbd3384163" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_52d77a5d-c656-40e8-9db9-04af8dbb1e89" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock_ee5f9581-e28c-4fbd-8398-bcdbd3384163" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SummaryOfValuationAllowanceTextBlock_2eda7f37-6602-43b4-8ef6-52c44d6bad71" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SummaryOfValuationAllowanceTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_52d77a5d-c656-40e8-9db9-04af8dbb1e89" xlink:to="loc_us-gaap_SummaryOfValuationAllowanceTextBlock_2eda7f37-6602-43b4-8ef6-52c44d6bad71" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock_fe21923d-aff9-4cd9-bd2a-9b37273d41f7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_52d77a5d-c656-40e8-9db9-04af8dbb1e89" xlink:to="loc_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock_fe21923d-aff9-4cd9-bd2a-9b37273d41f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock_f65bd422-717a-4165-aa28-9936b549a463" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_52d77a5d-c656-40e8-9db9-04af8dbb1e89" xlink:to="loc_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock_f65bd422-717a-4165-aa28-9936b549a463" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SummaryOfPositionsForWhichSignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleTextBlock_956c5296-7194-43d9-9cef-b1fc50a521e9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SummaryOfPositionsForWhichSignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleTextBlock"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_52d77a5d-c656-40e8-9db9-04af8dbb1e89" xlink:to="loc_us-gaap_SummaryOfPositionsForWhichSignificantChangeInUnrecognizedTaxBenefitsIsReasonablyPossibleTextBlock_956c5296-7194-43d9-9cef-b1fc50a521e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.xerispharma.com/role/IncomeTaxesDetails" xlink:type="simple" xlink:href="xers-20201231.xsd#IncomeTaxesDetails"/>
  <link:presentationLink xlink:role="http://www.xerispharma.com/role/IncomeTaxesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_xers_IncomeTaxesAbstract_91dc949a-d115-4fb0-b0bc-40106b462ec7" xlink:href="xers-20201231.xsd#xers_IncomeTaxesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowanceTable_d039a543-e634-4311-a1d9-d1e9e9aa60de" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ValuationAllowanceTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_IncomeTaxesAbstract_91dc949a-d115-4fb0-b0bc-40106b462ec7" xlink:to="loc_us-gaap_ValuationAllowanceTable_d039a543-e634-4311-a1d9-d1e9e9aa60de" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowanceByDeferredTaxAssetAxis_d4839a4e-89a4-42e0-ae51-ed32138fd8b0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ValuationAllowanceByDeferredTaxAssetAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceTable_d039a543-e634-4311-a1d9-d1e9e9aa60de" xlink:to="loc_us-gaap_ValuationAllowanceByDeferredTaxAssetAxis_d4839a4e-89a4-42e0-ae51-ed32138fd8b0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetDomain_9d2cf387-5ea9-4246-8bcc-79038bcee079" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceByDeferredTaxAssetAxis_d4839a4e-89a4-42e0-ae51-ed32138fd8b0" xlink:to="loc_us-gaap_DeferredTaxAssetDomain_9d2cf387-5ea9-4246-8bcc-79038bcee079" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ValuationAllowanceLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceTable_d039a543-e634-4311-a1d9-d1e9e9aa60de" xlink:to="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwards_e2d06521-0152-47ef-ad94-fd84092b04d4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLossCarryforwards"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:to="loc_us-gaap_OperatingLossCarryforwards_e2d06521-0152-47ef-ad94-fd84092b04d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationDeductions_1d31e18a-9f0f-415a-9db1-5b6ef3b2344f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationDeductions"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationDeductions_1d31e18a-9f0f-415a-9db1-5b6ef3b2344f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Federalresearchincometaxcreditsgrossofvaluationallowance_ddfd93e2-ee3e-4137-9a7b-6628df7fcdfa" xlink:href="xers-20201231.xsd#xers_Federalresearchincometaxcreditsgrossofvaluationallowance"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:to="loc_xers_Federalresearchincometaxcreditsgrossofvaluationallowance_ddfd93e2-ee3e-4137-9a7b-6628df7fcdfa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Stateresearchincometaxcreditsgrossofvaluationallowance_76de0c6b-adeb-4e61-9aa8-94a92f3bff38" xlink:href="xers-20201231.xsd#xers_Stateresearchincometaxcreditsgrossofvaluationallowance"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:to="loc_xers_Stateresearchincometaxcreditsgrossofvaluationallowance_76de0c6b-adeb-4e61-9aa8-94a92f3bff38" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_Operatinglosscarryforwardsvariousstates_846c13de-efd8-459a-89ea-f720f2bbeed3" xlink:href="xers-20201231.xsd#xers_Operatinglosscarryforwardsvariousstates"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:to="loc_xers_Operatinglosscarryforwardsvariousstates_846c13de-efd8-459a-89ea-f720f2bbeed3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_357164c3-6d0e-486c-bcf4-7eb6867c164e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:to="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_357164c3-6d0e-486c-bcf4-7eb6867c164e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_37a88005-1aec-48d0-a118-d3ed7b934fb5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:to="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_37a88005-1aec-48d0-a118-d3ed7b934fb5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecognizedTaxBenefits_14361734-c45f-496e-806a-99759797a810" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_UnrecognizedTaxBenefits"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:to="loc_us-gaap_UnrecognizedTaxBenefits_14361734-c45f-496e-806a-99759797a810" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_df080ee5-d281-4c52-b8c2-160db6791265" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_df080ee5-d281-4c52-b8c2-160db6791265" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsPeriodIncreaseDecrease_087e51d6-bf9e-48e8-867f-fa0742ebf301" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsPeriodIncreaseDecrease"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsPeriodIncreaseDecrease_087e51d6-bf9e-48e8-867f-fa0742ebf301" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions_4d287b34-86f4-4328-94da-f68c6e3ecfa7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions_4d287b34-86f4-4328-94da-f68c6e3ecfa7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_3d71f039-283d-4e29-9006-152848277bff" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwards"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_3d71f039-283d-4e29-9006-152848277bff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch_57be9e2d-ca74-4fe5-bb3f-44be43861271" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch_57be9e2d-ca74-4fe5-bb3f-44be43861271" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_29c89a5c-1644-4fa1-aac6-a6fe4d2a0bd3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_29c89a5c-1644-4fa1-aac6-a6fe4d2a0bd3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOther_cb44d57e-804c-4e8d-83ff-c2526c295768" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsOther"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:to="loc_us-gaap_DeferredTaxAssetsOther_cb44d57e-804c-4e8d-83ff-c2526c295768" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_b316d067-6496-455e-b61e-1e0e6690b08d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsValuationAllowance"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_b316d067-6496-455e-b61e-1e0e6690b08d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_444d9c85-bb3f-47cf-9928-76e4b5530132" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:to="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_444d9c85-bb3f-47cf-9928-76e4b5530132" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_039ce160-1df7-4d2f-a379-3a290f4c7e2c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_039ce160-1df7-4d2f-a379-3a290f4c7e2c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_xers_DeferredTaxLiabilitiesFixedandIntangibleAssets_0cb39732-be93-4c87-89f2-b222c380853a" xlink:href="xers-20201231.xsd#xers_DeferredTaxLiabilitiesFixedandIntangibleAssets"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:to="loc_xers_DeferredTaxLiabilitiesFixedandIntangibleAssets_0cb39732-be93-4c87-89f2-b222c380853a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesOther_2e34bd34-e259-45af-be84-e76f31f9a7f5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxLiabilitiesOther"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesOther_2e34bd34-e259-45af-be84-e76f31f9a7f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_488a8a1e-a4e1-47ac-935f-667da99bcf2e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilities_488a8a1e-a4e1-47ac-935f-667da99bcf2e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_90709f80-3ac9-4a14-bc35-f9f5219e7911" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNet"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:to="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_90709f80-3ac9-4a14-bc35-f9f5219e7911" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_3ab164c8-0ebb-47bc-92dd-5bed8dbd4360" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:to="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_3ab164c8-0ebb-47bc-92dd-5bed8dbd4360" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_6f32b301-5e18-4ca7-8de8-3bf64c2856c1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_6f32b301-5e18-4ca7-8de8-3bf64c2856c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExaminationPenaltiesAndInterestExpense_39b8c92e-ab07-4c3a-a073-ca3bc51ff06e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxExaminationPenaltiesAndInterestExpense"/>
    <link:presentationArc order="25" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowanceLineItems_15d67e58-8fa2-419b-b188-404ba5563f89" xlink:to="loc_us-gaap_IncomeTaxExaminationPenaltiesAndInterestExpense_39b8c92e-ab07-4c3a-a073-ca3bc51ff06e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxCreditsResearch_4ab5b0b1-35cb-4dab-8333-fd07c3ff941c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxReconciliationTaxCreditsResearch"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_IncomeTaxesAbstract_91dc949a-d115-4fb0-b0bc-40106b462ec7" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxCreditsResearch_4ab5b0b1-35cb-4dab-8333-fd07c3ff941c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromCurrentPeriodTaxPositions_1781687f-fd65-416f-a242-c5446e4368d9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromCurrentPeriodTaxPositions"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_IncomeTaxesAbstract_91dc949a-d115-4fb0-b0bc-40106b462ec7" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromCurrentPeriodTaxPositions_1781687f-fd65-416f-a242-c5446e4368d9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_76858fc5-2ea2-4aab-bf92-4a269523e19c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxReconciliationOtherAdjustments"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_IncomeTaxesAbstract_91dc949a-d115-4fb0-b0bc-40106b462ec7" xlink:to="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_76858fc5-2ea2-4aab-bf92-4a269523e19c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationShareBasedCompensationExcessTaxBenefitAmount_bb8528eb-fd6b-4df8-a879-6fdccd3daa28" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationShareBasedCompensationExcessTaxBenefitAmount"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_IncomeTaxesAbstract_91dc949a-d115-4fb0-b0bc-40106b462ec7" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationShareBasedCompensationExcessTaxBenefitAmount_bb8528eb-fd6b-4df8-a879-6fdccd3daa28" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationPriorYearIncomeTaxes_ef17b199-98c3-453d-a84f-d832b58e40dd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxReconciliationPriorYearIncomeTaxes"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_IncomeTaxesAbstract_91dc949a-d115-4fb0-b0bc-40106b462ec7" xlink:to="loc_us-gaap_IncomeTaxReconciliationPriorYearIncomeTaxes_ef17b199-98c3-453d-a84f-d832b58e40dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationOtherReconcilingItems_78193430-6fd6-47ef-bc19-51c310b80b05" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxReconciliationOtherReconcilingItems"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_xers_IncomeTaxesAbstract_91dc949a-d115-4fb0-b0bc-40106b462ec7" xlink:to="loc_us-gaap_IncomeTaxReconciliationOtherReconcilingItems_78193430-6fd6-47ef-bc19-51c310b80b05" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
